Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1052133
rs1052133
0.020 GeneticVariation BEFREE Association between the 8-oxoguanine DNA glycosylase gene Ser326Cys polymorphism and age-related cataract: a systematic review and meta-analysis. 28631182

2018

dbSNP: rs156697
rs156697
0.020 GeneticVariation BEFREE As a dehydroascorbate reductase, it could contribute to the maintenance of cellular redox balance and it is interesting to note that the GSTO2 N142D polymorphism has been associated with multiple diseases including Alzheimer's disease, Parkinson's disease, familial amyotrophic lateral sclerosis, chronic obstructive pulmonary disease, age-related cataract and breast cancer. 26993125

2016

dbSNP: rs25487
rs25487
0.020 GeneticVariation BEFREE Polymorphisms of DNA repair genes XPD (Lys751Gln) and XRCC1 (Arg399Gln), and the risk of age-related cataract: a meta-analysis. 25285569

2015

dbSNP: rs25487
rs25487
0.020 GeneticVariation BEFREE The association of XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms with age-related cataract susceptibility observed in our meta-analyses supports the view that XRCC1 and XPD may play important roles in susceptibility to age-related cataract. 25873778

2015

dbSNP: rs156697
rs156697
0.020 GeneticVariation BEFREE rs4925 (Ala140Asp) of glutathione S-transferase omega-1 and rs156697 (Asn142Asp) of glutathione S-transferase omega-2 polymorphisms in 100 patients with age-related cataract and 130 controls were assessed. 23927022

2014

dbSNP: rs1052133
rs1052133
0.020 GeneticVariation BEFREE Results suggest that the Cys/Cys genotype of the OGG1-Ser326Cys polymorphism may be associated with increased risk of age-related cataract. 22306120

2012

dbSNP: rs104894201
rs104894201
0.010 GeneticVariation BEFREE Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts. 31369034

2019

dbSNP: rs1136410
rs1136410
0.010 GeneticVariation BEFREE Associations of PARP-1 variant rs1136410 with PARP activities, oxidative DNA damage, and the risk of age-related cataract in a Chinese Han population: A two-stage case-control analysis. 27840165

2017

dbSNP: rs7278468
rs7278468
0.010 GeneticVariation BEFREE Polymorphism rs7278468 is associated with Age-related cataract through decreasing transcriptional activity of the CRYAA promoter. 26984531

2016

dbSNP: rs1052559
rs1052559
0.010 GeneticVariation BEFREE This meta-analysis aimed to determine the relationships between XRCC1 Arg399Gln (rs25487 G>A) and XPD Lys751Gln (rs1052559 A>C) polymorphisms and susceptibility to age-related cataract. 25873778

2015

dbSNP: rs13181
rs13181
0.010 GeneticVariation BEFREE The association of XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms with age-related cataract susceptibility observed in our meta-analyses supports the view that XRCC1 and XPD may play important roles in susceptibility to age-related cataract. 25873778

2015

dbSNP: rs759412116
rs759412116
0.010 GeneticVariation BEFREE The association of XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms with age-related cataract susceptibility observed in our meta-analyses supports the view that XRCC1 and XPD may play important roles in susceptibility to age-related cataract. 25873778

2015

dbSNP: rs4925
rs4925
0.010 GeneticVariation BEFREE rs4925 (Ala140Asp) of glutathione S-transferase omega-1 and rs156697 (Asn142Asp) of glutathione S-transferase omega-2 polymorphisms in 100 patients with age-related cataract and 130 controls were assessed. 23927022

2014

dbSNP: rs79121622
rs79121622
0.010 GeneticVariation BEFREE HSF4 mutation p.Arg116His found in age-related cataracts and in normal populations produces childhood lamellar cataract in transgenic mice. 24975927

2014

dbSNP: rs3754334
rs3754334
0.010 GeneticVariation BEFREE Polymorphism, rs3754334, might be a variant on the EPHA2 gene that is commonly associated with the risk for age-related cataract in different ethnical and geographical populations. 23976972

2013

dbSNP: rs1190613858
rs1190613858
0.010 GeneticVariation BEFREE The purpose of this study was to investigate a possible association of the C1824T mutation with age-related cataract. 22079058

2012

dbSNP: rs58596362
rs58596362
0.010 GeneticVariation BEFREE The purpose of this study was to investigate a possible association of the C1824T mutation with age-related cataract. 22079058

2012

dbSNP: rs1346044
rs1346044
WRN
0.010 GeneticVariation BEFREE The aim of the study was to investigate the incidence of the C1367T (rs1346044) polymorphism in patients with age-related cataract. 20808731

2010