|
rs13407215
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs1906252
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs191044310
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs11603305
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, SLC1A1 in our gene-based analysis and two TS GWAS SNPs showed nominal significance, rs11603305 (intergenic) and rs621942 (PICALM).
|
28555406 |
2018 |
|
rs621942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, SLC1A1 in our gene-based analysis and two TS GWAS SNPs showed nominal significance, rs11603305 (intergenic) and rs621942 (PICALM).
|
28555406 |
2018 |
|
rs72853320
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Conditional FDR analysis further revealed novel variants significantly associated with TS (p < 8 × 10<sup>-7</sup>) when conditioning on intracranial (rs2708146, q = 0.046; and rs72853320, q = 0.035) and hippocampal (rs1922786, q = 0.001) volumes, respectively.
|
30902966 |
2019 |
|
rs2228079
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found also that the minor all</span>ele G of rs2228079 was more frequent in GTS patients with depression as compared to the patients without depression (p = 0.015).
|
26317759 |
2015 |
|
rs5751876
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele T frequency of rs5751876 was lower in GTS patients with </span>co-morbid attention deficit hyperactivity disorder (p = 0.022), and TT+TC genotypes were less frequent in the non-OCD anxiety disorder group (p = 0.045).
|
26317759 |
2015 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our study supports the involvement of the BDNF Val66Met polymorphism as a common genetic susceptibility for OCD and TS in the Chinese Han population, showing specific gender trends.
|
25771937 |
2015 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The G196A polymorphism of the BNDF gene was genotyped in 88 GTS trios.
|
16541456 |
2006 |
|
rs759834365
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The G196A polymorphism of the BNDF gene was genotyped in 88 GTS trios.
|
16541456 |
2006 |
|
rs759834365
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our study supports the involvement of the BDNF Val66Met polymorphism as a common genetic susceptibility for OCD and TS in the Chinese Han population, showing specific gender trends.
|
25771937 |
2015 |
|
rs746682028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G196A polymorphism of the BNDF gene was genotyped in 88 GTS trios.
|
16541456 |
2006 |
|
rs9357271
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The frequency of MAFs of the genotyped SNPs was lower in GTS patients with Attention Deficit Hyperactivity Disorder (for rs9357271 and rs9296249, P=0.039 and rs4714156, P=0.040) and higher in GTS patients without comorbidities (for rs9357271 and rs9296249 P=0.021 and rs4714156 P=0.025).
|
24993631 |
2014 |
|
rs9357271
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We stratified our group of patients with TS according to presence or absence of obsessive-compulsive disorder and/or attention-deficit disorder and found that variants in BTBD9 were strongly associated with TS without obsessive-compulsive disorder (chi(2) = 12.95 [P < .001] for rs9357271).
|
19822783 |
2009 |
|
rs9357271
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Variants of the BTB/POZ domain-containing protein 9 gene (BTBD9) (rs4714156, rs9357271, and rs9296249) and the serotonin 5-HT-2C receptor gene (HTR2C) (rs518147 and rs3813929) were reported to be associated with Tourette syndrome (TS) in White population recently.
|
22914617 |
2012 |
|
rs9296249
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Variants of the BTBD9 gene (rs4714156, rs9296249 and rs9357271) have been reported to be associated with GTS in French Canadian and Chinese Han populations.
|
24993631 |
2014 |
|
rs9296249
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There was a statistically significant association between the variant rs9296249 of the BTBD9 gene and the TS phenotype.
|
22914617 |
2012 |
|
rs4714156
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequency of MAFs of the genotyped SNPs was lower in GTS patients with Attention Deficit Hyperactivity Disorder (for rs9357271 and rs9296249, P=0.039 and rs4714156, P=0.040) and higher in GTS patients without comorbidities (for rs9357271 and rs9296249 P=0.021 and rs4714156 P=0.025).
|
24993631 |
2014 |
|
rs2289664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
By examining clinical data, we found there were significant TD-related phenotype differences between those OCD probands with and without the N845S variant with regard to the co-occurrence of TD (Fisher's exact test P=0.014, OR=6.03).
|
23321619 |
2013 |
|
rs3793798
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, rs3793798 also indicated a positive association associated with TS (TDT, χ<sup>2 </sup>=<sup> </sup>5.025, P = 0.028; HRR, χ<sup>2 </sup>=<sup> </sup>0.250, P = 0.617).
|
28090804 |
2018 |
|
rs1049353
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Compared with the published CNR1 sequence, three single base substitutions were identified: 1326T --> A, 1359G --> A, 1419 + 1G --> C. The change at position 1359 is a common polymorphism (1359 G/A) without allelic association with TS.
|
15108190 |
2004 |
|
rs7868992
|
|
G |
0.810 |
GeneticVariation |
GWASCAT |
Genome-wide association study of Tourette's syndrome.
|
22889924 |
2013 |
|
rs7868992
|
|
G |
0.810 |
GeneticVariation |
GWASDB |
Genome-wide association study of Tourette's syndrome.
|
22889924 |
2013 |
|
rs7868992
|
|
|
0.810 |
GeneticVariation |
BEFREE |
PCR-directed sequencing was used to evaluate the genetic contributions of three SNPs in COL27A1(rs4979356, rs4979357 and rs7868992) using haplotype relative risk (HRR) and transmission disequilibrium tests (TDT) with a total of 260 Tourette syndrome trios.
|
26235311 |
2015 |