|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To explore further, the present study aimed to assess the influence of DRD2 -141 C Ins/Del, Taq1A and HTR2A -1438 G/A, 102T/C and HTR2C -759 C/T genetic polymorphisms in response to risperidone in patients with schizophrenia.
|
30332506 |
2019 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis indicates that rs6311 and rs6313 polymorphisms of 5-HT<sub>2A</sub>R are not associated with schizophrenia.
|
27598719 |
2017 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three CpG sites were hypermethylated in schizophrenia (cg5 <i>p</i> = 0.028, cg7 <i>p</i> = 0.021, cg10 <i>p</i> = 0.017) and <i>HTR2A</i> polymorphisms rs6314 (<i>p</i> = 0.008) and rs6313 (<i>p</i> = 0.026) showed genetic association with schizophrenia.
|
28054990 |
2017 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study indicated an association between the SNPs (rs6311 and rs6313) of the serotonin receptor 5HT2A and schizophrenia.
|
25758572 |
2014 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a further analysis by ethnicity, the OR and 95% CIs indicated the T102C polymorphism was not associated with MDD, BPD, or SCZ in Caucasian, Asian or Chinese populations.
|
24962835 |
2014 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the HTR2A T102C polymorphism may confer susceptibility to schizophrenia in Han Chinese.
|
23857788 |
2013 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of the study was to investigate whether the 5-HT2A receptor gene's polymorphisms (His452Tyr and T102C) have an influence on the response to olanzapine in patients with schizophrenia.
|
21912188 |
2011 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interestingly, promoter DNA of HTR2A was hypermethylated at and around the -1438A/G polymorphic site, but was hypomethylated at and around T102C polymorphic site in SCZ and BD compared to the controls.
|
21550210 |
2011 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Cytosine methylation of HTR2A at T102C polymorphic site in DNA derived from the saliva can potentially be used as a diagnostic, prognostic, and/or therapeutic biomarker in SCZ and BD.
|
21598376 |
2011 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Forty-nine patients, with schizophrenia or schizoaffective disorder and treated with clozapine (n = 22) or olanzapine (n = 27), were evaluated for fasting levels of C-peptide, insulin and blood glucose, homeostasis model assessment index for insulin resistance (HOMA-IR) and body mass index (BMI), and genotyped for the -1438A/G, -783A/G, 102T/C, and His452Tyr polymorphisms of the HTR2A gene.
|
20521326 |
2010 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The serotonin 2A (5-HT2A) receptor gene has been implicated in the pathogenesis of suicidal behaviour by a genetic association between the 5-HT2A T102C silent polymorphism and suicidality in patients with mood disorders and schizophrenia.
|
18783799 |
2009 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have recently shown that the linked serotonin-2A receptor (5-HT(2A)R) A-1438 G and T102C polymorphisms modulate PPI in schizophrenia patients.
|
19545856 |
2009 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
While further research into the molecular mechanisms underlying this interaction is needed, our results underscore the role of 5-HTR in PPI modulation and further implicate the 5-HTR1A G-1019C and the 5-HTR2A T102C polymorphisms in the pathophysiology of schizophrenia.
|
19352591 |
2009 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study investigated whether the efficacy of aripiprazole can be predicted by functional HTR2A A-1438G/T102C polymorphisms (rs63311/rs6313) as modified by clinical factors in Han Chinese hospitalized patients with acutely exacerbated schizophrenia.
|
19387614 |
2009 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that PPI and habituation are modulated by 5-HT(2A)R A-1438G and T102C genotype in schizophrenia.
|
18420180 |
2008 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Could HTR2A T102C and DRD3 Ser9Gly predict clinical improvement in patients with acutely exacerbated schizophrenia? Results from treatment responses to risperidone in a naturalistic setting.
|
17924589 |
2008 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association between the T102C polymorphism on the 5HT2A gene and cognitive function as well as clinical manifestations in patients with schizophrenia.
|
17221846 |
2007 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between T102C and A-1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs.
|
17617023 |
2007 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Differential expression and parent-of-origin effect of the 5-HT2A receptor gene C102T polymorphism: analysis of suicidality in schizophrenia and bipolar disorder.
|
17221840 |
2007 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our replication study provides further evidence for association between the 5-HTR2A receptor T102C polymorphism and schizophrenia.
|
17240119 |
2007 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no genetic association between HTR2A T102C with either schizophrenia or bipolar disorder under the assumption of a parent-of-origin effect, and these data together essentially exclude imprinting at this locus as a potential explanation for the complex inheritance observed in major psychoses.
|
17407792 |
2007 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate (i) the association between four serotonergic polymorphisms (A-1438G and T102C of the 5-HT2A receptor gene, and 5-HTT VNTR and 5-HTTLPR of the 5-HT transporter gene) and schizophrenia and (ii) the potential interaction of those polymorphisms in the development of schizophrenia.
|
17291660 |
2007 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We performed primer extension assays to measure relative expression of allele-specific HTR2A transcripts in mRNAs isolated from the prefrontal cortex of 31 individuals with schizophrenia and from peripheral lymphocytes (PBLs) of 31 healthy individuals heterozygous for 102T/C.
|
17069769 |
2006 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We detected 7 single nucleotide polymorphisms (SNPs) on 13q14, one (rs6313) present at the HTR2A locus and the other 6 at the KPNA3 locus, among 124 British family trios consisting of mother, father and affected offspring with schizophrenia.
|
15882913 |
2005 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies suggest that the 5-hydroxytryptamine receptor 2A (5-HT2A) gene (HTR2A) T102C and G-1438A polymorphisms may influence treatment response of risperidone or olanzapine for schizophrenia's negative symptoms (e.g., blunted affect and social withdrawal).
|
15882132 |
2005 |