Gene: NOS1 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs28607014
rs28607014
NOS1
C 0.700 GeneticVariation GWASCAT Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect. 30285260

2019
dbSNP: rs28607014
rs28607014
NOS1
C 0.700 GeneticVariation GWASCAT Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia. 28991256

2017
dbSNP: rs2293052
rs2293052
NOS1
G 0.700 GeneticVariation GWASCAT Genome-wide association study of schizophrenia in Ashkenazi Jews. 26198764

2015
dbSNP: rs6490121
rs6490121
NOS1
0.060 GeneticVariation BEFREE We selected three candidate nNOS polymorphisms (Ex1f-VNTR, rs6490121 and rs41279104), associated with schizophrenia and cognition in previous studies, and tested their association with the efficiency of sensorimotor gating in healthy human adults. 30096361

2018
dbSNP: rs6490121
rs6490121
NOS1
0.060 GeneticVariation BEFREE However, the association of rs2682826, rs3782206, rs499776, rs3782219, rs41279104, rs3782221, rs1879417, rs4767540, rs561712, and rs6490121 polymorphisms with schizophrenia remains inconclusive. 28795310

2017
dbSNP: rs6490121
rs6490121
NOS1
0.060 GeneticVariation BEFREE The schizophrenia implicated NOS1 variants rs6490121 influences visual sensory processing as measured by the P1 response, either as part of the gene's pleiotropic effects on multiple aspects of brain function, or because of a primary influence on sensory processing that mediates the effects already seen in higher cognitive processes. 21520349

2012
dbSNP: rs6490121
rs6490121
NOS1
0.060 GeneticVariation BEFREE A common polymorphism within the nitric oxide sythanse-1 (NOS1) gene (rs6490121), initially identified as risk variant for schizophrenia, has been associated with variation in working memory and IQ. 22227051

2012
dbSNP: rs6490121
rs6490121
NOS1
0.060 GeneticVariation BEFREE We tested for association between NOS1 rs6490121 and cognitive functions known to be impaired in schizophrenia (IQ, episodic memory, working memory, and attentional control) in an Irish sample. 19805695

2009
dbSNP: rs6490121
rs6490121
NOS1
0.060 GeneticVariation BEFREE We selected seven SNPs (rs41279104, rs3782221, rs3782219, rs561712, rs3782206, rs2682826, and rs6490121) in NOS1 that were positively associated with schizophrenia in previous studies. 19513863

2009
dbSNP: rs41279104
rs41279104
NOS1
0.030 GeneticVariation BEFREE Schizophrenia risk (A)-allele carriers of NOS1 ex1c-SNP rs41279104 displayed significantly lower baseline cortisol levels (p = 0.004). 31002875

2019
dbSNP: rs41279104
rs41279104
NOS1
0.030 GeneticVariation BEFREE We selected three candidate nNOS polymorphisms (Ex1f-VNTR, rs6490121 and rs41279104), associated with schizophrenia and cognition in previous studies, and tested their association with the efficiency of sensorimotor gating in healthy human adults. 30096361

2018
dbSNP: rs3782206
rs3782206
NOS1
0.030 GeneticVariation BEFREE Based on our analysis, the rs3782206 polymorphism showed a strongest association with schizophrenia in allelic OR 1.15 (95% CI [1.05-1.25]), homozygote OR 1.35 (95% CI [1.09-1.66]), dominant OR 1.16 (95% CI [1.04-1.29]), and recessive OR 1.29 (95% CI [1.05-1.58]) models in Asian population. 28795310

2017
dbSNP: rs3782206
rs3782206
NOS1
0.030 GeneticVariation BEFREE Simple effect analyses further showed that the schizophrenia risk allele (T) of rs3782206 was associated with poorer performance in five measures for the patients (1-back, P=0.025; BX, P=0.017; AY, P<0.001; ANT conflict effect (RT differences), P=0.005; Stroop conflict effect (RT differences), P=0.019) and three measures for the controls ( for the 2-back task, P=0.042; for the ANT conlict effect (RT differences), P=0.013; for the ANT conflict effect (RT ratios), P=0.028). 25490993

2015
dbSNP: rs41279104
rs41279104
NOS1
0.030 GeneticVariation BEFREE The NOS1 schizophrenia risk genotype rs41279104 AA/AG was associated with slower reaction time in the 2-back task, as well as with reduced right-hemispheric activation of the frontal cortex for VFT in patients only. 21281558

2011
dbSNP: rs3782206
rs3782206
NOS1
0.030 GeneticVariation BEFREE We identified SNP rs3782206 and several haplotypes derived from it as being significantly associated with schizophrenia and, specifically, in a paranoid subgroup. 18544180

2008
dbSNP: rs499776
rs499776
NOS1
0.010 GeneticVariation BEFREE Similarly, in Caucasian population, the rs499776 polymorphism attributes risk association in homozygote OR 0.70 (95% CI [0.50-0.98]), dominant OR 3.57 (95% CI [2.34-5.27]), and recessive models OR 0.68 (95% CI [0.50-0.93]) with schizophrenia. 28795310

2017
dbSNP: rs2682826
rs2682826
NOS1
0.010 GeneticVariation BEFREE We selected seven SNPs (rs41279104, rs3782221, rs3782219, rs561712, rs3782206, rs2682826, and rs6490121) in NOS1 that were positively associated with schizophrenia in previous studies. 19513863

2009