Gene: RET ×
Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs74799832
rs74799832
RET
0.720 GeneticVariation BEFREE In the present study, we investigated whether the oncogenic RET mutants RET2A (C634R) and RET2B (M918T) were regulated by LRIG1, and the possible effects of LRIG1 expression in thyroid cancer were investigated in three different clinical cohorts and in a RET2B-driven mouse model of MTC. 29436694

2018
dbSNP: rs74799832
rs74799832
RET
0.720 GeneticVariation BEFREE In present result, RET rs1799939, rs1800858 and rs74799832 polymorphisms might be the risk factors for TC. 26191299

2015
dbSNP: rs1799939
rs1799939
RET
0.020 GeneticVariation BEFREE In present result, RET rs1799939, rs1800858 and rs74799832 polymorphisms might be the risk factors for TC. 26191299

2015
dbSNP: rs1799939
rs1799939
RET
0.020 GeneticVariation BEFREE A G691S RET polymorphism was present with a higher frequency in radiation-induced epithelial thyroid tumours (55%) than in sporadic tumours (20%) and in control normal thyroid tissues (15%). 12085189

2002
dbSNP: rs75076352
rs75076352
RET
0.010 GeneticVariation BEFREE In the present study, we investigated whether the oncogenic RET mutants RET2A (C634R) and RET2B (M918T) were regulated by LRIG1, and the possible effects of LRIG1 expression in thyroid cancer were investigated in three different clinical cohorts and in a RET2B-driven mouse model of MTC. 29436694

2018
dbSNP: rs1800858
rs1800858
RET
0.010 GeneticVariation BEFREE In present result, RET rs1799939, rs1800858 and rs74799832 polymorphisms might be the risk factors for TC. 26191299

2015
dbSNP: rs75234356
rs75234356
RET
0.010 GeneticVariation BEFREE Nevertheless, an extensive molecular analysis that included all codons was prompted by the diagnosis of thyroid neoplasm in a patient's sister, and identified the rare intracellular RET p.Ser891Ala mutation. 23295303

2012
dbSNP: rs377767414
rs377767414
RET
0.010 GeneticVariation BEFREE If the germline RET R770Q variant has a causative role in the pathogenesis of the mixed medullar/follicular derived histology of the thyroid tumour in the index patient of family 1 has to be proven. 20013610

2010
dbSNP: rs377767427
rs377767427
RET
0.010 GeneticVariation BEFREE New mutations in the RET protooncogene-L881V - associated with medullary thyroid carcinoma and -R770Q - in a patient with mixed medullar/follicular thyroid tumour. 20013610

2010
dbSNP: rs79658334
rs79658334
RET
0.010 GeneticVariation BEFREE A rapid method for the purification of wild-type and V804M mutant ret catalytic domain: A tool to study thyroid cancer. 16490247

2006