Gene: GRIN2B ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs117578877
rs117578877
GRIN2B
T 0.700 GeneticVariation GWASCAT Genome-wide association study of schizophrenia in Ashkenazi Jews. 26198764

2015
dbSNP: rs890
rs890
GRIN2B
0.020 GeneticVariation BEFREE In summary, our results indicate that the GRIN2B SNP rs890 might be associated with schizophrenia</span> in the Chinese Han population. 27453061

2016
dbSNP: rs890
rs890
GRIN2B
0.020 GeneticVariation BEFREE In the present study, GRIN2B rs890 showed significant associations with schizophrenia. 26257337

2015
dbSNP: rs748128078
rs748128078
GRIN2B
0.010 GeneticVariation BEFREE We analyzed several variants located in the GluN2B C terminus and found that three variants in patients with autism (S1415L) or schizophrenia (L1424F and S1452F) (S1413L, L1422F, and S1450F in rodents, respectively) displayed impaired binding to membrane-associated guanylate kinase (MAGUK) proteins. 28283559

2017
dbSNP: rs756790727
rs756790727
GRIN2B
0.010 GeneticVariation BEFREE We analyzed several variants located in the GluN2B C terminus and found that three variants in patients with autism (S1415L) or schizophrenia (L1424F and S1452F) (S1413L, L1422F, and S1450F in rodents, respectively) displayed impaired binding to membrane-associated guanylate kinase (MAGUK) proteins. 28283559

2017
dbSNP: rs879254129
rs879254129
GRIN2B
0.010 GeneticVariation BEFREE We analyzed several variants located in the GluN2B C terminus and found that three variants in patients with autism (S1415L) or schizophrenia (L1424F and S1452F) (S1413L, L1422F, and S1450F in rodents, respectively) displayed impaired binding to membrane-associated guanylate kinase (MAGUK) proteins. 28283559

2017
dbSNP: rs1806191
rs1806191
GRIN2B
0.010 GeneticVariation BEFREE In addition, rs890 and rs1806191 were found to form a haplotype associated with schizophrenia. 27453061

2016
dbSNP: rs749655702
rs749655702
GRIN2B
0.010 GeneticVariation BEFREE Although no statistically significant association between any single mutation and SCZ or ASD was found, one of its variant, K1292R, is found only in the patient group. 27616045

2016
dbSNP: rs10845851
rs10845851
GRIN2B
0.010 GeneticVariation BEFREE Three haplotypes, CGA (rs10845849-rs12319804-rs10845851), CC (rs12582848-rs7952915), and AAGAC (rs2041986-rs11055665-rs7314376-rs7297101-rs2098469), had significant differences between SZ and controls (χ2 = 4.324, 4.582, and 4.492; p = 0.037, 0.032, and 0.034, respectively). 26020650

2015
dbSNP: rs12319804
rs12319804
GRIN2B
0.010 GeneticVariation BEFREE Three haplotypes, CGA (rs10845849-rs12319804-rs10845851), CC (rs12582848-rs7952915), and AAGAC (rs2041986-rs11055665-rs7314376-rs7297101-rs2098469), had significant differences between SZ and controls (χ2 = 4.324, 4.582, and 4.492; p = 0.037, 0.032, and 0.034, respectively). 26020650

2015
dbSNP: rs12582848
rs12582848
GRIN2B
0.010 GeneticVariation BEFREE Three haplotypes, CGA (rs10845849-rs12319804-rs10845851), CC (rs12582848-rs7952915), and AAGAC (rs2041986-rs11055665-rs7314376-rs7297101-rs2098469), had significant differences between SZ and controls (χ2 = 4.324, 4.582, and 4.492; p = 0.037, 0.032, and 0.034, respectively). 26020650

2015
dbSNP: rs12820037
rs12820037
GRIN2B
0.010 GeneticVariation BEFREE In addition, three SNPs, rs2098469, rs12820037, and rs7298664, were significantly associated with cognition factors PANSS subscores in SZ (F = 16.799, 7.112, and 13.357; p = 0.000, 0.017, and 0.000, respectively). 26020650

2015
dbSNP: rs2098469
rs2098469
GRIN2B
0.010 GeneticVariation BEFREE In addition, three SNPs, rs2098469, rs12820037, and rs7298664, were significantly associated with cognition factors PANSS subscores in SZ (F = 16.799, 7.112, and 13.357; p = 0.000, 0.017, and 0.000, respectively). 26020650

2015
dbSNP: rs7298664
rs7298664
GRIN2B
0.010 GeneticVariation BEFREE After applying the Bonferroni correction, rs7298664 still had significant genotype associations with SZ (p = 1.71×10(-7)). 26020650

2015
dbSNP: rs7952915
rs7952915
GRIN2B
0.010 GeneticVariation BEFREE Three haplotypes, CGA (rs10845849-rs12319804-rs10845851), CC (rs12582848-rs7952915), and AAGAC (rs2041986-rs11055665-rs7314376-rs7297101-rs2098469), had significant differences between SZ and controls (χ2 = 4.324, 4.582, and 4.492; p = 0.037, 0.032, and 0.034, respectively). 26020650

2015
dbSNP: rs1805502
rs1805502
GRIN2B
0.010 GeneticVariation BEFREE In the postmortem brain, the NR2B rs1805502 (T5988C) C allele was associated with reduced expression of NR1 mRNA and protein in schizophrenia. 23070074

2013
dbSNP: rs220599
rs220599
GRIN2B
0.010 GeneticVariation BEFREE Three polymorphisms (GRIN2B rs220599, GRM3 rs2189814 and PRKCA rs8074995) were associated with episodic verbal memory in both control and patients with cognitive deficit, but not in cognitively spared patients or the pooled schizophrenia sample. 21281445

2011
dbSNP: rs7301328
rs7301328
GRIN2B
0.010 GeneticVariation BEFREE The association sample showed statistically significant excesses of homozygosity for the polymorphisms in the 3' region of the last exon in the patients with schizophrenia (P = 0.004) and higher frequency of the G allele of the 366C/G polymorphism (corrected P = 0.04) in the patients than in the controls. 11317224

2001
dbSNP: rs1806201
rs1806201
GRIN2B
0.010 GeneticVariation BEFREE The findings provided no evidence of an association between schizophrenia and the 2664C/T polymorphism of the NR2B subunit gene. 10910800

2000