|
rs2391191
|
|
|
0.090 |
GeneticVariation |
BEFREE |
On the one hand, the SNP rs2391191 corresponding to the R30K substitution in pLG72 was genetically linked to schizophrenia, reduced thickness of the brain cortex in schizophrenia-affected individuals, and altered memory function.
|
29417050 |
2018 |
|
rs2391191
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The stage-1 study showed association of the DAOA and PSEN2 genes with schizophrenia in a small sample; the stage-2 study with an expanded sample confirmed the disease association for 2-SNP and 3-SNP haplotypes, and the cis-phase interactions between rs2391191 and some other SNPs in the DAOA gene.
|
23335491 |
2013 |
|
rs2391191
|
|
|
0.090 |
GeneticVariation |
BEFREE |
No significant effect was observed in healthy controls.The finding of our study that the Arg30Lys risk variant is associated with a distinct cortical thinning provides new evidence for the pathophysiological impact of DAOA in schizophrenia.
|
21508934 |
2011 |
|
rs2391191
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Marker rs1935062 may be specifically associated with BD, while marker rs2391191 may be associated with SZ but not with BD.
|
21443574 |
2011 |
|
rs2391191
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We also found nominal haplotypic association, including M15/rs2391191 and M19/rs778294 with schizophrenia.
|
19237267 |
2009 |
|
rs2391191
|
|
|
0.090 |
GeneticVariation |
BEFREE |
For each gene, we genotyped 213 cases and 197 controls for SNPs previously associated with schizophrenia: rs2111902 (MDAAO-4), rs3918346 (MDAAO-5), rs3741775 (MDAAO-6) and rs3918347 (MDAAO-7) in DAO and rs746187 (M7), rs3916966 (M13), rs2391191 (M15) and rs3916972 (M25) in G72.
|
18165970 |
2008 |
|
rs2391191
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In order to evaluate the potential association of these two genes with schizophrenia in a Taiwanese sample, three single nucleotide polymorphisms (SNPs) for DAAO (rs2111902, rs3918346, rs3741775) and eleven SNPs for G72 (rs3916965, rs3916966, rs3916967, rs2391191, rs3916968, rs947267, rs778294, rs3916970, rs3916971, rs778293, rs3918342) were genotyped by the MALDI-TOF mass spectrometry method in 218 families (864 individuals) containing at least two siblings affected with schizophrenia.
|
16842973 |
2006 |
|
rs2391191
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Significant associations of schizophrenia with the A allele of rs947267 (P=0.012) and haplotype A-A-G (rs2391191-rs947267-rs778294) (P=0.008) were found in early-onset schizophrenic patients.
|
17179866 |
2006 |
|
rs2391191
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In this work, we have identified statistically significant differences in allele distributions of two markers rs3916965 (P = 0.019) and rs2391191 (P = 0.0010), and a highly significant association between haplotype AGAC of the G72/G30 locus (P = 1.7 x 10(-4)) and schizophrenia.
|
15194506 |
2004 |
|
rs947267
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Of 15 single nucleotide polymorphisms (SNPs) analyzed in the 95-kb G72/G30 gene region, M18/rs947267 and M22/rs778293 showed association with SCZ in Asians, and M24/rs1421292 with SCZ in Europeans.
|
18023149 |
2008 |
|
rs947267
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The rs778294 SNP, taken singly, had not been found to be associated with schizophrenia in previous studies, and the second SNP, rs947267, showed an opposite direction of genetic effect on schizophrenia risk here than in a previous study.
|
17651942 |
2007 |
|
rs947267
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our findings showed that the SNP rs947267 was significantly associated with schizophrenia in both case control and familial trio samples (A>C, chi(2)=8.36, p=0.004; Z=2.335, p=0.019), as well as with specific haplotypes, in particular those formed by the A allele of rs947267.
|
17293043 |
2007 |
|
rs947267
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In order to evaluate the potential association of these two genes with schizophrenia in a Taiwanese sample, three single nucleotide polymorphisms (SNPs) for DAAO (rs2111902, rs3918346, rs3741775) and eleven SNPs for G72 (rs3916965, rs3916966, rs3916967, rs2391191, rs3916968, rs947267, rs778294, rs3916970, rs3916971, rs778293, rs3918342) were genotyped by the MALDI-TOF mass spectrometry method in 218 families (864 individuals) containing at least two siblings affected with schizophrenia.
