|
rs1001007
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
rs10019009
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, the SNP rs10019009 was associated with AS in both the discovery cohort (P = 0.0012) and validation cohort (P = 0.0349), as well as overall (P = 0.0004) in genetic case-control association analysis.
|
26960368 |
2016 |
|
rs1004189
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed significant increase in the carriage of the T allele of rs11805303 and the A allele of rs1004189 in the AS group compared with the controls.
|
19522770 |
2009 |
|
rs1004234
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
rs10045403
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci.
|
23749187 |
2013 |
|
rs1004819
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study found no evidence for an association between either of the two previously identified AS-susceptibility IL-23R SNPs (rs1004819 and rs10889677) and onset of AS, indicating a possible difference in pathogenesis of AS between Chinese and European patients.
|
23767933 |
2013 |
|
rs1004819
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that only rs1004819 has a significant association with AS, and that the remaining four SNP alleles are not associated with AS.
|
24998354 |
2014 |
|
rs10050860
|
|
|
0.790 |
GeneticVariation |
BEFREE |
We revealed 16 AS-associated variants with nominal evidence in Han Chinese, including rs10865331 (P=6.30×10-10), rs10050860 (P=4.09×10-5) and rs8070463 (P=1.03×10-4).
|
31523044 |
2019 |
|
rs10050860
|
|
|
0.790 |
GeneticVariation |
BEFREE |
To characterize the alterations, as well as their mechanisms, induced in the HLA-B27-bound peptidome expressed in live cells by the natural ERAP1 polymorphisms predisposing to ankylosing spondylitis (AS): R528K and N575D/Q725R.
|
25469497 |
2015 |
|
rs10050860
|
|
|
0.790 |
GeneticVariation |
GWASDB |
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
|
21743469 |
2011 |
|
rs10050860
|
|
|
0.790 |
GeneticVariation |
BEFREE |
The minor allele frequencies of rs10050860 (p = 0.006) and rs2287987 (p = 0.002) showed a significant decrease in AS patients compared to controls.
|
20032103 |
2010 |
|
rs10050860
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Except in rs27434 (P = 0.23), the significant correlation between ERAP1 polymorphisms and AS susceptibility has been detected in rs27044 (OR 1.57, P < 0.001), rs17482078 (OR 1.271, P < 0.001), rs10050860 (OR 0.772, P = 0.006), rs30187 (OR 1.348, P < 0.001), rs2287987 (OR 0.746, P < 0.001) and rs27037 (OR 1.257, P = 0.001).
|
21229357 |
2012 |
|
rs10050860
|
|
|
0.790 |
GeneticVariation |
BEFREE |
The rs17482078/rs10050860/rs30187-CCT haplotype was significantly associated with increased risk of SpA in both cohorts (P(combined)= 9.08×10(-4)), including AS and non-AS (P(combined)=6.16×10(-4) and P(combined)=0.049, respectively), whereas the -TTC haplotype was associated with reduced risk of SpA, including AS and non-AS (P(combined)=2.36×10(-7), P(combined)= 5.69×10(-6) and P(combined)= 2.13×10(-4), respectively).
|
22896742 |
2013 |
|
rs10050860
|
|
|
0.790 |
GeneticVariation |
BEFREE |
But 5 SNPs (rs17482078, rs2287987, rs27044, rs26653, and rs10050860) did not show statistical association with the risk of AS in Asians.
|
25401226 |
2015 |
|
rs10050860
|
|
|
0.790 |
GeneticVariation |
BEFREE |
This meta-analysis shows that the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 are associated with the development of AS in Europeans.
|
21877190 |
2011 |
|
rs10050860
|
|
|
0.790 |
GeneticVariation |
BEFREE |
All patients and controls were Korean.872 patients with AS fulfilling the modified New York criteria and 403 healthy controls were genotyped for five single nucleotide polymorphisms (SNPs), rs27044, rs17482078, rs10050860, rs30107 and rs2287987, known to be associated with AS in Caucasians.
|
19414429 |
2010 |
|
rs10050860
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Moreover, the T allele and TT genotype of rs10050860 polymorphism were associated with increased risk of the disease in both all and HLA-B27 positive AS group.
|
30412714 |
2018 |
|
rs10065172
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among two tag SNPs of IRGM, no correlation was observed between rs10065172 and AS susceptibility.
|
28031552 |
2017 |
|
rs10094579
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
rs1009759
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, we did not find any evidence of genetic association between PD-L2 rs1009759/rs6476985 polymorphisms and AS (p=0.371 and 0.061, respectively).
|
21269571 |
2011 |
|
rs1013210
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis.
|
30946743 |
2019 |
|
rs10204525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that SNPs rs2227982 and rs10204525 were interrelated to AAU; the influence on AAU could be related with gender, HLA-B27, and AS stat</span>us.
|
30540488 |
2019 |
|
rs10208769
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratified by gender, another two SNPs (rs11428092 and rs10208769 in USP34) were associated with AS in males but not females, though this was not statistically significant after Bonferroni correction.
|
28493913 |
2017 |
|
rs1024446168
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Pairwise analysis of the MMP-3/TIMP-1 alleles showed that 6A/C (OR = 3.23, 95% CI 1.50 to 6.95) and 6A/T (OR = 2.55, 95% CI 1.17 to 5.54) had a significantly greater risk of AS than the 5A/T alleles.
|
19019896 |
2009 |
|
rs10280089
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis.
|
30946743 |
2019 |