|
rs397514465
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Ten studies described MTHFR C677T (108 with TT genotype and 2018 with CC genotype) -homocysteine relationship and six studies (735 stroke cases and 713 controls) described homocysteine-ischemic stroke relationship.
|
23505425 |
2013 |
|
rs702553
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Previous research has shown the single nucleotide polymorphism (rs702553) on the PDE4D gene to be associated with stroke and carotid atherosclerosis.
|
23778321 |
2013 |
|
rs152312
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We selected and genotyped a PDE4D single nucleotide polymorphism (SNP 41, rs152312) as a candidate marker for susceptibility to ischemic stroke because SNP 41 has shown the most significant association with stroke in both a meta-analysis and the original Icelandic study of the PDE4D gene.
|
19399275 |
2009 |
|
rs2910829
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs (single nucleotide polymorphisms) (rs966221, rs456009 and rs2910829) in PDE4D were chosen based on the significant association with stroke reported previously in a Western population, and these were genotyped using PCR/RFLP (restriction-fragment-length polymorphism) and confirmed by sequencing.
|
18694398 |
2009 |
|
rs456009
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs (single nucleotide polymorphisms) (rs966221, rs456009 and rs2910829) in PDE4D were chosen based on the significant association with stroke reported previously in a Western population, and these were genotyped using PCR/RFLP (restriction-fragment-length polymorphism) and confirmed by sequencing.
|
18694398 |
2009 |
|
rs966221
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that only SNP83 (rs966221) was associated with stroke.
|
18694398 |
2009 |
|
rs1186757238
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we performed a genetic association study on the single nucleotide polymorphisms (SNPs) present in the genes CD14 (-159 C/T), TNFalpha (-308 G/A), IL-1alpha (-889 C/T), IL-6 (-174 G/C), PSMA6 (-8 C/G), and PDE4D (SNP83 T/C, respectively) in order to discern their possible role in the susceptibility to stroke in a North Indian population.
|
18158110 |
2008 |
|
rs918592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of rs918592 with stroke was confined exclusively to current smokers (OR=3.2, P=0.00014), with no association observed among never-smokers (OR=0.9, P=0.75) or former smokers (OR=1.2, P=0.66), demonstrating a gene-environment interaction (P=0.03).
|
16835261 |
2006 |