Genetic evidence exhibited that rs11154801 was significantly associated with schizophrenia risk in both the discovery sample (9394 cases and 12462 controls, P=0.046, OR=0.958, 95% CI=0.918-0.999) and the replication sample (3240 cases and 14786 controls, P=0.024, OR=0.949, 95% CI=0.870-0.990).
However, there was a genotypic difference in AHI1 expression for SNP rs9321501, which was strongly associated with schizophrenia in the original study.