|
rs17673138
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.
|
25944848 |
2015 |
|
rs10503899
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Multifaceted genomic risk for brain function in schizophrenia.
|
22440650 |
2012 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, since NRG1 rs6994992 is not a schizophrenia risk variant in the Han Chinese population, the validated association suggested that ethnic difference may exist in the relationship between NRG1 rs6994992, schizophrenia and creativity.
|
31649580 |
2019 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional polymorphism (SNP8NRG243177/rs6994992; C/T) in the promoter region of the brain-specific type IV neuregulin-1 gene ( NRG1) has been associated with psychiatric disorders (e.g. schizophrenia and bipolar disorder) that often present higher odds of smoking, alcohol and illicit drug use.
|
27353026 |
2017 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To determine the genetic association between qualitative and quantitative traits of autism spectrum disorder (ASD) and neuregulin 1 (NRG1)-a schizophrenia candidate gene-we examined six single nucleotide polymorphisms (SNPs) in NRG1 using a family-based association test (FBAT) in Korean families with ASD. rs35753505 and rs6994992 SNPs in NRG1 revealed a statistically significant family-based association with three quantitative traits for sociality.
|
25858800 |
2015 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Homozygosity for the schizophrenia risk allele (T) of rs6994992 conferred lower cortical NRG1-IVNV levels.
|
24935406 |
2014 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Schizophrenia-risk variant rs6994992 in the neuregulin-1 gene on brain developmental trajectories in typically developing children.
|
24865593 |
2014 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three variants and one microsatellite showed allelic association with SZ (rs35753505, rs4733263, rs6994992, and microsatellite 420M9-1395, p≤0.05 uncorrected for multiple comparisons).
|
23360725 |
2013 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective of this cross-sectional genetic association study was to determine the relationship of six core single-nucleotide polymorphisms within the NRG1 gene identified as promising schizophrenia risk genes (rs6994992, SNP8NRG221132, SNP8NRG241930, rs3924999, rs2439272 and rs10503929) to prepulse inhibition (PPI) of the acoustic startle reflex, a well validated schizophrenia endophenotype.
|
21035784 |
2011 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, taking into account the rs6994992 SNP in the NRG1 gene, which was also associated with LV volume in a previous study, the DISC1 SNP only predicted LV enlargement among those patients carrying the T allele in the NRG1 SNP.
|
19913623 |
2010 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia.
|
18543275 |
2009 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We were unable to replicate previous associations of rs6994992 with schizophrenia and, moreover, did not find significant associations with age of onset, an estimate of pre-morbid IQ, or neurocognition.
|
18286587 |
2008 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
For NRG1 polymorphisms, in the early onset subgroup (≤25years), the rs3924999 G/G genotype was susceptible to schizophrenia</span>.
|
27236031 |
2016 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our study established a significant association of rs35753505 with schizophrenia but no association with rs3924999 and rs2954041.
|
25106628 |
2014 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We failed to demonstrate a significant association between rs2954041 and rs3924999 with schizophrenia in the three ethnic groups studied (Malay, Chinese, and Indian), while rs764059 was found to be monomorphic.
|
23489597 |
2013 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The G/G carriers of rs3924999 tended to perform worse in the P300 latency as compared to A/A or A/G carriers both in the schizophrenia and controls.
|
22467496 |
2012 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The objective of this cross-sectional genetic association study was to determine the relationship of six core single-nucleotide polymorphisms within the NRG1 gene identified as promising schizophrenia risk genes (rs6994992, SNP8NRG221132, SNP8NRG241930, rs3924999, rs2439272 and rs10503929) to prepulse inhibition (PPI) of the acoustic startle reflex, a well validated schizophrenia endophenotype.
|
21035784 |
2011 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
These findings indicate that NRG1 rs3924999 affects spatial accuracy on the AS task, suggesting an influence of the gene on the neural mechanisms underlying visuospatial sensorimotor transformations, a mechanism that has been previously found to be impaired in patients with schizophrenia and their relatives.
|
20497232 |
2010 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A missense mutation on rs3924999 of the neuregulin 1 gene may have a functional effect on prepulse inhibition in both schizophrenia and healthy control populations.
|
17631867 |
2008 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
On the basis of the contrast between the findings of other study and our family-based study and the negative findings of our case-control association study, we conclude that NRG1 Arg38Gln polymorphism is not likely to play a major role in the pathogenesis of schizophrenia in Chinese populations.
|
15276238 |
2004 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Then in the present study, we performed the linkage disequilibrium to determine the association between three genetic variants (SNPs: rs3924999, rs2954041, SNP8NRG221533) on NRG1 gene and schizophrenia in 246 Chinese Han schizophrenic family trios using PCR-based restriction fragment length polymorphism method and denaturing high-performance liquid chromatography.
|
12874607 |
2003 |
|
rs10503929
|
|
|
0.030 |
GeneticVariation |
BEFREE |
After adding new reports, the T-allele of NRG1 SNP8NRG241930 (rs62510682) across all studies (OR = 0.95, 95% CI = 0.91-0.997, p = 0.04, N = 22,898) and in Caucasian samples (OR = 0.95, 95% CI = 0.90-0.99, p = 0.03, N = 16,014), and the C-allele of NRG1 rs10503929 across all studies (OR = 0.89, 95% CI = 0.81-0.97, p = 0.01, N = 6844) and in Caucasian samples (OR = 0.89, 95% CI = 0.81-0.98, p = 0.01, N = 6414) were protective against schizophrenia.
|
28864885 |
2018 |
|
rs10503929
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To further support the utility of this phenotype, we studied its test-retest reliability, its potential brain structural contributions, and the effects of a protective missense variant in neuregulin 1 (NRG1) linked to schizophrenia by meta-analysis (ie, rs10503929).
|
24622944 |
2014 |
|
rs2954041
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our study established a significant association of rs35753505 with schizophrenia but no association with rs3924999 and rs2954041.
|
25106628 |
2014 |
|
rs2954041
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We failed to demonstrate a significant association between rs2954041 and rs3924999 with schizophrenia in the three ethnic groups studied (Malay, Chinese, and Indian), while rs764059 was found to be monomorphic.
|
23489597 |
2013 |