|
rs11846409
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania.
|
28492228 |
2017 |
|
rs200931578
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania.
|
28492228 |
2017 |
|
rs201076896
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania.
|
28492228 |
2017 |
|
rs201691548
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania.
|
28492228 |
2017 |
|
rs202117805
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania.
|
28492228 |
2017 |
|
rs202166511
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania.
|
28492228 |
2017 |
|
rs5743708
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Although Arg753Gln polymorphism of the TLR2 gene was considered to be related to acute rheumatic fever susceptibility in child, two groups have identified that there were no relations between this Arg753Gln polymorphism and rheumatic heart disease susceptibility.
|
25487598 |
2015 |
|
rs5743708
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, TLR2 gene Arg753Gln polymorphism is not associated with BD nor with RHD; and a duplicated region of the TLR2 exon 3 located 23-kb upstream of the polymorphic region may explain contradictory association findings described so far.
|
19693643 |
2009 |
|
rs5743708
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The lack of genetic association of the Toll-like receptor 2 (TLR2) Arg753Gln and Arg677Trp polymorphisms with rheumatic heart disease.
|
17096074 |
2007 |
|
rs2476601
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, G rs2476601 A rs1217406 T rs3789609 haplotype turned out to be a low risk factor for RHD (P = 0.0042) predisposition in females and adult patients.
|
25273327 |
2014 |
|
rs2476601
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results demonstrated that the PTPN22 R620W polymorphism is not associated with RHD nor with SLE in Turkish population.
|
21384170 |
2011 |
|
rs10889677
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the IL17F (rs763780) and IL23R (rs10889677) polymorphisms did not show any association with RHD.
|
29985710 |
2018 |
|
rs1799750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that rs1799750 in MMP1 might be a risk factor for RHD in a Han population in Southern China, and individuals carrying the 2G/2G genotype are likely more susceptible to RHD.
|
29458338 |
2018 |
|
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results suggest that IL17A (rs2275913) polymorphism is associated with the development of RF/RHD in South Indian population.
|
29985710 |
2018 |
|
rs2276109
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, rs3025058 in MMP3 and rs2276109 in MMP12 might not contribute to the risk of developing RHD in this population.
|
29458338 |
2018 |
|
rs3025058
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, rs3025058 in MMP3 and rs2276109 in MMP12 might not contribute to the risk of developing RHD in this population.
|
29458338 |
2018 |
|
rs763780
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the IL17F (rs763780) and IL23R (rs10889677) polymorphisms did not show any association with RHD.
|
29985710 |
2018 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This is the first study to investigate the association between the MTHFR C677T polymorphism and risk of RHD.
|
26813460 |
2016 |
|
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations of 8 selected polymorphisms in seven inflammatory genes: IL-6 [rs1800795G/C], IL-10 [rs1800896G/A], TNF-A [rs1800629G/A], IL-1β [rs2853550C/T], IL-1VNTR [rs2234663], TGF-β1 [rs1800469C/T]; [rs1982073T/C], and CTLA-4 [rs5742909C/T] with RHD risk.
|
27118427 |
2016 |
|
rs1800795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations of 8 selected polymorphisms in seven inflammatory genes: IL-6 [rs1800795G/C], IL-10 [rs1800896G/A], TNF-A [rs1800629G/A], IL-1β [rs2853550C/T], IL-1VNTR [rs2234663], TGF-β1 [rs1800469C/T]; [rs1982073T/C], and CTLA-4 [rs5742909C/T] with RHD risk.
|
27118427 |
2016 |
|
rs1800797
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The IL-6 promoter rs1800797 (-597G/A) SNP may influence susceptibility to RHD of people of Māori and Pacific ancestry living in NZ.
|
27400406 |
2016 |
|
rs1800896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations of 8 selected polymorphisms in seven inflammatory genes: IL-6 [rs1800795G/C], IL-10 [rs1800896G/A], TNF-A [rs1800629G/A], IL-1β [rs2853550C/T], IL-1VNTR [rs2234663], TGF-β1 [rs1800469C/T]; [rs1982073T/C], and CTLA-4 [rs5742909C/T] with RHD risk.
|
27118427 |
2016 |
|
rs1982073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations of 8 selected polymorphisms in seven inflammatory genes: IL-6 [rs1800795G/C], IL-10 [rs1800896G/A], TNF-A [rs1800629G/A], IL-1β [rs2853550C/T], IL-1VNTR [rs2234663], TGF-β1 [rs1800469C/T]; [rs1982073T/C], and CTLA-4 [rs5742909C/T] with RHD risk.
|
27118427 |
2016 |
|
rs1982073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multifactor dimensionality reduction and classification and regression tree approaches were combined with logistic regression to discover high-order gene-gene interactions in studiedgenes involved in RHD susceptibility.In univariate logistic regression analysis, we found significant association of variant-containing genotypes (CT&TT) of TGF-β1 869T/C [rs1982073]; [p=0.0.004 & 0.001, OR (95% CI)=1.65 (1.2-2.3) & 2.25 (1.4-3.6) respectively], variant genotype (CC) of IL-1β -511C/T [rs2853550]; [p=0.001, OR (95% CI)=2.33 (1.4-3.8)] and IL-1 VNTR [rs2234663]; [p=0.03, OR (95% CI)=5.25 (1.2-23.4)] SNPs with RHD risk.
|
27118427 |
2016 |
|
rs2234663
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multifactor dimensionality reduction and classification and regression tree approaches were combined with logistic regression to discover high-order gene-gene interactions in studiedgenes involved in RHD susceptibility.In univariate logistic regression analysis, we found significant association of variant-containing genotypes (CT&TT) of TGF-β1 869T/C [rs1982073]; [p=0.0.004 & 0.001, OR (95% CI)=1.65 (1.2-2.3) & 2.25 (1.4-3.6) respectively], variant genotype (CC) of IL-1β -511C/T [rs2853550]; [p=0.001, OR (95% CI)=2.33 (1.4-3.8)] and IL-1 VNTR [rs2234663]; [p=0.03, OR (95% CI)=5.25 (1.2-23.4)] SNPs with RHD risk.
|
27118427 |
2016 |