|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although there are some limitations on the study, our results indicate there is a lack of association between the Val66Met polymorphism and either of the two psychoses.
|
17417060 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The findings suggest that the COMT(Val158Met) polymorphism moderates affective and psychotic responses to stress in patients with psychosis, providing evidence for gene-environment interaction mechanisms in the formation of psychotic symptoms.
|
17525974 |
2008 |
|
rs6313
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Subjects with possible or probable AD or mild cognitive impairment (MCI) without psychosis at study entry were genotyped for the HTR2A T102C polymorphism and reassessed every 6 months until psychosis onset.
|
17525976 |
2007 |
|
rs2619538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DTNBP1 showed significant associations with methamphetamine psychosis at polymorphisms of P1635 (rs3213207, p = .00003) and SNPA (rs2619538, p = .049) and the three-locus haplotype of P1655 (rs2619539)-P1635-SNPA (permutation p = .0005).
|
17555717 |
2008 |
|
rs2619539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DTNBP1 showed significant associations with methamphetamine psychosis at polymorphisms of P1635 (rs3213207, p = .00003) and SNPA (rs2619538, p = .049) and the three-locus haplotype of P1655 (rs2619539)-P1635-SNPA (permutation p = .0005).
|
17555717 |
2008 |
|
rs3213207
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DTNBP1 showed significant associations with methamphetamine psychosis at polymorphisms of P1635 (rs3213207, p = .00003) and SNPA (rs2619538, p = .049) and the three-locus haplotype of P1655 (rs2619539)-P1635-SNPA (permutation p = .0005).
|
17555717 |
2008 |
|
rs2076369
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of these SNPs, rs713729 was significantly associated with methamphetamine abusers in general, and rs713729 and rs2076369 were significantly associated with those with spontaneous relapse of psychosis.
|
17606663 |
2007 |
|
rs713729
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of these SNPs, rs713729 was significantly associated with methamphetamine abusers in general, and rs713729 and rs2076369 were significantly associated with those with spontaneous relapse of psychosis.
|
17606663 |
2007 |
|
rs6313
|
|
|
0.070 |
GeneticVariation |
BEFREE |
No significant differences in the distribution of allele and genotype frequencies of the 5-HTTLPR (p>0.01) and 5-HT2A T102C (p>0.05) were found between patients and controls as well as between the patients' subgroups without and with psychosis.
|
17614196 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, carriers of the COMT Val(158)Met Val allele were more susceptible to the effect of stress on the psychosis outcome than those with the Met/Met genotype (test for interaction: chi2 = 5.02, df = 1, p = 0.025).
|
17640440 |
2007 |
|
rs1655285
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk haplotype for psychotic disorder also associated to perseverations (P = 0.035; for rs751229 alone P = 0.0012), and a protective haplotype G-T-G with rs1655285 in addition to auditory attention (P = 0.0059).
|
17673452 |
2007 |
|
rs3738401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Consistent with an earlier finding in Finnish SCZ families, the haplotype T-A of rs751229 and rs3738401 at the 5' end of DISC1 was over-transmitted to males with psychotic disorder (P = 0.008; for an extended haplotype P = 0.0007 with both genders).
|
17673452 |
2007 |
|
rs751229
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk haplotype for psychotic disorder also associated to perseverations (P = 0.035; for rs751229 alone P = 0.0012), and a protective haplotype G-T-G with rs1655285 in addition to auditory attention (P = 0.0059).
|
17673452 |
2007 |
|
rs6313
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Most replicated data suggest C allele of the 102 T/C and Tyr452 variants as risk factor for psychosis and antipsychotic response, but the number of not replicating studies does not allow to draw any definite conclusion.
|
17691947 |
2007 |
|
rs3745274
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.
|
17968817 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of the study was to evaluate the influence of COMT Val158Met polymorphism genotype in the phenotypic expression of first episode psychosis at onset.
|
18092319 |
2008 |
|
rs6994992
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The neuregulin 1 (NRG1) promoter single nucleotide polymorphism (SNP) rs6994992 has shown association with decreased activation of frontal and temporal lobe regions, increased risk of psychosis, and decreased premorbid IQ.
|
18286587 |
2008 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were analyzed in a sample of 84 adolescent Caucasian patients with first-episode psychosis (ages 11-17) and 85 healthy Caucasian controls (ages 10-17).
|
18351593 |
2008 |
|
rs6280
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were analyzed in a sample of 84 adolescent Caucasian patients with first-episode psychosis (ages 11-17) and 85 healthy Caucasian controls (ages 10-17).
|
18351593 |
2008 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, using an epidemiologically-based sample of 130 patients experiencing a first-episode of a non-affective psychosis, we examined whether COMT Val158Met genotype influenced cognitive performance on the phenotypic expression of psychosis.
|
18407467 |
2008 |
|
rs6994992
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) increases the risk of psychosis, affects prefrontal activation and structural connectivity in the brain, and is related to the expression of a specific neuregulin 1 isoform.
|
18543275 |
2009 |
|
rs135745
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was also no significant association between rs135745 and the clinical characteristics of methamphetamine dependence and co-morbid methamphetamine psychosis (e.g., age of first consumption, latency of psychosis, prognosis of psychosis after therapy, spontaneous relapse of psychotic symptoms, and poly-substance abuse status).
|
18991847 |
2008 |
|
rs6280
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In this first phase of the project, the objective was to investigate the distribution of four candidate genetic polymorphisms for functional psychosis (Ser9Gly DRD3, 5HTTLPR, the VNTR 3'-UTR SLC6A3 and Val66Met BDNF) in a case-control sample.
|
19142409 |
2008 |
|
rs3800373
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After analyzing the FKBP5 gene for single nucleotide polymorphisms, we found that rs3800373 CC genotype is more frequent in the MDD and MDD/Psychosis groups.
|
19199039 |
2009 |
|
rs1421292
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two haplotypes G-A of M12 (rs3916965)-M15 (rs2391191) (p=0.00024) and T-T of M23 (rs947267)-M24 (rs1421292) (p=0.00085) also showed associations with methamphetamine psychosis.
|
19482054 |
2009 |