|
rs6967330
|
|
|
0.040 |
GeneticVariation |
BEFREE |
GAC haplotype from rs4730125, rs6967330, and rs408223 was associated with pre-school current wheeze and school-age asthma.
|
31610042 |
2020 |
|
rs6967330
|
|
|
0.040 |
GeneticVariation |
BEFREE |
rs6967330;G>A was genotyped (n = 216), and CDHR3 mRNA expression was measured in peripheral blood leukocytes (n = 69) from a subgroup of children wheezing with RV infection acute and at a follow-up visit 2-3 months later, and in healthy controls.Standardized TaqMan assays were used.
|
29314338 |
2018 |
|
rs6967330
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Recent studies have demonstrated that a coding SNP (rs6967330, Cys529→Tyr) in cadherin-related family member 3 (CDHR3), which was previously associated with wheezing illness and hospitalizations in infancy, could support efficient human rhinovirus C (RV-C) entry and replication.
|
28318885 |
2017 |
|
rs6967330
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A coding single nucleotide polymorphism (rs6967330, C529Y) was previously linked to greater cell-surface expression of CDHR3 protein, and an increased risk of wheezing illnesses and hospitalizations for childhood asthma.
|
25848009 |
2015 |
|
rs7216389
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The rs7216389 polymorphism may be a predictor for identifying infants with predisposition to virus-induced wheezing to persistent asthma.
|
26782568 |
2015 |
|
rs7216389
|
|
|
0.030 |
GeneticVariation |
BEFREE |
There was significant interaction between rs7216389 and domestic furred pets, with a positive association between pets and wheeze among homozygous wild-type carriers and a negative association among homozygous variant allele carriers.
|
21796154 |
2012 |
|
rs7216389
|
|
|
0.030 |
GeneticVariation |
BEFREE |
rs7216389 was significantly associated with the development of wheeze (hazard ratio 1.64 [1.05-2.59], P value = 0.03), asthma (hazard ratio, 1.88 [1.15-3.07], P = 0.01), and acute severe exacerbations (hazard ratio 2.66 [1.58-4.48], P value = 0.0002).
|
19029000 |
2009 |
|
rs4742170
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This mechanism may explain the negative effect of the rs4742170 (T) risk allele on the development of wheezing phenotype that strongly correlates with allergic sensitization in childhood.
|
30544846 |
2018 |
|
rs4742170
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Intermediate-onset wheeze was associated with SNPs in several genes in the IL33-IL1RL1 pathway after applying multiple testing correction in the meta-analysis: 2 IL33 SNPs (rs4742170 and rs7037276), 1 IL-1 receptor accessory protein (IL1RAP) SNP (rs10513854), and 1 TRAF6 SNP (rs5030411).
|
24568840 |
2014 |
|
rs20541
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SNP rs1800925, SNP rs20541 and SNP rs848 were significantly associated with increased risks on childhood wheeze with FDR of 0.03, 0.04 and 0.04, respectively.
|
23382814 |
2013 |
|
rs1695
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A suggestive interaction with early maternal smoking was also seen for three GSTP1 SNPs (Intron 5, Intron 6 and Ile105Val) with respect to transient wheeze, but not for ADRB2 and wheeze phenotypes.
|
20210814 |
2010 |
|
rs20541
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There was a statistically significant association between the IL-13 Arg144Gln polymorphism and risk of recurrent wheeze (p = 0.01).
|
19674346 |
2009 |
|
rs1695
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Using SNP- and haplotype-based approaches, the effect of maternal smoking on wheezing was largest in children with the Ile105Val allele.
|
18335111 |
2008 |
|
rs408223
|
|
|
0.010 |
GeneticVariation |
BEFREE |
GAC haplotype from rs4730125, rs6967330, and rs408223 was associated with pre-school current wheeze and school-age asthma.
|
31610042 |
2020 |
|
rs28929474
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only rs28929474, the most common pathologic SNP (Pi*Z) in the SERPINA1 gene, might be associated with a risk of developing school-age asthma without exhibiting preschool wheeze.
|
31298815 |
2019 |
|
rs1800470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found an association between rs1800470 (C allele) and atopic wheezing (odds ratio [OR], 0.60; 95% confidence interval [CI], 0.37-0.95) and markers of allergy (OR, 0.41; 95% CI, 0.22-0.79).
|
28284979 |
2017 |
|
rs1800890
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IL-10 polymorphisms at rs1800871, rs1800872, rs1800890, and rs1800896 seem to be associated with elevated allergies and/or recurrent wheezing risk in later childhood, after early-life bronchiolitis.Pediatr Pulmonol.2017;52:14-20.© 2016 Wiley Periodicals, Inc.
|
27228545 |
2017 |
|
rs1800896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IL-10 polymorphisms at rs1800871, rs1800872, rs1800890, and rs1800896 seem to be associated with elevated allergies and/or recurrent wheezing risk in later childhood, after early-life bronchiolitis.Pediatr Pulmonol.2017;52:14-20.© 2016 Wiley Periodicals, Inc.
|
27228545 |
2017 |
|
rs2070874
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between the TT-genotype of IL-4 rs2070874 polymorphism and a severe phenotype of viral-induced wheeze further underlines the role IL-4 plays in the inflammation pathway leading to viral respiratory infections.
|
28950434 |
2017 |
|
rs10767664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped 85,437 individuals aged 20-100 years from the Copenhagen General Population Study for FTO (rs9939609), MC4R (rs17782313), TMEM18 (rs6548238) GNPDA2 (rs10938397) and BDNF (rs10767664); 14,500 individuals experienced wheezing and 5406 had asthma.
|
26504195 |
2016 |
|
rs10938397
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped 85,437 individuals aged 20-100 years from the Copenhagen General Population Study for FTO (rs9939609), MC4R (rs17782313), TMEM18 (rs6548238) GNPDA2 (rs10938397) and BDNF (rs10767664); 14,500 individuals experienced wheezing and 5406 had asthma.
|
26504195 |
2016 |
|
rs187084
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Post-bronchiolitis wheezing is associated with toll-like receptor 9 rs187084 gene polymorphism.
|
27498757 |
2016 |
|
rs2280090
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multiple associations were observed for ADAM33: rs2280090 was associated with reduced MEF240% (i.e., the ratio of Mean Expiratory Flow after 240s of hypertonic saline inhalation with respect to the age- and ancestry-matched reference value) and with an increased risk of allergic bronchitis (p = 1.77*10(-4) and p = 7.94*10(-4), respectively); rs3918396 was associated with wheezing and eczema comorbidity (p = 3.41*10(-4)).
|
27624002 |
2016 |
|
rs3093664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Higher HDL-C levels were noted in carriers of genotype GG of polymorphism TNFa rs3093664 that was protective for wheezing Vs AG and AA genotypes (65.3 Vs 51.8 and 53.3 mg/dl, p-value < 0.001 and p-value for trend = 0.028).
|
27411394 |
2016 |
|
rs3918396
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multiple associations were observed for ADAM33: rs2280090 was associated with reduced MEF240% (i.e., the ratio of Mean Expiratory Flow after 240s of hypertonic saline inhalation with respect to the age- and ancestry-matched reference value) and with an increased risk of allergic bronchitis (p = 1.77*10(-4) and p = 7.94*10(-4), respectively); rs3918396 was associated with wheezing and eczema comorbidity (p = 3.41*10(-4)).
|
27624002 |
2016 |