|
rs1049353
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Seven out of the 32 tSNPs within PPARA (rs4253765, rs4263776, rs6007662, rs1800206, rs4253763, rs6008197 and rs4253655) and 3 out of 12 tSNPs within CNR1 (rs1049353, rs7766029 and rs806366) were nominally associated with SZ (uncorrected p<0.05).
|
22920733 |
2013 |
|
rs1049353
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The possible role of a tag SNP (the 1359G/A polymorphism) of the gene encoding the cannabinoid receptor type 1 (CNR1) in schizophrenia and/or therapeutic response to atypical antipsychotics was assessed in a cohort of 133 French schizophrenic patients compared to 141 normal control subjects.
|
17669634 |
2008 |
|
rs1049353
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Although the polymorphism 1359G/A was not associated with schizophrenia, the triplet repeat polymorphism of the CNR1 gene was significantly associated with schizophrenia, especially the hebephrenic subtype (P = 0.0028).
|
12082570 |
2002 |
|
rs12720071
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We previously reported that marijuana misuse in conjunction with specific cannabinoid receptor 1 (CNR1) genetic variants (rs12720071-G-allele carriers) contributed to white-matter (WM) brain volume deficits in schizophrenia patients.
|
22850347 |
2013 |
|
rs12720071
|
|
|
0.020 |
GeneticVariation |
BEFREE |
More interestingly, there were significant rs12720071 genotype-by-marijuana use interaction effects on WM volumes and neurocognitive impairment; suggestive of gene-environment interactions for conferring phenotypic abnormalities in schizophrenia.
|
21420833 |
2011 |
|
rs2023239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2023239 variant also was associated with significant improvements in positive and negative symptoms of schizophrenia.
|
26071625 |
2015 |
|
rs4707436
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we investigated three polymorphisms (rs1049353, rs806368, and rs4707436) in the cannabinoid type 1 receptor gene (CNR1) and weight gain in Korean patients with schizophrenia receiving olanzapine treatment.
|
21695734 |
2013 |
|
rs806368
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we investigated three polymorphisms (rs1049353, rs806368, and rs4707436) in the cannabinoid type 1 receptor gene (CNR1) and weight gain in Korean patients with schizophrenia receiving olanzapine treatment.
|
21695734 |
2013 |
|
rs9444584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Intriguingly, rs9444584 is in strong linkage disequilibrium with two other SNPs (rs9450898 (r(2) = 0.841) and rs2023239 (r(2) = 0.920)) that have been associated with addiction, obesity (rs2023239), and reduced fronto-temporal white matter volumes in schizophrenia patients as a result of cannabis misuse (rs9450898).
|
22362764 |
2012 |