|
rs2793092
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T/T genotype of rs2793092 SNP in DISC1 was significantly associated with increased LV volume.
|
19913623 |
2010 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The schizophrenia risk variant S704C affects the formation of octamers of DISC1 and exhibits higher-order self-oligomerization.
|
21998303 |
2011 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In contrast to the significant effect on prefrontal activation we had previously found in healthy subjects, no significant effect of Cys704Ser was detected in this or any other region in either the schizophrenia or bipolar groups.
|
21091867 |
2011 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three common missense variants of the Disrupted in Schizophrenia 1 (DISC1) gene, rs3738401 (Q264R), rs6675281 (L607F) and rs821616 (S704C), have been variably associated with the risk of schizophrenia.
|
20531374 |
2011 |
|
rs6675281
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Three common missense variants of the Disrupted in Schizophrenia 1 (DISC1) gene, rs3738401 (Q264R), rs6675281 (L607F) and rs821616 (S704C), have been variably associated with the risk of schizophrenia.
|
20531374 |
2011 |
|
rs3738401
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Three common missense variants of the Disrupted in Schizophrenia 1 (DISC1) gene, rs3738401 (Q264R), rs6675281 (L607F) and rs821616 (S704C), have been variably associated with the risk of schizophrenia.
|
20531374 |
2011 |
|
rs1538979
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Moreover, there was an effect of SNP rs1538979 in the pre/postcentral gyrus with decreased activation in healthy controls and increased activation in patients with schizophrenia.
|
21376542 |
2011 |
|
rs821633
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Three risk variants (rs1538979, rs821577, and rs821633) in the Disrupted-in-Schizophrenia-1 (DISC1) gene have previously been associated with both schizophrenia and bipolar disorder in a recent collaborative analysis of European cohorts.
|
21376542 |
2011 |
|
rs821577
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three risk variants (rs1538979, rs821577, and rs821633) in the Disrupted-in-Schizophrenia-1 (DISC1) gene have previously been associated with both schizophrenia and bipolar disorder in a recent collaborative analysis of European cohorts.
|
21376542 |
2011 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two-locus analysis showed C-C (rs766288-rs2812393) as a risk combination in BPAD, and G-T (rs2812393-rs821616) as a protective combination in SCZ and combined cases of BPAD or SCZ.
|
22673686 |
2012 |
|
rs821597
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The DISC1 variant rs821597 may confer risk for schizophrenia by its effects on the regional GM in left parahippocampal gyrus and right orbitofrontal cortex with other risk factors for schizophrenia.
|
22516458 |
2012 |
|
rs6675281
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We sought to examine the effects of the DISC1 Leu(607) Phe polymorphism on brain activation in young healthy individuals at familial risk of bipolar disorder (n = 84), in a group of controls (n = 78), and in a group at familial risk of schizophrenia (n = 47), performing a language task.
|
22337479 |
2012 |
|
rs2812393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two-locus analysis showed C-C (rs766288-rs2812393) as a risk combination in BPAD, and G-T (rs2812393-rs821616) as a protective combination in SCZ and combined cases of BPAD or SCZ.
|
22673686 |
2012 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We performed a meta-analysis of the Ser704Cys variant in schizophrenia using data from the present study and five previous Japanese population studies, and found no association with schizophrenia.
|
24013095 |
2013 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, we investigated the brain anatomical networks of 278 healthy volunteers with different genotypes in the common missense variant (Ser704Cys) of the Disrupted-in-Schizophrenia-1 (DISC1) gene, which is one of the main susceptibility genes of schizophrenia and other psychiatric disorders.
|
22693340 |
2013 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No significant relationship was found between the -274G>C, c.791G>A, and c.2110A>T haplotypes and development of different acute symptoms of schizophrenia.
|
23347445 |
2013 |
|
rs569395146
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant relationship was found between the -274G>C, c.791G>A, and c.2110A>T haplotypes and development of different acute symptoms of schizophrenia.
|
23347445 |
2013 |
|
rs776420091
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant relationship was found between the -274G>C, c.791G>A, and c.2110A>T haplotypes and development of different acute symptoms of schizophrenia.
|
23347445 |
2013 |
|
rs821621
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we explored the association between DISC1 missense mutation rs821616 (Ser704Cys) single nucleotide polymorphism (SNP) and four other SNPs (rs1772702, rs1754603, rs821621, rs821624) in the related haplotype block and schizophrenia in the Japanese population.
|
24013095 |
2013 |
|
rs821624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we explored the association between DISC1 missense mutation rs821616 (Ser704Cys) single nucleotide polymorphism (SNP) and four other SNPs (rs1772702, rs1754603, rs821621, rs821624) in the related haplotype block and schizophrenia in the Japanese population.
|
24013095 |
2013 |
|
rs373288445
|
|
|
0.010 |
GeneticVariation |
BEFREE |
D2R-DISC1 complex levels are increased in conjunction with decreased GSK-3α/β (Ser21/9) phosphorylation in both postmortem brain tissue from schizophrenia patients and in Disc1-L100P mutant mice, an animal model with behavioral abnormalities related to schizophrenia.
|
25433637 |
2014 |
|
rs773758385
|
|
|
0.010 |
GeneticVariation |
BEFREE |
D2R-DISC1 complex levels are increased in conjunction with decreased GSK-3α/β (Ser21/9) phosphorylation in both postmortem brain tissue from schizophrenia patients and in Disc1-L100P mutant mice, an animal model with behavioral abnormalities related to schizophrenia.
|
25433637 |
2014 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects.
|
25092219 |
2015 |
|
rs821597
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Polymorphisms in DISC1 gene showed only marginally statistically significant association with schizophrenia (rs17817356) or no association whatsoever (rs821597 and rs980989) while two polymorphisms (rs9661837 and rs3737597) were found to be only slightly polymorphic in the samples.
|
25889058 |
2015 |
|
rs3737597
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Polymorphisms in DISC1 gene showed only marginally statistically significant association with schizophrenia (rs17817356) or no association whatsoever (rs821597 and rs980989) while two polymorphisms (rs9661837 and rs3737597) were found to be only slightly polymorphic in the samples.
|
25889058 |
2015 |