Our results demonstrate a significant impact of a single point mutation NL2 R215H on brain functions, providing a novel animal model for the study of schizophrenia and neuropsychiatric disorders.
Our results demonstrate that <i>Nlgn2</i> R215H KI homozygous mice manifest several behavioral abnormalities similar to those found in psychiatric patients carrying <i>NLGN2</i> mutations, indicating that dysfunction of <i>NLGN2</i> contributes to the pathogenesis of certain psychiatric symptoms commonly present in various mental disorders, not limited to schizophrenia.