Therefore, we genotyped four polymorphisms in genes encoding two immune system regulatory proteins (CTLA-4 rs231775 and CD28 rs3116496), interleukin-6 (IL6 rs1800795) and transforming growth factor-β (TGFB1 rs1800470) in 513 schizophrenia patients and 374 controls.
Our first time observations suggest a significant relationship between IL-6 rs1800795</span> and reduced hippocampal volume in antipsychotic-naïve schizophrenia.