|
rs1800451
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In analyses stratified by ethnicity, rs7096206 (C/G: OR = 1.31, 95% CI: 1.10-1.57, <i>p</i> = 0.003; GG vs. GC + CC: OR = 0.69, 95% CI: 0.56-0.85, <i>p</i> < 0.001) and A/O (O/A: OR = 1.34, 95% CI: 1.10-1.64, <i>p</i> = 0.004) were associated with tuberculosis risk in Asians, A/O (AA vs. AO + OO: OR = 0.71, 95% CI: 0.51-0.99, <i>p</i> = 0.041) and rs1800451 (AC vs. AA + CC: OR = 2.70, 95% CI: 1.27-5.74, <i>p</i> = 0.010) were associated with tuberculosis risk in Americans, and rs1800451 (C/A: OR = 0.92, 95% CI: 0.86-0.99, <i>p</i> = 0.035) was associated with tuberculosis risk in Africans.
|
30393476 |
2018 |
|
rs1800451
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Many studies have investigated the association between MBL2 exon 1 polymorphisms (rs1800450, rs1800451, and rs5030737) and TB risk, but yielded inconclusive results.
|
30154670 |
2018 |
|
rs1800451
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In conclusion, MBL2 rs1800450 and rs1800451 polymorphisms play a protective role in TB infection and reinforce their critical significance as a potential genetic marker for TB resistance.
|
27876780 |
2016 |
|
rs1800451
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Assuming a recessive mode of inheritance, we found a protective association between TB and the MBL2 G57E variant (odds ratio 0.60, confidence interval 0.4-0.9, P 0.008) and the corresponding LYQC haplotype (P(corrected) 0.007) which applied, however, only to TB caused by M. africanum but not to TB caused by M. tuberculosis.
|
21695215 |
2011 |
|
rs1800451
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We found that (i) the prevalence of the common variant MBL alleles is correlated with the incidence of tuberculosis in sub-Saharan Africa (r=0.565), (ii) the mutant MBL G57E allele, in either the homozygous or compound heterozygous state, is associated with susceptibility to HIV-1 infection in the Gabonese population (P=0.019).Our data plus those in the literature suggest that individuals who are homozygous for the mutant MBL alleles display increased susceptibility to infections.
|
12847552 |
2003 |
|
rs7096206
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In analyses stratified by ethnicity, rs7096206 (C/G: OR = 1.31, 95% CI: 1.10-1.57, <i>p</i> = 0.003; GG vs. GC + CC: OR = 0.69, 95% CI: 0.56-0.85, <i>p</i> < 0.001) and A/O (O/A: OR = 1.34, 95% CI: 1.10-1.64, <i>p</i> = 0.004) were associated with tuberculosis risk in Asians, A/O (AA vs. AO + OO: OR = 0.71, 95% CI: 0.51-0.99, <i>p</i> = 0.041) and rs1800451 (AC vs. AA + CC: OR = 2.70, 95% CI: 1.27-5.74, <i>p</i> = 0.010) were associated with tuberculosis risk in Americans, and rs1800451 (C/A: OR = 0.92, 95% CI: 0.86-0.99, <i>p</i> = 0.035) was associated with tuberculosis risk in Africans.
|
30393476 |
2018 |
|
rs7096206
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Polymorphisms of MBL (rs7096206) and MASP-2 (rs2273346 and rs6695096) were associated with the susceptibility of TB, and there were gene-gene interactions among them.
|
25887173 |
2015 |
|
rs7096206
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Passive smoking, cooking with solid fuel, and polymorphisms of MBL (rs7096206) and MASP-2 (rs6695096) genes were associated with susceptibility to TB in non-smokers, and there were gene-environment interactions among them.
|
25312983 |
2014 |
|
rs1800450
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs1800450 (B/A: OR = 0.42, 95% CI: 0.25-0.72, <i>p</i> = 0.001) was associated with tuberculosis risk in Europeans.
|
30393476 |
2018 |
|
rs5030737
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Many studies have investigated the association between MBL2 exon 1 polymorphisms (rs1800450, rs1800451, and rs5030737) and TB risk, but yielded inconclusive results.
|
30154670 |
2018 |