|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A statistically significant association between a silent mutation (102T/C) in the serotonin-2A (5-HT2A) receptor gene and schizophrenia has recently been reported in a sample of Japanese patients and healthy controls.
|
8655141 |
1996 |
|
rs6311
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A total of 7 gene polymorphisms from DRD2 (rs1800497, rs1079597, rs1800498, rs1801028) and 5-HT2 A (rs6313, rs6311, rs6305) were genotyped for their association with schizophrenia.
|
30389402 |
2019 |
|
rs6305
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A total of 7 gene polymorphisms from DRD2 (rs1800497, rs1079597, rs1800498, rs1801028) and 5-HT2 A (rs6313, rs6311, rs6305) were genotyped for their association with schizophrenia.
|
30389402 |
2019 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although association studies between MspI polymorphism (T102C) and the 5-HT2a receptor gene and schizophrenia have been reported, their results are still controversial.
|
9694252 |
1998 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Another 5-HT(2A) receptor polymorphism consists of the silent thymidine-cytosine substitution (102T>C), which has been controversially associated with schizophrenia.
|
15037867 |
2004 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. European Multicentre Association Study of Schizophrenia (EMASS) Group.
|
8622505 |
1996 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between T102C and A-1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs.
|
17617023 |
2007 |
|
rs7322347
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of rs4680 <i>COMT</i>, rs6280 <i>DRD3</i>, and rs7322347 <i>5HT2A</i> With Clinical Features of Youth-Onset Schizophrenia.
|
31798476 |
2019 |
|
rs75634836
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on the pivotal role ascribed to the prefrontal executive control network for absorbed attention and positive symptoms in schizophrenia, it was further hypothesized that Absorption is associated with the VAL158MET polymorphism of the catechol-O-methyltransferase (COMT) gene affecting the dopaminergic neurotransmitter system.
|
15965969 |
2005 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Case-control association studies have identified the T102C polymorphism of the 5-HT2A receptor gene as being associated with schizophrenia and responsiveness to clozapine.
|
11526996 |
2001 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Could HTR2A T102C and DRD3 Ser9Gly predict clinical improvement in patients with acutely exacerbated schizophrenia? Results from treatment responses to risperidone in a naturalistic setting.
|
17924589 |
2008 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Cytosine methylation of HTR2A at T102C polymorphic site in DNA derived from the saliva can potentially be used as a diagnostic, prognostic, and/or therapeutic biomarker in SCZ and BD.
|
21598376 |
2011 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Differential expression and parent-of-origin effect of the 5-HT2A receptor gene C102T polymorphism: analysis of suicidality in schizophrenia and bipolar disorder.
|
17221840 |
2007 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Forty-nine patients, with schizophrenia or schizoaffective disorder and treated with clozapine (n = 22) or olanzapine (n = 27), were evaluated for fasting levels of C-peptide, insulin and blood glucose, homeostasis model assessment index for insulin resistance (HOMA-IR) and body mass index (BMI), and genotyped for the -1438A/G, -783A/G, 102T/C, and His452Tyr polymorphisms of the HTR2A gene.
|
20521326 |
2010 |
|
rs6314
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Forty-nine patients, with schizophrenia or schizoaffective disorder and treated with clozapine (n = 22) or olanzapine (n = 27), were evaluated for fasting levels of C-peptide, insulin and blood glucose, homeostasis model assessment index for insulin resistance (HOMA-IR) and body mass index (BMI), and genotyped for the -1438A/G, -783A/G, 102T/C, and His452Tyr polymorphisms of the HTR2A gene.
|
20521326 |
2010 |
|
rs1805055
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four polymorphisms (two structural changes, Thr25Asn and His4 M52Tyr, and two silent polymorphisms, 102-T/C and 516-C/T) which had previously been found in patients with schizophrenia and control subjects were detected.
|
9086465 |
1997 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a further analysis by ethnicity, the OR and 95% CIs indicated the T102C polymorphism was not associated with MDD, BPD, or SCZ in Caucasian, Asian or Chinese populations.
|
24962835 |
2014 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our replication study provides further evidence for association between the 5-HTR2A receptor T102C polymorphism and schizophrenia.
|
17240119 |
2007 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the meta-analysis of 31 case-control association studies, we found a significant association between the C allele of the T102C polymorphism and schizophrenia, which was more pronounced in European samples than in the entire sample.
|
14741324 |
2004 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study, we investigated the potential influence of the T102C polymorphism on the psychopathology of schizophrenia.
|
10686558 |
2000 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interestingly, promoter DNA of HTR2A was hypermethylated at and around the -1438A/G polymorphic site, but was hypomethylated at and around T102C polymorphic site in SCZ and BD compared to the controls.
|
21550210 |
2011 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analyses of pooled ORs support association of schizophrenia to the Ser311Cys polymorphism in DRD2 and the T102C polymorphism in HTR2A, and of attention deficit hyperactivity disorder to the 48-bp repeat in DRD4.
|
15802092 |
2005 |
|
rs6314
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Moreover, we found that rs1076560 T carrier/rs6314 CC individuals had better responses to antipsychotic treatment in two independent samples of patients with schizophrenia (n=63 and n=54, respectively), consistent with the previously reported separate effects of these genotypes.
|
25563748 |
2015 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data do not support an allelic association between the 102T/C polymorphism of the 5-HT2A receptor gene and schizophrenia in Chinese population.
|
9264136 |
1997 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings are consistent with other recent association studies which argue against the involvement of the 5-HT2a/T102C polymorphism in predisposition to schizophrenia.
|
9259371 |
1997 |