|
16842973 |
2006 |
|
rs947267
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Significant associations of schizophrenia with the A allele of rs947267 (P=0.012) and haplotype A-A-G (rs2391191-rs947267-rs778294) (P=0.008) were found in early-onset schizophrenic patients.
|
17179866 |
2006 |
|
rs947267
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Transmission disequilibrium analysis revealed a significant association between the G72/G30 rs947267 polymorphism and schizophrenia (P=0.016), with the A allele more commonly transmitted to patients.
|
16791105 |
2006 |
|
rs778294
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We also found nominal haplotypic association, including M15/rs2391191 and M19/rs778294 with schizophrenia.
|
19237267 |
2009 |
|
rs778294
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The rs778294 SNP, taken singly, had not been found to be associated with schizophrenia in previous studies, and the second SNP, rs947267, showed an opposite direction of genetic effect on schizophrenia risk here than in a previous study.
|
17651942 |
2007 |
|
rs778294
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In order to evaluate the potential association of these two genes with schizophrenia in a Taiwanese sample, three single nucleotide polymorphisms (SNPs) for DAAO (rs2111902, rs3918346, rs3741775) and eleven SNPs for G72 (rs3916965, rs3916966, rs3916967, rs2391191, rs3916968, rs947267, rs778294, rs3916970, rs3916971, rs778293, rs3918342) were genotyped by the MALDI-TOF mass spectrometry method in 218 families (864 individuals) containing at least two siblings affected with schizophrenia.
|
16842973 |
2006 |
|
rs778294
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Significant associations of schizophrenia with the A allele of rs947267 (P=0.012) and haplotype A-A-G (rs2391191-rs947267-rs778294) (P=0.008) were found in early-onset schizophrenic patients.
|
17179866 |
2006 |
|
rs7139958
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In two recent studies of our group, rs10042486, a single-nucleotide polymorphism (SNP) within 5HTR1A, and rs7139958, a SNP within the d-amino acid oxidase activator (DAOA) were found to be associated with clinical improvement, as detected by the positive symptom subscale of the Positive and Negative Symptoms Scale (PANSS) in a sample 221 Korean schizophrenia patients treated with various antipsychotics.
|
23495896 |
2013 |
|
rs7139958
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggested that rs7139958 and rs9558571 SNPs may be associated with more severe baseline positive symptoms in patients with schizophrenia.
|
22122005 |
2011 |
|
rs1935062
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Marker rs1935062 may be specifically associated with BD, while marker rs2391191 may be associated with SZ but not with BD.
|
21443574 |
2011 |
|
rs9558571
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggested that rs7139958 and rs9558571 SNPs may be associated with more severe baseline positive symptoms in patients with schizophrenia.
|
22122005 |
2011 |
|
rs3916967
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In order to evaluate the potential association of these two genes with schizophrenia in a Taiwanese sample, three single nucleotide polymorphisms (SNPs) for DAAO (rs2111902, rs3918346, rs3741775) and eleven SNPs for G72 (rs3916965, rs3916966, rs3916967, rs2391191, rs3916968, rs947267, rs778294, rs3916970, rs3916971, rs778293, rs3918342) were genotyped by the MALDI-TOF mass spectrometry method in 218 families (864 individuals) containing at least two siblings affected with schizophrenia.
|
16842973 |
2006 |
|
rs3916968
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In order to evaluate the potential association of these two genes with schizophrenia in a Taiwanese sample, three single nucleotide polymorphisms (SNPs) for DAAO (rs2111902, rs3918346, rs3741775) and eleven SNPs for G72 (rs3916965, rs3916966, rs3916967, rs2391191, rs3916968, rs947267, rs778294, rs3916970, rs3916971, rs778293, rs3918342) were genotyped by the MALDI-TOF mass spectrometry method in 218 families (864 individuals) containing at least two siblings affected with schizophrenia.
|
16842973 |
2006 |