|
rs12284594
|
|
G |
0.700 |
GeneticVariation |
GWASDB |
The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.
|
21298047 |
2011 |
|
rs1799971
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.
|
26392368 |
2016 |
|
rs1799971
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The A118G polymorphism may also be associated with substance dependence and susceptibility to other disorders, including epilepsy and schizophrenia.
|
21919606 |
2011 |
|
rs1799971
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The Asn40Asp SNP in OPRM1 does not appear to affect risk for SD.
|
16387451 |
2006 |
|
rs1799971
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Controlling for demographic features and substance dependence diagnosis, analyses examined the allelic association of Asn40Asp with the five personality dimensions.
|
15167694 |
2004 |
|
rs1799971
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Eight single nucleotide polymorphisms (SNPs) at the OPRM1 locus, i.e., -2044C/A, -1793T/A, -1699insT, -1469T/C, -1320A/G, -111C/T, +17C/T (Ala6Val), and +118A/G (Asn40Asp) were genotyped in 676 subjects: 318 EA subjects and 124 AA subjects with substance dependence, and 179 EA normal controls, and 55 AA normal controls.
|
12815747 |
2003 |
|
rs1799971
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In both patient samples and by both methods we were unable to corroborate the hypothesis of OPRM1 A118G polymorphism as a particular risk factor for any kind of substance dependence including opioid addiction.
|
11424981 |
2001 |
|
rs17174638
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Four of the variants [-1793T/A, -1699insT, -1320A/G, and -111C/T] are in virtually complete linkage disequilibrium (LD) to compose a sequence pattern, which does not associate with any of the seven categories of substance dependence.
|
12815747 |
2003 |
|
rs17174638
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Common to this category was a characteristic pattern of sequence variants [-1793T-->A, -1699Tins, -1320A-->G, -111C-->T, +17C-->T (A6V)], which was associated with substance dependence.
|
11092766 |
2000 |
|
rs1868152
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated, in a Spanish sample of 1711 subjects with substance dependence (1011 of them cocaine dependent) and 1719 control individuals, three SNPs identified as GWS in previous studies: rs1868152 and rs2952621 (located near LINC02052 and LINC01854, respectively), associated with substance dependence, and rs2629540 (in the first intron of FAM53B), associated with cocaine dependence.
|
29715653 |
2018 |
|
rs2629540
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated, in a Spanish sample of 1711 subjects with substance dependence (1011 of them cocaine dependent) and 1719 control individuals, three SNPs identified as GWS in previous studies: rs1868152 and rs2952621 (located near LINC02052 and LINC01854, respectively), associated with substance dependence, and rs2629540 (in the first intron of FAM53B), associated with cocaine dependence.
|
29715653 |
2018 |
|
rs2952621
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2952621 variant, located downstream from the yet uncharacterized gene LINC01854, is associated with substance dependence in our Spanish sample.
|
29715653 |
2018 |
|
rs2281285
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We previously demonstrated that prodynorphin (PDYN) haplotypes and single nucleotide polymorphism (SNP) rs2281285 are associated with alcohol dependence and the propensity to drink in negative emotional states, and recent studies suggest that PDYN gene effects on substance dependence risk may be sex-related.
|
26502829 |
2015 |
|
rs13273442
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although these data are modestly powered for other substances, our results provide no evidence that correlates of rs13273442 represent a general substance dependence liability.
|
24401102 |
2014 |
|
rs10654394
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The common variant, rs10654394, was not associated with BMI and neither common variant was associated with SD in either population.
|
23028917 |
2012 |
|
rs1799972
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Previous studies of the association of the C17T polymorphism of the mu opiate receptor gene with substance dependence compared cases with substance dependence to controls and usually found no significant association.
|
21070507 |
2012 |
|
rs1229984
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Different studies have produced inconclusive results regarding association between rs1229984 (or rs2066702) and substance dependence.
|
21497796 |
2011 |
|
rs165774
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of both rs4680 and rs165774 with substance dependence, a common comorbidity of schizophrenia has not been investigated.
|
22208661 |
2011 |
|
rs2066702
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Different studies have produced inconclusive results regarding association between rs1229984 (or rs2066702) and substance dependence.
|
21497796 |
2011 |
|
rs4680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of both rs4680 and rs165774 with substance dependence, a common comorbidity of schizophrenia has not been investigated.
|
22208661 |
2011 |
|
rs1042114
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Nominally significant associations (P<0.05) of five SNPs with SD were observed; only the association of the non-synonymous variant G80T with OD remained significant after correction for multiple testing using SNPSpD.
|
17622222 |
2008 |
|
rs1051660
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In humans, the 36G > T single nucleotide polymorphism (SNP) on KOR gene, that was recently identified, has been found associate with substance dependence, with inconclusive findings.
|
17373729 |
2007 |
|
rs6454674
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In EAs, risk for each SD subtype significantly increased with the number of "G" alleles at rs6454674 (single nucleotide polymorphisms [SNP]3).
|
17509535 |
2007 |
|
rs2023239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the association of 4 SNPs (rs6928499, rs806379, rs1535255, rs2023239) in the distal region of intron 2 of CNR1 both with individual substance dependence diagnoses (i.e., alcohol, cocaine, and opioids), as well as with polysubstance dependence.
|
16741937 |
2006 |
|
rs324420
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although a link between the FAAH P129T variant and human drug abuse has been reported, the extent of risk and specific types of substance addiction vulnerability remain to be determined.
|
16972078 |
2006 |