| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.060 | GeneticVariation | BEFREE | Consistent with these results, in clopidogrel-treated patients in TRITON-TIMI 38, there was no association between Q192R and the rates of CV death, myocardial infarction, or stroke (RR 11.2 %, QR 8.6 %, and QQ 9.3 %; P = 0.66) or stent thrombosis (RR 2.4 %, QR 0.7 %, and QQ 1.6 %, P = 0.30), with patients with the putative at-risk Q variant having numerically lower event rates. | 26573179 | 2016 |
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0.060 | GeneticVariation | BEFREE | The presence of the R allele of the Q192R PON1 polymorphism seems to potentiate this risk for stroke. | 24225313 | 2014 |
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0.060 | GeneticVariation | BEFREE | Therefore, the results of this meta-analysis indicate, the Q192R polymorphism could be an important risk factor for stroke, especially in the Caucasian population. | 20532959 | 2010 |
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0.060 | GeneticVariation | BEFREE | Lack of association between the paraoxonase 1 Q/R192 single nucleotide polymorphism and stroke in a Chinese cohort. | 19902814 | 2009 |
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|
0.060 | GeneticVariation | BEFREE | Paraoxonase 1 gene Q192R polymorphism affects stroke and myocardial infarction risk. | 16472799 | 2006 |
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0.060 | GeneticVariation | BEFREE | These results suggest that Gln192Arg genotype is an important risk factor for stroke. | 16239632 | 2005 |
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0.010 | GeneticVariation | BEFREE | The miR-SNP rs3735590 at the paraoxonase 1 (PON1) gene was finally selected and its associations with stroke and carotid IMT were evaluated. | 23497787 | 2013 |
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|
0.010 | GeneticVariation | BEFREE | The presence of rs705381 (-162) in the promoter region of PON1 was significantly associated with total stroke (P(adjusted) = 0.0007, OR = 0.57 [95% CI = 0.41-0.79]) and ischemic stroke (P(adjusted) = 0.0017, OR = 0.54 [95% CI = 0.37-0.79]) when analyzed using a dominant model, but was not associated with hemorrhagic stroke. | 23356507 | 2013 |
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0.010 | GeneticVariation | BEFREE | There was also a nominal association between rs854571 (-824) and total stroke. | 23356507 | 2013 |
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0.010 | GeneticVariation | BEFREE | A meta-analysis was therefore conducted by including the studies that examined the association between two common polymorphisms (L55M and Q192R) in the coding region of PON1 gene and the risk of stroke. | 20532959 | 2010 |