Gene: CARD14 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11652075
rs11652075
SGSH ; CARD14
0.840 GeneticVariation BEFREE Our results demonstrate a significant association between the CARD14 rs11652075 polymorphism and psoriasis. 27706581

2016
dbSNP: rs11652075
rs11652075
SGSH ; CARD14
0.840 GeneticVariation BEFREE The common CARD14 p.Arg820Trp variant might have a significant effect on the response to anti-TNF therapies among patients with psoriasis. 26854129

2016
dbSNP: rs11652075
rs11652075
SGSH ; CARD14
0.840 GeneticVariation BEFREE We confirmed the association between SNP rs11652075 at the CARD14 gene and Psor. 23905699

2013
dbSNP: rs11652075
rs11652075
SGSH ; CARD14
0.840 GeneticVariation GWASDB Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. 23143594

2012
dbSNP: rs11652075
rs11652075
SGSH ; CARD14
C 0.840 GeneticVariation GWASCAT Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. 23143594

2012
dbSNP: rs11652075
rs11652075
SGSH ; CARD14
0.840 GeneticVariation BEFREE Over 20 CARD14 polymorphisms were also genotyped, and meta-analysis revealed an association between psoriasis and rs11652075 (c.2458C>T [p.Arg820Trp]; p value = 2.1 × 10(-6)). 22521419

2012
dbSNP: rs281875215
rs281875215
CARD14
0.030 GeneticVariation BEFREE Rare, highly penetrant, gain-of-function, dominantly acting mutations within the human caspase recruitment domain family, member 14 (CARD14) gene lead to the development of PS and psoriatic arthritis (PSA) (a familial p.G117S and de-novo p.E138A alteration). 31323190

2019
dbSNP: rs281875215
rs281875215
CARD14
0.030 GeneticVariation BEFREE In contrast with wild-type CARD14, CARD14(E138A) and CARD14(G117S) psoriasis mutants interacted constitutively with BCL10 and MALT1, and triggered BCL10- and MALT1-dependent activation of NF-κB in keratinocytes. 27071417

2016
dbSNP: rs281875215
rs281875215
CARD14
0.030 GeneticVariation BEFREE One family exhibiting suggestive evidence for linkage to 17q25 (PSORS2) was identified and all affected members harboured a p.Gly117Ser mutation in CARD14 (caspase recruitment domain family, member 14), recently reported to lead to psoriasis in a large family from the U.S.A. 23013406

2013
dbSNP: rs281875214
rs281875214
CARD14
0.020 GeneticVariation BEFREE Rare, highly penetrant, gain-of-function, dominantly acting mutations within the human caspase recruitment domain family, member 14 (CARD14) gene lead to the development of PS and psoriatic arthritis (PSA) (a familial p.G117S and de-novo p.E138A alteration). 31323190

2019
dbSNP: rs281875214
rs281875214
CARD14
0.020 GeneticVariation BEFREE Inhibition of MALT1 with mepazine reduced CARD14(E138A)-induced expression of specific psoriasis-associated transcripts in keratinocytes. 27071417

2016