|
rs121913409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Primary sporadic DTFs harboring a CTNNB1 S45F mutation have a higher risk of recurrence after surgery compared to T41A, S45P, and WT DTF, but this association seems to be mediated by tumor size.
|
31804402 |
2019 |
|
rs121913409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
This study examines whether the different CTNNB1 mutants (T41A, S45F) occurring in DTF tumors differentially affect Wnt signaling activity, which might explain the different disease course between DTF patients harboring different CTNNB1 mutations.
|
30528042 |
2019 |
|
rs121913409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Furthermore, the combination of hydroxychloroquine and sorafenib enhances the antiproliferative and proapoptotic effects in S45F-mutated DT cells, suggesting that profiling β-catenin status could guide clinical management of desmoid patients who are considering sorafenib treatment.
|
30980399 |
2019 |
|
rs121913409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The majority of desmoid tumors are related to T41A and S45F mutations of the beta-catenin encoding gene (CTNNB1).
|
29330550 |
2018 |
|
rs121913409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We demonstrated that mutated DFs (T41A or S45F) and WT are two distinct molecular subgroups with regard to β-catenin stability, α-catenin affinity, and gene expression profiling.
|
28627792 |
2017 |
|
rs121913409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The specific S45F mutation has been reported to be associated with a more aggressive clinical course in DF.
|
26861905 |
2016 |
|
rs121913409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The other 3 patients showed a CTNNB1 mutation in the original desmoid-type fibromatosis (2 with a T41A and 1 with an S45F mutation), which was absent in the sarcoma.
|
26414222 |
2015 |
|
rs121913409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
CTNNB1 S45F mutation predicts poor efficacy of meloxicam treatment for desmoid tumors: a pilot study.
|
24788118 |
2014 |
|
rs121913409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
This series confirmed that primary, completely resected, sporadic DTs with the S45F mutation have a greater tendency for local recurrence.
|
23913621 |
2013 |
|
rs121913412
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our findings suggest that the response to sorafenib differs when comparing S45F-mutated DTs and T41A-mutated or wild-type DTs.
|
30980399 |
2019 |
|
rs121913412
|
|
|
0.060 |
GeneticVariation |
BEFREE |
No statistically significant difference in relative expression levels of Wnt target genes AXIN2, DKK1 and CCND1 was identified between either CTNNB1 wild-type, S45F or T41A mutated DTF samples.
|
30528042 |
2019 |
|
rs121913412
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The majority of desmoid tumors are related to T41A and S45F mutations of the beta-catenin encoding gene (CTNNB1).
|
29330550 |
2018 |
|
rs121913412
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We demonstrated that mutated DFs (T41A or S45F) and WT are two distinct molecular subgroups with regard to β-catenin stability, α-catenin affinity, and gene expression profiling.
|
28627792 |
2017 |
|
rs121913412
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Only 1 NMC had no detectable CTNNB1 mutation; however, the patient's subsequent NMC-fibromatosis had a CTNNB1 p.T41A mutation.
|
27259010 |
2016 |
|
rs121913412
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The other 3 patients showed a CTNNB1 mutation in the original desmoid-type fibromatosis (2 with a T41A and 1 with an S45F mutation), which was absent in the sarcoma.
|
26414222 |
2015 |
|
rs1171472831
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three patients showed a CTNNB1 hotspot mutation (T41A, S45F, or S45N) in both the desmoid-type fibromatosis and the radiation-induced sarcoma.
|
26414222 |
2015 |