rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Sign of these predictive effects is opposite: subjects with MTHFR 677C>T polymorphism have lower likelihood of renal insufficiency; differently, wild-type MTHFR genotype subjects have lower GFR and greater hsCRP, iPTH, RRI, and LVH.
|
23534584 |
2013 |
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The MTHFR C677T polymorphism plays a significant role in predisposition of renal insufficiency in diabetic patients.
|
23846111 |
2013 |
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Obtained results indicate that C677T polymorphism is not associated with onset, duration and cause of kidney failure in our hemodialysis population.
|
20433440 |
2010 |
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
However, we did not prove the hypothesis that MTHFR 677C --> T influences the risk of development of renal failure in the course of hypertension.
|
16280279 |
2005 |
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The methylenetetrahydrofolate reductase 677 C/T genotypes were determined in 174 type 2 diabetic patients: 80 with and 94 without renal failure due to diabetic nephropathy.
|
12784186 |
2003 |
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Homocysteine, folate, vitamin B12 levels, and C677T MTHFR mutation in children with renal failure.
|
12644913 |
2003 |
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
While both renal failure and mutations of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene may result in hyperhomocysteinemia and CVD, the distinct roles of the thermolabile MTHFR mutation at nucleotide C677T and the more recently described mutation at nucleotide A1298C have not been evaluated concurrently in patients on hemodialysis.
|
12187094 |
2002 |
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The combined effect of renal failure and a common mutation (C677T) in the methylenetetrahydrofolate reductase gene that leads to serum homocysteine elevations in dialysis patients was investigated.
|
10770966 |
2000 |
rs1801282
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Cox's proportional hazard regression showed that both Pro12Ala and C161T polymorphisms were significant predictors of mortality in ESRD patients with DM (Pro12Ala: GG versus other genotypes, hazard ratio [HR] <0.01; P < 0.001; for C161T, CC versus TT genotypes, HR 2.86; P < 0.001; CT versus TT genotypes, HR 1.93; P < 0.001).
|
25784779 |
2015 |
rs1805192
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Cox's proportional hazard regression showed that both Pro12Ala and C161T polymorphisms were significant predictors of mortality in ESRD patients with DM (Pro12Ala: GG versus other genotypes, hazard ratio [HR] <0.01; P < 0.001; for C161T, CC versus TT genotypes, HR 2.86; P < 0.001; CT versus TT genotypes, HR 1.93; P < 0.001).
|
25784779 |
2015 |
rs2032487
|
|
|
0.020 |
GeneticVariation |
BEFREE |
MYH9 SNPs rs4821480, rs2032487, rs4281481 and rs3752462 are associated with T2DM-ESRD susceptibility in European Americans.
|
21968013 |
2012 |
rs2032487
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Contrasting the 751 T2DM-ESRD cases with 227 T2DM non-nephropathy controls revealed that E1 haplotype SNPs rs4821480, rs2032487 and rs4821481 were associated with kidney failure (OR 1.38-1.40 recessive, all P < 0.048).
|
19567477 |
2009 |
rs1801282
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The PPAR gamma 2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy.
|
18467141 |
2008 |
rs1805192
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The PPAR gamma 2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy.
|
18467141 |
2008 |
rs367825197
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we report the identification of a heterozygous nonsense <i>PODXL</i> mutation (c.C976T; p. Arg326X) in a Chinese pedigree featured by proteinuria and renal insufficiency with AD inheritance by whole exome sequencing (WES).
|
30523047 |
2019 |
rs118203979
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with p.G20D homozygous mutation in CLDN19 gene exhibit different progression to kidney failure suggesting that beyond the pathogenic mutation itself, other molecular events are favoring disease progression.
|
30305086 |
2018 |
rs4362
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Influence of angiotensin converting enzyme (<i>ACE</i>) gene rs4362 polymorphism on the progression of kidney failure in patients with autosomal dominant polycystic kidney disease (ADPKD).
|
27748299 |
2016 |
rs200640958
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two synonymous NPHS1 polymorphisms, rs2285450 (c.294C>T) and rs437168 (c.2289C>T) segregated with renal failure in this family.
|
26147534 |
2015 |
rs2285450
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two synonymous NPHS1 polymorphisms, rs2285450 (c.294C>T) and rs437168 (c.2289C>T) segregated with renal failure in this family.
|
26147534 |
2015 |
rs437168
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two synonymous NPHS1 polymorphisms, rs2285450 (c.294C>T) and rs437168 (c.2289C>T) segregated with renal failure in this family.
|
26147534 |
2015 |
rs437168
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two synonymous NPHS1 polymorphisms, rs2285450 (c.294C>T) and rs437168 (c.2289C>T) segregated with renal failure in this family.
|
26147534 |
2015 |
rs734553
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The strongest genetic marker of uric acid levels, the rs734553 SNP in the GLUT9 urate transporter gene, predicts progression to kidney failure in CKD patients and associates with systolic BP and carotid intima media thickness in family-based studies.
|
26607700 |
2015 |
rs754919065
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we describe a family where six members had a novel TRPC6 p.R68W (c.202C>T) mutation, two of whom had renal failure from FSGS, and one had proteinuria.
|
26147534 |
2015 |
rs538166970
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, another mutant, R1180P, was compatible with life after transient neonatal renal insufficiency.
|
24163131 |
2014 |
rs104886303
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The L1649R mutation in the COL4A5 gene causes a relatively mild form of XLAS characterized by late-onset renal failure and less frequent, severe temporal macular thinning relative to other COL4A5 mutations.
|
23572034 |
2013 |