|
rs334
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The single point mutation (Glu6Val) promotes polymerization of hemoglobin S (HbS) and causes sickling of erythrocytes.
|
27636225 |
2016 |
|
rs334
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Meanwhile, individuals with the hHbS rs334 TT, IL10 rs3024500 AA, and IL17RD rs6780995 GA genotypes were more susceptible to severe malarial anaemia, cerebral malaria, and hyperpyrexia respectively.
|
24312262 |
2013 |
|
rs334
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The objective was to investigate whether haptoglobin (Hp) haplotypes constructed from the functional polymorphism (Hp1/Hp2) plus the functional promoter SNPs -61A-C (rs5471) and -101C-G (rs5470), or sickle cell trait (HbAS, rs334) were associated with risk of active trachoma when stratified by age and sex, in rural Gambian children.
|
20552021 |
2010 |
|
rs1206396500
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The single point mutation (Glu6Val) promotes polymerization of hemoglobin S (HbS) and causes sickling of erythrocytes.
|
27636225 |
2016 |
|
rs763767332
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The single point mutation (Glu6Val) promotes polymerization of hemoglobin S (HbS) and causes sickling of erythrocytes.
|
27636225 |
2016 |
|
rs1427407
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current study was conducted on 240 patients with SCD and 60 with sickle cell trait, to determine the association of genetic variants at the BCL11A (rs1427407) and HBS1-MYB (rs6934903) loci with fetal hemoglobin levels (HbF).
|
25457385 |
2015 |
|
rs321198
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals with sickle cell trait had significantly lower antibody levels to all blood-stage antigens, and recessive homozygotes for CD36 (rs321198) had significantly lower anti-malarial antibody levels to MSP2.
|
26314886 |
2015 |
|
rs6934903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current study was conducted on 240 patients with SCD and 60 with sickle cell trait, to determine the association of genetic variants at the BCL11A (rs1427407) and HBS1-MYB (rs6934903) loci with fetal hemoglobin levels (HbF).
|
25457385 |
2015 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recurrent cerebral venous thrombosis associated with heterozygote methylenetetrahydrofolate reductase C677T mutation and sickle cell trait without homocysteinemia: an autopsy case report and review of literature.
|
25074331 |
2014 |
|
rs6780995
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, individuals with the hHbS rs334 TT, IL10 rs3024500 AA, and IL17RD rs6780995 GA genotypes were more susceptible to severe malarial anaemia, cerebral malaria, and hyperpyrexia respectively.
|
24312262 |
2013 |
|
rs708567
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, IL17RE rs708567 GA and hHbS rs334 AT individuals were associated with protection from uncomplicated malaria and anaemia respectively in this study.
|
24312262 |
2013 |
|
rs5470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The objective was to investigate whether haptoglobin (Hp) haplotypes constructed from the functional polymorphism (Hp1/Hp2) plus the functional promoter SNPs -61A-C (rs5471) and -101C-G (rs5470), or sickle cell trait (HbAS, rs334) were associated with risk of active trachoma when stratified by age and sex, in rural Gambian children.
|
20552021 |
2010 |
|
rs5471
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The objective was to investigate whether haptoglobin (Hp) haplotypes constructed from the functional polymorphism (Hp1/Hp2) plus the functional promoter SNPs -61A-C (rs5471) and -101C-G (rs5470), or sickle cell trait (HbAS, rs334) were associated with risk of active trachoma when stratified by age and sex, in rural Gambian children.
|
20552021 |
2010 |
|
rs5030868
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Screening the full G6PD gene revealed the presence of the Mediterranean G6PD mutation (S188F) in our HBS patients (47.9%) and in controls (16.7%), and this difference was statistically significant (p = 0.0017).
|
19594365 |
2009 |
|
rs1335354324
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, clinical protocols for factor V (Leiden) 1691G>A, prothrombin 20210G>A, methylenetetrahydrofolate reductase (MTHFR) 1298A>C, hemochromatosis (HFE) 187C>G, and beta-globin (hemoglobin S) 17A>T were developed.
|
15229148 |
2004 |
|
rs397507444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, clinical protocols for factor V (Leiden) 1691G>A, prothrombin 20210G>A, methylenetetrahydrofolate reductase (MTHFR) 1298A>C, hemochromatosis (HFE) 187C>G, and beta-globin (hemoglobin S) 17A>T were developed.
|
15229148 |
2004 |
|
rs751377893
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, clinical protocols for factor V (Leiden) 1691G>A, prothrombin 20210G>A, methylenetetrahydrofolate reductase (MTHFR) 1298A>C, hemochromatosis (HFE) 187C>G, and beta-globin (hemoglobin S) 17A>T were developed.
|
15229148 |
2004 |
|
rs899127658
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, clinical protocols for factor V (Leiden) 1691G>A, prothrombin 20210G>A, methylenetetrahydrofolate reductase (MTHFR) 1298A>C, hemochromatosis (HFE) 187C>G, and beta-globin (hemoglobin S) 17A>T were developed.
|
15229148 |
2004 |