|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This work showed that the interaction between the ADD1 rs4961 variant, obesity, and the presence of diabetes increased the susceptibility to EH four-fold.
|
28872890 |
2017 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This association remained statistically significant after the multivariate analysis (odds ratio 2.548, P = .02).The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with EH risk in our population.
|
29049185 |
2017 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we observed a significant association between rs4961 and EH under the dominant model after Bonferroni correction when adjusting for confounding factors in the entire sample (odds ratio (OR)=0.64, 95% confidence interval (CI)=0.50-0.83, P=0.001).
|
25567773 |
2015 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
All studies analyzing the association between ADD1 Gly460Trp polymorphism and EH risk were included.
|
26042478 |
2015 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471).
|
26335431 |
2015 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a Chinese population of mixed ethnicity, the α-adducin G460W gene polymorphism was linked to EH susceptibility, most strongly in Han Chinese.
|
22272309 |
2012 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, our findings supported the hypothesis that the ADD1 Gly460Trp polymorphism is associated with EH in the Chinese population.
|
21228790 |
2011 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our case-control study provided no evidence for the association of G460W with essential hypertension, even under assumptions of three genetic modes of inheritance (P>0.05).
|
19960031 |
2010 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Sodium-lithium countertransport and the Gly460-->Trp alpha-adducin polymorphism in essential hypertension.
|
15554870 |
2005 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Alpha-adducin Gly460Trp polymorphism and renal hemodynamics in essential hypertension.
|
15326084 |
2004 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Alpha-adducin Gly460Trp polymorphism and essential hypertension in Korea.
|
15608390 |
2004 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present findings show a positive association between the alpha-adducin G460W polymorphism and essential hypertension in a northern Chinese population.
|
14508192 |
2003 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The substitution of tryptophan for glycine at amino acid 460 (Gly460Trp polymorphism) of the alpha-subunit of the heterodimeric cytoskeleton protein adducin increases renal sodium reabsorption and may be involved in the pathophysiology of essential hypertension.
|
12427140 |
2002 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Gly460Trp polymorphism of the alpha-adducin gene (ADD-1 ) has been examined as a candidate gene for essential hypertension with salt sensitivity in the Caucasian population.
|
12195119 |
2002 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study was designed to examine the linkage between alpha-adducin gene locus and essential hypertension and to reveal the relationship between an alpha-adducin gene polymorphism (Gly460Trp) and essential hypertension in a Chinese population.
|
11710759 |
2001 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Role of the Gly460Trp polymorphism of the alpha-adducin gene in primary hypertension in Scandinavians.
|
10673730 |
2000 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies have found the tryptophan allele of a glycine to tryptophan polymorphism at position 460 (G460W) of the alpha-adducin protein to be associated with essential hypertension in European populations.
|
10912757 |
2000 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A Gly460Trp variant of the cytoskeletal protein alpha-adducin has recently been implicated in the etiology of essential hypertension (HT) in a study involving southern European whites.
|
10371374 |
1999 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated whether an alpha-adducin polymorphism (Gly 460 Trp) is involved in essential hypertension in two separate populations.
|
9149697 |
1997 |
|
rs3755885
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Under additive, dominant and recessive models, no significant associations were evidenced between EH and rs3755885, rs2071694, rs4963 or rs3775067 with the complete data set or the gender-stratified analysis after adjusting for triglycerides, body mass index and alcohol consumption.
|
25567773 |
2015 |
|
rs4963
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study indicated that rs496</span>3</span> within ADD1 gene was associated with esse</span>ntial hypertension in Chinese population, which might be related to altered exonic splicing and disrupted gene regulation.
|
23509723 |
2013 |
|
rs201637172
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both newly detected TSC C1784T and ADRB3 T727C are gene polymorphisms susceptible to the antihypertensive effect of TZDs in patients with EHT.
|
15824464 |
2004 |