|
rs35771982
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Genotype and allele distribution of rs35771982 and rs4664308 differed significantly between PLA2R-Ab(+) and PLA2R-Ab(-) IMN patients in Group B (OR = 1.59 (1.09-2.31), <i>P</i> = 0.018 and OR = 1.15 (1.03-1.29), <i>P</i> = 0.005, respectively).
|
31532353 |
2020 |
|
rs35771982
|
|
|
0.050 |
GeneticVariation |
BEFREE |
There are some differences in PLA2R1 SNP distributions between previously reported cohorts from other countries and our Japanese cohort of patients with iMN, while there is a significant association between SNP rs35771982 and iMN in most of reported cohorts.
|
28849274 |
2018 |
|
rs35771982
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Furthermore, positive interaction was also observed between HLA-DRB1*15:01 - HLA-DQB1*06:02 and the missense SNP rs35771982 (OR = 15.91, P = 2.76E-29), which is in strong linkage disequilibrium with 5'UTR SNP rs3749119, and intronic SNP rs16844715 (OR = 15.91, P = 2.30E-26) for IMN.
|
27934873 |
2016 |
|
rs35771982
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Subjects with the CC genotype in rs35771982 had a higher susceptibility to idiopathic MN compared to subjects with other genotypes (odds ratio 2.6; 95% confidence interval 1.8-4.0).
|
20805699 |
2011 |
|
rs35771982
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Genotype distribution was significantly different between patients with IMN and controls for PLA2R1 SNP rs35771982 (p = 0.015).
|
20937089 |
2010 |
|
rs2187668
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our pooled analysis showed a significant association between rs2187668-(A) allele and iMN susceptibility, and the intervention of this mutation might bring new therapeutic strategy for iMN.
|
30383665 |
2018 |
|
rs2187668
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Allelic frequency distributions for SNP rs2187668 within HLA-DQA1 were significantly different between the iMN and control groups.
|
28849274 |
2018 |
|
rs2187668
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Even under dominant model, the two SNPs were still significantly associated with IMN (P = 3.50×10-3 for rs28383345 and P = 6.55×10-5 for rs2187668).
|
28685717 |
2017 |
|
rs2187668
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We believe this will be a valuable technique for determining the genotype of rs2187668 and rs4664308 and for assessing individual susceptibility to IMN.
|
23194743 |
2013 |
|
rs4664308
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genotype and allele distribution of rs35771982 and rs4664308 differed significantly between PLA2R-Ab(+) and PLA2R-Ab(-) IMN patients in Group B (OR = 1.59 (1.09-2.31), <i>P</i> = 0.018 and OR = 1.15 (1.03-1.29), <i>P</i> = 0.005, respectively).
|
31532353 |
2020 |
|
rs4664308
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We believe this will be a valuable technique for determining the genotype of rs2187668 and rs4664308 and for assessing individual susceptibility to IMN.
|
23194743 |
2013 |
|
rs2715918
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotypic and allelic frequency distributions for 3 out of 6 SNPs within PLA2R1, rs3749117, rs35771982, and rs2715918 were significantly different between the iMN and control groups.
|
28849274 |
2018 |
|
rs875
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study revealed the association of PPP3R1 3'UTR polymorphism rs875 with the efficacy of tacrolimus in IMN patients.
|
30388516 |
2018 |
|
rs28383345
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Even under dominant model, the two SNPs were still significantly associated with IMN (P = 3.50×10-3 for rs28383345 and P = 6.55×10-5 for rs2187668).
|
28685717 |
2017 |
|
rs660895
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Conditional logistic regression analysis displayed that SNPs protective from IMN (odds ratio < 1.00) were still significantly associated with IMN (p = 3.67E-4 for rs660895 and p = 1.26E-4 for rs9275224) with the most significant SNP rs9275596 as a covariate.
|
28929317 |
2017 |
|
rs9275224
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Conditional logistic regression analysis displayed that SNPs protective from IMN (odds ratio < 1.00) were still significantly associated with IMN (p = 3.67E-4 for rs660895 and p = 1.26E-4 for rs9275224) with the most significant SNP rs9275596 as a covariate.
|
28929317 |
2017 |
|
rs9275596
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Conditional logistic regression analysis displayed that SNPs protective from IMN (odds ratio < 1.00) were still significantly associated with IMN (p = 3.67E-4 for rs660895 and p = 1.26E-4 for rs9275224) with the most significant SNP rs9275596 as a covariate.
|
28929317 |
2017 |
|
rs16844715
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, positive interaction was also observed between HLA-DRB1*15:01 - HLA-DQB1*06:02 and the missense SNP rs35771982 (OR = 15.91, P = 2.76E-29), which is in strong linkage disequilibrium with 5'UTR SNP rs3749119, and intronic SNP rs16844715 (OR = 15.91, P = 2.30E-26) for IMN.
|
27934873 |
2016 |
|
rs2715928
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition to the two SNPs previously reported to be strongly associated with IMN, rs3749119 and rs35771982 (OR 3.02 and 2.93, P = 3.24E-14 and 4.64E-14, respectively), two novel intronic SNPs (rs2715928 and rs16844715) were also identified as IMN-associated SNPs (OR = 2.30 and 2.51, P = 3.15E-10 and 5.66E-13, respectively).
|
27934873 |
2016 |
|
rs3749119
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, positive interaction was also observed between HLA-DRB1*15:01 - HLA-DQB1*06:02 and the missense SNP rs35771982 (OR = 15.91, P = 2.76E-29), which is in strong linkage disequilibrium with 5'UTR SNP rs3749119, and intronic SNP rs16844715 (OR = 15.91, P = 2.30E-26) for IMN.
|
27934873 |
2016 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we report on an arterial thrombosis in a young girl with idiopathic membranous glomerulonephritis associated with heterozygous factor V Leiden and homozygous MTHFR C677T mutation.
|
18030499 |
2008 |