|
rs2619538
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To test this, we examined the impact on visual processing in 61 healthy children aged 10-12 years of a genetic variant in DTNBP1 (rs2619538) that was common to all schizophrenia associated haplotypes in an earlier UK-Irish study.
|
19631276 |
2010 |
|
rs2619538
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We have previously published evidence of association with a dysbindin risk haplotype derived from alleles C-A-T at SNPs P1655 (rs2619539), P1635 (rs3213207) and SNP66961 (rs2619538) in two independent schizophrenia (SZ) case-control samples.
|
18162312 |
2008 |
|
rs2619538
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A trend towards statistical association (P = 0.058) between schizophrenia and rs2619538 was found.
|
17290445 |
2007 |
|
rs2619538
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A single haplotype, which included rs2619538 and P1583, and one rare haplotype, composed of P1320 and P1757, were significantly associated with schizophrenia, but no previously reported haplotypes were associated.
|
16044171 |
2005 |
|
rs2619538
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Within the subset of bipolar I cases with predominantly psychotic episodes of mood disturbance (n = 133) we found nominally significant support for association at this haploptype (p < .042) and at SNP rs2619538 (p = .003), with a pattern of findings similar to that in our schizophrenia sample.
|
15820225 |
2005 |
|
rs9370822
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In summary, the present results provide preliminary support for dysbindin (DTNBP1) gene variation, particularly SNPs rs1997679 and rs9370822, to be associated with the clinical phenotype of psychotic depression suggesting a possible neurobiological mechanism for an intermediate trait on the continuum between affective disorders and schizophrenia.
|
20951386 |
2011 |
|
rs9370822
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These results suggest that DTNBP1 is a good candidate for schizophrenia risk and rs9370822 is either functionally important or in disequilibrium with a functional SNP, although our observations should be viewed with caution until they are independently replicated.
|
20615671 |
2010 |
|
rs9370822
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Recently we identified a DTNBP1 SNP (rs9370822) that is strongly associated with schizophrenia.
|
20615259 |
2010 |
|
rs1011313
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We examined the effect of polymorphisms of two candidate genes that mediate glutamatergic signaling, viz., dysbindin (rs1011313) and neuregulin (rs35753505), on brain morphometry in patients with schizophrenia (N=38) and healthy subjects (N=37) from South India.
|
25042954 |
2014 |
|
rs1011313
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Polymorphisms in RGS4, G72/G30, and PIP5K2A were neither associated with SZ-ND nor with SZ-D. SNP8NRG241930 showed association with the PANSS cognitive and hostility/excitability factors, rs1011313 with the negative factor and SDS total score, and rs10917670 in RGS4 was associated with the depression factor.
|
19937977 |
2010 |
|
rs1018381
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genetic variation in dysbindin 1 (DTNBP1) gene region tagged by SNP rs1018381 exhibits a linkage with cognitive deficits in patients with schizophrenia and healthy subjects.
|
19497374 |
2009 |
|
rs1018381
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Conventional case-control comparisons showed that genotypes of the markers P1578 (rs1018381) and P1583 (rs909706) were nominally associated with schizophrenia in EAs and in AAs, respectively.
|
19862852 |
2009 |
|
rs2619539
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The possible association between a single nucleotide polymorphism (SNP) of DTNBP1 (rs2619539: P1655), which is a risk-independent SNP for schizophrenia in Japanese populations, and memory and IQ was investigated in 70 schizophrenia patients and 165 healthy volunteers in a Japanese population.
|
19496996 |
2009 |
|
rs2619539
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We have previously published evidence of association with a dysbindin risk haplotype derived from alleles C-A-T at SNPs P1655 (rs2619539), P1635 (rs3213207) and SNP66961 (rs2619538) in two independent schizophrenia (SZ) case-control samples.
|
18162312 |
2008 |
|
rs1997679
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, the present results provide preliminary support for dysbindin (DTNBP1) gene variation, particularly SNPs rs1997679 and rs9370822, to be associated with the clinical phenotype of psychotic depression suggesting a possible neurobiological mechanism for an intermediate trait on the continuum between affective disorders and schizophrenia.
|
20951386 |
2011 |
|
rs2619528
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In line with our a priori hypothesis, one DTNBP1 polymorphism previously linked to schizophrenia (rs2619528) was found to be associated with changes in the NGA; however, the direction of this association directly contrasts with our previous findings in a healthy control sample.
|
20180862 |
2010 |
|
rs909706
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Conventional case-control comparisons showed that genotypes of the markers P1578 (rs1018381) and P1583 (rs909706) were nominally associated with schizophrenia in EAs and in AAs, respectively.
|
19862852 |
2009 |
|
rs16876759
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four variants have been selected (rs3213207; rs1011313; rs16876759; rs2619522) on the basis of previous findings of association with schizophrenia, bipolar disorder and antidepressant response.
|
18562100 |
2008 |
|
rs2619522
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four variants have been selected (rs3213207; rs1011313; rs16876759; rs2619522) on the basis of previous findings of association with schizophrenia, bipolar disorder and antidepressant response.
|
18562100 |
2008 |
|
rs3213207
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have previously published evidence of association with a dysbindin risk haplotype derived from alleles C-A-T at SNPs P1655 (rs2619539), P1635 (rs3213207) and SNP66961 (rs2619538) in two independent schizophrenia (SZ) case-control samples.
|
18162312 |
2008 |
|
rs760666
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three correlated markers (rs875462, rs760666, and rs7758659) at the 3' region of DTNBP1 showed evidence for association to SZ (p = 0.004), observed in both the EA (p = 0.031) and the African American (AA) subset (p = 0.045) with the same over-transmitted allele.
|
17476109 |
2007 |
|
rs7758659
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three correlated markers (rs875462, rs760666, and rs7758659) at the 3' region of DTNBP1 showed evidence for association to SZ (p = 0.004), observed in both the EA (p = 0.031) and the African American (AA) subset (p = 0.045) with the same over-transmitted allele.
|
17476109 |
2007 |