| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.060 | GeneticVariation | BEFREE | To investigate whether ambient agricultural OP exposure and PON1 L55M influence the rate of motor, cognitive, and mood-related symptom progression in PD. | 28689109 | 2017 |
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|
0.060 | GeneticVariation | BEFREE | In Parkinson's disease most of the studies suggest no participation of either L55M or the Q192R polymorphisms in its pathogenesis. | 24225313 | 2014 |
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|
0.060 | GeneticVariation | BEFREE | The polymorphism Leu54Met (rs854560) in PON1, impairing enzyme activity and leading to decreased PON1 expression levels, has been reported to be associated with Parkinson's disease (PD). | 22704918 | 2012 |
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|
0.060 | GeneticVariation | BEFREE | Case-control studies of PON1 genetic variants in Alzheimer's disease (AD) and Parkinson's disease (PD) have revealed some positive albeit inconsistent associations with 2 PON1 coding polymorphisms: Q192R (rs662) and L55M (rs854560). | 20947215 | 2012 |
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|
0.060 | GeneticVariation | BEFREE | Paraoxonase 1 polymorphisms L55M and Q192R were not risk factors for Parkinson's disease: a HuGE review and meta-analysis. | 22521594 | 2012 |
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|
0.060 | GeneticVariation | BEFREE | Our results suggest that the M54L and Q192R polymorphisms are not major risk factors for PD in the Finnish population. | 15331145 | 2004 |
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|
0.030 | GeneticVariation | BEFREE | Case-control studies of PON1 genetic variants in Alzheimer's disease (AD) and Parkinson's disease (PD) have revealed some positive albeit inconsistent associations with 2 PON1 coding polymorphisms: Q192R (rs662) and L55M (rs854560). | 20947215 | 2012 |
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|
0.030 | GeneticVariation | BEFREE | Paraoxonase 1 polymorphisms L55M and Q192R were not risk factors for Parkinson's disease: a HuGE review and meta-analysis. | 22521594 | 2012 |
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|
0.030 | GeneticVariation | BEFREE | Our results suggest that the M54L and Q192R polymorphisms are not major risk factors for PD in the Finnish population. | 15331145 | 2004 |