Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE BDNF (rs6265) and CRY1 (rs2287161) variants have been associated with more depressive symptoms in people with PD. 31292011

2020

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Pattern of cortical thinning associated with the BDNF Val66Met polymorphism in Parkinson's disease. 31202861

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cognitive impairment in PD, especially in Caucasian populations. 31365694

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The objective was to investigate if high cadence cycling altered non-motor cognition and depression symptoms in individuals with Parkinson's disease (PD) and whether exercise responses were influenced by brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. 31197095

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Our meta-analysis implicates Val66Met BDNF polymorphism may be associated with Parkinson's disease cognitive impairment, further well-designed studies with larger populations are required to validate these results owing to the limited research. 31104169

2019

dbSNP: rs746682028
rs746682028
0.100 GeneticVariation BEFREE Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cognitive impairment in PD, especially in Caucasian populations. 31365694

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cognitive impairment in PD, especially in Caucasian populations. 31365694

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Our meta-analysis implicates Val66Met BDNF polymorphism may be associated with Parkinson's disease cognitive impairment, further well-designed studies with larger populations are required to validate these results owing to the limited research. 31104169

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Pattern of cortical thinning associated with the BDNF Val66Met polymorphism in Parkinson's disease. 31202861

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The objective was to investigate if high cadence cycling altered non-motor cognition and depression symptoms in individuals with Parkinson's disease (PD) and whether exercise responses were influenced by brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. 31197095

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE A total of 27 individuals (age = 65.4 ± 8.1 years; males = 14, females = 13) with neurologist-diagnosed PD with 13 genotyped for BDNF as Val66Val, 11 as Val66Met, 2 as Met66Met (1 refused). 29547479

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE To determine whether dopaminergic (rs1076560 DRD2 G > T and rs4680 catechole-o-methyltranspherase (COMT) Val158Met) or brain derived neurotrophic factor (rs6265 BDNF Val66Met) genetic polymorphisms are associated with gait function and medication responsiveness in Parkinson's disease. 29249680

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Here we review the role and relevance of the BDNF Val66Met polymorphism in neurodegenerative diseases, with particular emphasis on glaucoma, multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD). 29896439

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE We examined if the single nucleotide variant rs6265 in the gene Bdnf alters clinical phenotype in early-stage, unmedicated PD. 29759928

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Here we review the role and relevance of the BDNF Val66Met polymorphism in neurodegenerative diseases, with particular emphasis on glaucoma, multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD). 29896439

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE To determine whether dopaminergic (rs1076560 DRD2 G > T and rs4680 catechole-o-methyltranspherase (COMT) Val158Met) or brain derived neurotrophic factor (rs6265 BDNF Val66Met) genetic polymorphisms are associated with gait function and medication responsiveness in Parkinson's disease. 29249680

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE A total of 27 individuals (age = 65.4 ± 8.1 years; males = 14, females = 13) with neurologist-diagnosed PD with 13 genotyped for BDNF as Val66Val, 11 as Val66Met, 2 as Met66Met (1 refused). 29547479

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms. 27852165

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms. 27852165

2017

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE These results suggest a role for BDNF Val66Met polymorphism on cognitive impairment in PD. 26806863

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE These results suggest a role for BDNF Val66Met polymorphism on cognitive impairment in PD. 26806863

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Our data do not support a major role for the BDNF Val66Met polymorphism in the pathogenesis of PD. 25431370

2015

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The Val66Met polymorphism of BDNF (rs6265) has been associated with functional differences (mainly cognitive) between healthy adults and also with differences in the clinical expression of several other neuropsychiatric illnesses including PD. 25444596

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The Val66Met polymorphism of BDNF (rs6265) has been associated with functional differences (mainly cognitive) between healthy adults and also with differences in the clinical expression of several other neuropsychiatric illnesses including PD. 25444596

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Our data do not support a major role for the BDNF Val66Met polymorphism in the pathogenesis of PD. 25431370

2015