|
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Sign of these predictive effects is opposite: subjects with MTHFR 677C>T polymorphism have lower likelihood of renal insufficiency; differently, wild-type MTHFR genotype subjects have lower GFR and greater hsCRP, iPTH, RRI, and LVH.
|
23534584 |
2013 |
|
rs4961
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism (Gly460Trp) within the alpha-adducin gene (ADD1) may influence several renal phenotypes, including salt sensitivity, susceptibility to renal failure, the renal haemodynamics and confer a worse cardiovascular risks profile.
|
16612256 |
2006 |
|
rs151340626
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CLCN5 mutation Ser244Leu is associated with X-linked renal failure without X-linked recessive hypophosphatemic rickets.
|
9452997 |
1998 |
|
rs11739136
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Common KCNMB1 gain-of-function variant Glu65Lys influences GFR, and 65Lys carriers exhibit not only elevated baseline GFR, but also more rapid GFR decline (and consequent development of renal failure) in CKD.
|
20861615 |
2010 |
|
rs4821480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Contrasting the 751 T2DM-ESRD cases with 227 T2DM non-nephropathy controls revealed that E1 haplotype SNPs rs4821480, rs2032487 and rs4821481 were associated with kidney failure (OR 1.38-1.40 recessive, all P < 0.048).
|
19567477 |
2009 |
|
rs2032487
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Contrasting the 751 T2DM-ESRD cases with 227 T2DM non-nephropathy controls revealed that E1 haplotype SNPs rs4821480, rs2032487 and rs4821481 were associated with kidney failure (OR 1.38-1.40 recessive, all P < 0.048).
|
19567477 |
2009 |
|
rs4821481
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Contrasting the 751 T2DM-ESRD cases with 227 T2DM non-nephropathy controls revealed that E1 haplotype SNPs rs4821480, rs2032487 and rs4821481 were associated with kidney failure (OR 1.38-1.40 recessive, all P < 0.048).
|
19567477 |
2009 |
|
rs1801282
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Cox's proportional hazard regression showed that both Pro12Ala and C161T polymorphisms were significant predictors of mortality in ESRD patients with DM (Pro12Ala: GG versus other genotypes, hazard ratio [HR] <0.01; P < 0.001; for C161T, CC versus TT genotypes, HR 2.86; P < 0.001; CT versus TT genotypes, HR 1.93; P < 0.001).
|
25784779 |
2015 |
|
rs1805192
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Cox's proportional hazard regression showed that both Pro12Ala and C161T polymorphisms were significant predictors of mortality in ESRD patients with DM (Pro12Ala: GG versus other genotypes, hazard ratio [HR] <0.01; P < 0.001; for C161T, CC versus TT genotypes, HR 2.86; P < 0.001; CT versus TT genotypes, HR 1.93; P < 0.001).
|
25784779 |
2015 |
|
rs188942711
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evidence that NPHS2-R229Q predisposes to proteinuria and renal failure in familial hematuria.
|
22228437 |
2012 |
|
rs61747728
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evidence that NPHS2-R229Q predisposes to proteinuria and renal failure in familial hematuria.
|
22228437 |
2012 |
|
rs754919065
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we describe a family where six members had a novel TRPC6 p.R68W (c.202C>T) mutation, two of whom had renal failure from FSGS, and one had proteinuria.
|
26147534 |
2015 |
|
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Homocysteine, folate, vitamin B12 levels, and C677T MTHFR mutation in children with renal failure.
|
12644913 |
2003 |
|
rs760336723
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the data do suggest that Wt1 R394W-induced glomerulosclerosis may be independent of downregulation of the genes for NPHS1, NPHS2, CD2AP, and podocalyxin and may involve other genes yet to be implicated in renal failure.
|
15509792 |
2004 |
|
rs1044498
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the extensively studied K121Q variant (rs1044498) did not reveal evidence for association with type 2 diabetic ESRD in this African-American population.
|
18184924 |
2008 |
|
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
However, we did not prove the hypothesis that MTHFR 677C --> T influences the risk of development of renal failure in the course of hypertension.
|
16280279 |
2005 |
|
rs3024912
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the individuals with the GG genotype at rs3024912 SNP may have a higher risk in kidney failure of MGN patients (adjusted odds ratio [OR]=3.255; 95% confidence interval [CI]=1.155-9.176, p=0.026).
|
21740896 |
2011 |
|
rs538166970
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, another mutant, R1180P, was compatible with life after transient neonatal renal insufficiency.
|
24163131 |
2014 |
|
rs7582694
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the case-only meta-analysis of the two cohorts, the STAT4 SNP rs7582694 was associated with severe renal insufficiency with p = 1.6 × 10(-3) and OR 2.22.
|
24386384 |
2013 |
|
rs367825197
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we report the identification of a heterozygous nonsense <i>PODXL</i> mutation (c.C976T; p. Arg326X) in a Chinese pedigree featured by proteinuria and renal insufficiency with AD inheritance by whole exome sequencing (WES).
|
30523047 |
2019 |
|
rs4362
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Influence of angiotensin converting enzyme (<i>ACE</i>) gene rs4362 polymorphism on the progression of kidney failure in patients with autosomal dominant polycystic kidney disease (ADPKD).
|
27748299 |
2016 |
|
rs2032487
|
|
|
0.020 |
GeneticVariation |
BEFREE |
MYH9 SNPs rs4821480, rs2032487, rs4281481 and rs3752462 are associated with T2DM-ESRD susceptibility in European Americans.
|
21968013 |
2012 |
|
rs4281481
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MYH9 SNPs rs4821480, rs2032487, rs4281481 and rs3752462 are associated with T2DM-ESRD susceptibility in European Americans.
|
21968013 |
2012 |
|
rs3752462
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MYH9 SNPs rs4821480, rs2032487, rs4281481 and rs3752462 are associated with T2DM-ESRD susceptibility in European Americans.
|
21968013 |
2012 |
|
rs3759126
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No correlation was found to exist between the AQP-2 gene polymorphism (rs3759126) and serum electrolyte levels in pre-ESRD patients (p = 0.38 for serum sodium level and p = 0.44 for serum potassium level).
|
17763164 |
2007 |