|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Then in the present study, we performed the linkage disequilibrium to determine the association between three genetic variants (SNPs: rs3924999, rs2954041, SNP8NRG221533) on NRG1 gene and schizophrenia in 246 Chinese Han schizophrenic family trios using PCR-based restriction fragment length polymorphism method and denaturing high-performance liquid chromatography.
|
12874607 |
2003 |
|
rs2954041
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Then in the present study, we performed the linkage disequilibrium to determine the association between three genetic variants (SNPs: rs3924999, rs2954041, SNP8NRG221533) on NRG1 gene and schizophrenia in 246 Chinese Han schizophrenic family trios using PCR-based restriction fragment length polymorphism method and denaturing high-performance liquid chromatography.
|
12874607 |
2003 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
On the basis of the contrast between the findings of other study and our family-based study and the negative findings of our case-control association study, we conclude that NRG1 Arg38Gln polymorphism is not likely to play a major role in the pathogenesis of schizophrenia in Chinese populations.
|
15276238 |
2004 |
|
rs1081062
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There were no significant differences in allele frequencies for each SNP between cases and controls, however, homozygotes of minor alleles in SNP8NRG241930, SNP8NRG243177, and rs1081062 were associated with an increased risk of schizophrenia (P=0.025, OR=4.14; P=0.041, OR=1.43; and P=0.0023, OR=3.06, respectively).
|
16326006 |
2006 |
|
rs367543150
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A novel Neuregulin 1 (NRG1) missense variant (exon 11 G>T) was recently associated with psychosis and schizophrenia (SCZ) in the same population isolate.
|
17519028 |
2007 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We were unable to replicate previous associations of rs6994992 with schizophrenia and, moreover, did not find significant associations with age of onset, an estimate of pre-morbid IQ, or neurocognition.
|
18286587 |
2008 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A missense mutation on rs3924999 of the neuregulin 1 gene may have a functional effect on prepulse inhibition in both schizophrenia and healthy control populations.
|
17631867 |
2008 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia.
|
18543275 |
2009 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, taking into account the rs6994992 SNP in the NRG1 gene, which was also associated with LV volume in a previous study, the DISC1 SNP only predicted LV enlargement among those patients carrying the T allele in the NRG1 SNP.
|
19913623 |
2010 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
These findings indicate that NRG1 rs3924999 affects spatial accuracy on the AS task, suggesting an influence of the gene on the neural mechanisms underlying visuospatial sensorimotor transformations, a mechanism that has been previously found to be impaired in patients with schizophrenia and their relatives.
|
20497232 |
2010 |
|
rs3757930
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No evidence was found for association in the new samples when analysed individually; however, in the joint analysis of the two Scottish samples, a region B haplotype comprising two SNPs (rs6988339 and rs3757930) was associated with SCZ and the combined case group (SCZ: p=0.0037, OR=1.3, 95% CI: 1.1-1.6; BPD+SCZ: p=0.0080, OR=1.2, 95% CI: 1.1-1.5), with these associations withstanding multiple testing correction at the single-test level (SCZ: p(st)=0.022; BPD+SCZ: p(st)=0.044).
|
20435087 |
2010 |
|
rs3802160
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed interaction between NRG1 5' and 3' SNPs rs4560751 and rs3802160 (likelihood ratio test P = .00020) and schizophrenia, which was validated using functional magnetic resonance imaging of working memory in healthy controls; carriers of risk-associated genotypes showed inefficient processing in the dorsolateral prefrontal cortex (P = .015, familywise error corrected).
|
20921115 |
2010 |
|
rs4560751
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed interaction between NRG1 5' and 3' SNPs rs4560751 and rs3802160 (likelihood ratio test P = .00020) and schizophrenia, which was validated using functional magnetic resonance imaging of working memory in healthy controls; carriers of risk-associated genotypes showed inefficient processing in the dorsolateral prefrontal cortex (P = .015, familywise error corrected).
|
20921115 |
2010 |
|
rs6988339
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No evidence was found for association in the new samples when analysed individually; however, in the joint analysis of the two Scottish samples, a region B haplotype comprising two SNPs (rs6988339 and rs3757930) was associated with SCZ and the combined case group (SCZ: p=0.0037, OR=1.3, 95% CI: 1.1-1.6; BPD+SCZ: p=0.0080, OR=1.2, 95% CI: 1.1-1.5), with these associations withstanding multiple testing correction at the single-test level (SCZ: p(st)=0.022; BPD+SCZ: p(st)=0.044).
|
20435087 |
2010 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective of this cross-sectional genetic association study was to determine the relationship of six core single-nucleotide polymorphisms within the NRG1 gene identified as promising schizophrenia risk genes (rs6994992, SNP8NRG221132, SNP8NRG241930, rs3924999, rs2439272 and rs10503929) to prepulse inhibition (PPI) of the acoustic startle reflex, a well validated schizophrenia endophenotype.
|
21035784 |
2011 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The objective of this cross-sectional genetic association study was to determine the relationship of six core single-nucleotide polymorphisms within the NRG1 gene identified as promising schizophrenia risk genes (rs6994992, SNP8NRG221132, SNP8NRG241930, rs3924999, rs2439272 and rs10503929) to prepulse inhibition (PPI) of the acoustic startle reflex, a well validated schizophrenia endophenotype.
|
21035784 |
2011 |
|
rs10503929
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The objective of this cross-sectional genetic association study was to determine the relationship of six core single-nucleotide polymorphisms within the NRG1 gene identified as promising schizophrenia risk genes (rs6994992, SNP8NRG221132, SNP8NRG241930, rs3924999, rs2439272 and rs10503929) to prepulse inhibition (PPI) of the acoustic startle reflex, a well validated schizophrenia endophenotype.
|
21035784 |
2011 |
|
rs74942016
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As there are no data for V266L in Chinese, and given the potential relevance of this mutation, we investigated the V266L prevalence in 270 Chinese patients with schizophrenia and 270 ethnically matched controls.
|
20978455 |
2011 |
|
rs10503899
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Multifaceted genomic risk for brain function in schizophrenia.
|
22440650 |
2012 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The G/G carriers of rs3924999 tended to perform worse in the P300 latency as compared to A/A or A/G carriers both in the schizophrenia and controls.
|
22467496 |
2012 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three variants and one microsatellite showed allelic association with SZ (rs35753505, rs4733263, rs6994992, and microsatellite 420M9-1395, p≤0.05 uncorrected for multiple comparisons).
|
23360725 |
2013 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We failed to demonstrate a significant association between rs2954041 and rs3924999 with schizophrenia in the three ethnic groups studied (Malay, Chinese, and Indian), while rs764059 was found to be monomorphic.
|
23489597 |
2013 |
|
rs2954041
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We failed to demonstrate a significant association between rs2954041 and rs3924999 with schizophrenia in the three ethnic groups studied (Malay, Chinese, and Indian), while rs764059 was found to be monomorphic.
|
23489597 |
2013 |
|
rs764059
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We failed to demonstrate a significant association between rs2954041 and rs3924999 with schizophrenia in the three ethnic groups studied (Malay, Chinese, and Indian), while rs764059 was found to be monomorphic.
|
23489597 |
2013 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Homozygosity for the schizophrenia risk allele (T) of rs6994992 conferred lower cortical NRG1-IVNV levels.
|
24935406 |
2014 |