|
rs2066845
|
|
|
0.730 |
GeneticVariation |
BEFREE |
A case-control study of NOD2 polymorphisms known to be associated with Crohn's disease (CD) (Pro(268)Ser, Arg(702)Trp, Gly(908)Arg, and Leu(1007)fsinsC) was performed in 229 cases of primary AS with no diagnosed inflammatory bowel disease (IBD), 197 cases of AS associated with IBD (referred to as colitic spondylarthritis; comprising 78 with CD and 119 with ulcerative colitis [UC]), and 229 ethnically matched, healthy controls.
|
12115195 |
2002 |
|
rs2066845
|
|
|
0.730 |
GeneticVariation |
BEFREE |
NOD2 allelic frequencies in controls (3020insC, 0.009; 2722G>C, 0.009; 2104C>T, 0.042) did not significantly differ from patients with AS (3020insC, 0.009; 2722G>C, 0.004; 2104C>T, 0.031).
|
12508397 |
2003 |
|
rs2066844
|
|
|
0.010 |
GeneticVariation |
BEFREE |
NOD2 allelic frequencies in controls (3020insC, 0.009; 2722G>C, 0.009; 2104C>T, 0.042) did not significantly differ from patients with AS (3020insC, 0.009; 2722G>C, 0.004; 2104C>T, 0.031).
|
12508397 |
2003 |
|
rs2066845
|
|
|
0.730 |
GeneticVariation |
BEFREE |
We conclude that the insertion 3020insC mutation and the G2722C missense mutation in the CARD15 gene are not involved in the susceptibility to AS.
|
12595906 |
2003 |
|
rs4986790
|
|
|
0.760 |
GeneticVariation |
BEFREE |
There is no evidence for involvement of the CD14 C-260T or TLR4 A896G polymorphisms in susceptibility to AS.
|
15647432 |
2005 |
|
rs26307
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Results of haplotype analyses indicated that, after Bonferroni correction, the haplotype combination of rs26307 [C] and rs27356 [C] is significantly associated with AS in men (recessive/dominant model; P = 0.004), and the haplotype combination of rs28006 [C] and rs25957 [C] is significantly associated with AS in women (recessive/dominant model; P = 0.004).
|
15899038 |
2005 |
|
rs27356
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Results of haplotype analyses indicated that, after Bonferroni correction, the haplotype combination of rs26307 [C] and rs27356 [C] is significantly associated with AS in men (recessive/dominant model; P = 0.004), and the haplotype combination of rs28006 [C] and rs25957 [C] is significantly associated with AS in women (recessive/dominant model; P = 0.004).
|
15899038 |
2005 |
|
rs25957
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results of haplotype analyses indicated that, after Bonferroni correction, the haplotype combination of rs26307 [C] and rs27356 [C] is significantly associated with AS in men (recessive/dominant model; P = 0.004), and the haplotype combination of rs28006 [C] and rs25957 [C] is significantly associated with AS in women (recessive/dominant model; P = 0.004).
|
15899038 |
2005 |
|
rs28006
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results of haplotype analyses indicated that, after Bonferroni correction, the haplotype combination of rs26307 [C] and rs27356 [C] is significantly associated with AS in men (recessive/dominant model; P = 0.004), and the haplotype combination of rs28006 [C] and rs25957 [C] is significantly associated with AS in women (recessive/dominant model; P = 0.004).
|
15899038 |
2005 |
|
rs4986790
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms do not contribute to disease susceptibility in either AS or ReA.
|
16567359 |
2006 |
|
rs4986791
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms do not contribute to disease susceptibility in either AS or ReA.
|
16567359 |
2006 |
|
rs4986790
|
|
|
0.760 |
GeneticVariation |
BEFREE |
No significant difference between the frequencies of the Asp299Gly genotype or the Thr399Ile genotype between patients with AS and healthy HLA-B27 controls was found.
|
16837493 |
2006 |
|
rs4986791
|
|
|
0.040 |
GeneticVariation |
BEFREE |
No significant difference between the frequencies of the Asp299Gly genotype or the Thr399Ile genotype between patients with AS and healthy HLA-B27 controls was found.
|
16837493 |
2006 |
|
rs4986790
|
|
|
0.760 |
GeneticVariation |
BEFREE |
The minor allele frequency for the Asp299Gly variant (G) was significantly higher in AS cases compared to controls (7.5% vs 2.6%, respectively; OR 3.10, p = 0.037).
|
17143969 |
2007 |
|
rs1780329
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicate that the TNAP haplotype rs3767155 (G)/rs3738099 (G)/rs1780329 (T) is a novel genetic marker in men that is significantly associated with AS in multiplex families containing affected individuals of both sexes.
|
17195227 |
2007 |
|
rs3738099
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicate that the TNAP haplotype rs3767155 (G)/rs3738099 (G)/rs1780329 (T) is a novel genetic marker in men that is significantly associated with AS in multiplex families containing affected individuals of both sexes.
|
17195227 |
2007 |
|
rs3767155
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicate that the TNAP haplotype rs3767155 (G)/rs3738099 (G)/rs1780329 (T) is a novel genetic marker in men that is significantly associated with AS in multiplex families containing affected individuals of both sexes.
|
17195227 |
2007 |
|
rs1264457
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In particular, there was a markedly increased prevalence of heterozygosity at rs1264457 among B27-positive controls (74%, versus 47% in patients and 54% in random controls), suggesting a protective role of G128 in AS.
|
17665395 |
2007 |
|
rs11187265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic analysis showed that an exonic CYP26C1 SNP (rs11187265) is not associated with AS.
|
18050373 |
2007 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis.
|
18199597 |
2008 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The primary SNP of interest in a previous study of inflammatory bowel disease (IBD) (Arg381Gln; rs11209026) was found to be protective against AS in the Newfoundland population (P=0.04) and in the Toronto population (P=0.04) in single-marker univariate analysis.
|
18383363 |
2008 |
|
rs1024446168
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Pairwise analysis of the MMP-3/TIMP-1 alleles showed that 6A/C (OR = 3.23, 95% CI 1.50 to 6.95) and 6A/T (OR = 2.55, 95% CI 1.17 to 5.54) had a significantly greater risk of AS than the 5A/T alleles.
|
19019896 |
2009 |
|
rs142481975
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Pairwise analysis of the MMP-3/TIMP-1 alleles showed that 6A/C (OR = 3.23, 95% CI 1.50 to 6.95) and 6A/T (OR = 2.55, 95% CI 1.17 to 5.54) had a significantly greater risk of AS than the 5A/T alleles.
|
19019896 |
2009 |
|
rs4898
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To evaluate the effects of the MMP-3 -1171 and TIMP-1 372 T>C polymorphisms on the modified risk of AS.
|
19019896 |
2009 |
|
rs30187
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A specific ERAP1 haplotype, rs27044/10050860/30187-CCT, was strongly associated with increased risk of AS in all 3 case-control cohorts (pooled odds ratio [OR] 1.81, 95% confidence interval [95% CI] 1.46-2.24; P=7x10(-8)), while a second specific ERAP1 haplotype, rs30187/26618/26653-CTG, reduced the disease risk (pooled OR 0.77, 95% CI 0.67-0.88; P=9x10(-5)).
|
19404951 |
2009 |