|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In addition, BRAF V600E mutations have been associated with oncogene-induced senescence in other benign tumors, providing clues to the pathogenesis of metanephric neoplasms in keeping with their overall benign behavior.
|
27769870 |
2017 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
GISTs with the BRAF V600E mutation are relatively benign tumors with a distinctive molecular mechanism.
|
28034324 |
2017 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
GISTs with the BRAF V600E mutation are relatively benign tumors with a distinctive molecular mechanism.
|
28034324 |
2017 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In addition, BRAF V600E mutations have been associated with oncogene-induced senescence in other benign tumors, providing clues to the pathogenesis of metanephric neoplasms in keeping with their overall benign behavior.
|
27769870 |
2017 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The presence of BRAF V600E and mitogen-activated protein kinase activation in a largely benign tumor supports the necessity for secondary events (e.g., p16 loss) in BRAF-driven oncogenesis.
|
22727996 |
2012 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To investigate the role of DUSP6 in the regulation of ERK1/2 (MAPK3/1)-dependent transcription, 42 benign neoplasms and 167 PTCs were retrospectively analyzed by immunohistochemistry with dideoxy sequencing to detect BRAF(V600E) mutation.
|
22535643 |
2012 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To investigate the role of DUSP6 in the regulation of ERK1/2 (MAPK3/1)-dependent transcription, 42 benign neoplasms and 167 PTCs were retrospectively analyzed by immunohistochemistry with dideoxy sequencing to detect BRAF(V600E) mutation.
|
22535643 |
2012 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The presence of BRAF V600E and mitogen-activated protein kinase activation in a largely benign tumor supports the necessity for secondary events (e.g., p16 loss) in BRAF-driven oncogenesis.
|
22727996 |
2012 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Human naevi (moles) are benign tumours of melanocytes that frequently harbour oncogenic mutations (predominantly V600E, where valine is substituted for glutamic acid) in BRAF, a protein kinase and downstream effector of Ras.
|
16079850 |
2005 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Human naevi (moles) are benign tumours of melanocytes that frequently harbour oncogenic mutations (predominantly V600E, where valine is substituted for glutamic acid) in BRAF, a protein kinase and downstream effector of Ras.
|
16079850 |
2005 |
|
rs78378222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five variants were previously reported to confer risk of various malignant or benign tumors (rs78378222 in TP53, rs10069690 in TERT, rs1800057 and rs1801516 in ATM, and rs7907606 at OBFC1) and four signals are located at established risk loci for hormone-related traits (endometriosis and breast cancer) at 1q36.12 (CDC42/WNT4), 2p25.1 (GREB1), 20p12.3 (MCM8), and 6q26.2 (SYNE1/ESR1).
|
30194396 |
2018 |
|
rs9344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype AA of rs9344 was associated with high expression of <i>CCND1b</i> mRNA and was more frequently found in thyroid cancer than in benign tumors.
|
30428594 |
2018 |
|
rs2292832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus far, the role of rs2292832 in PTC tumorigenesis and progression was unclear; (2) METHOD: Rs2292832 was genotyped in 838 PTCs, 495 patients with thyroid benign tumors (BNs) and 1006 controls in a Chinese Han population.
|
25405731 |
2014 |
|
rs1131691021
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas the successive expression of Ras(G12V) and p53(DD) led to highly malignant tumors with metastatic behavior, reminiscent of those formed after the simultaneous introduction of p53(DD) and Ras(G12V), the reverse sequence gave rise only to benign tumors.
|
22589739 |
2012 |
|
rs762846821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas the successive expression of Ras(G12V) and p53(DD) led to highly malignant tumors with metastatic behavior, reminiscent of those formed after the simultaneous introduction of p53(DD) and Ras(G12V), the reverse sequence gave rise only to benign tumors.
|
22589739 |
2012 |