|
rs11571833
|
|
|
0.720 |
GeneticVariation |
BEFREE |
More importantly, rare, deleterious germline variants were enriched in <i>Fanconi anemia</i> genes even without the <i>BRCA2</i> rs11571833 variant that is strongly enriched in lung SqCC cases (joint OR = 2.76; <i>P</i> = 7.0e-04; 95% CI, 1.6-4.7).
|
30425093 |
2019 |
|
rs11571833
|
|
|
0.720 |
GeneticVariation |
BEFREE |
A rare truncating BRCA2 genetic variant, rs11571833 (K3326X), has been associated with a 2.5-fold risk of lung squamous cell carcinoma but only a modest 26% increase in breast cancer risk.
|
25838448 |
2015 |
|
rs121913482
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Six (1.2%) FGFR3 activating mutations were identified in lung squamous cell carcinoma (five S249C and one R248C).
|
26486077 |
2015 |
|
rs121913483
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Six (1.2%) FGFR3 activating mutations were identified in lung squamous cell carcinoma (five S249C and one R248C).
|
26486077 |
2015 |
|
rs10118570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We concluded that mitogen-activated protein kinase associated protein 1 rs10118570 may be an important protective factor for developing better management strategies in lung squamous cell carcinoma.
|
24926550 |
2014 |
|
rs1042522
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms.
|
17059853 |
2007 |
|
rs1048943
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung.
|
16195240 |
2006 |
|
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although our sample size was limited, these results indicate that the Ser326Cys variant may be related to squamous cell lung cancer susceptibility.
|
10744126 |
1999 |
|
rs1057519847
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A subsequent advanced SCC bearing EGFR L858R/T790M mutations occurred 3 years after surgery.
|
28272214 |
2017 |
|
rs1057519848
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A subsequent advanced SCC bearing EGFR L858R/T790M mutations occurred 3 years after surgery.
|
28272214 |
2017 |
|
rs1057520001
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms.
|
17059853 |
2007 |
|
rs1060501327
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that XRCC3 Thr241Met may act as a favorable prognostic indicator for lung squamous cell carcinoma patients.
|
23443124 |
2012 |
|
rs10845498
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The LRP6 rs10845498 SNP is associated with a reduced risk of lung SCC, while tobacco smoke increases the risk.
|
24843317 |
2014 |
|
rs10849605
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We additionally identified rs10849605</span> as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels.
|
25793373 |
2015 |
|
rs1131691014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms.
|
17059853 |
2007 |
|
rs121434568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A subsequent advanced SCC bearing EGFR L858R/T790M mutations occurred 3 years after surgery.
|
28272214 |
2017 |
|
rs121434592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung.
|
18256540 |
2008 |
|
rs121913376
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, we found a novel B-RAF V470F mutation in lung squamous cell carcinoma that showed response to gefitinib.
|
17409805 |
2007 |
|
rs1367644026
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygous or heterozygous TGFβRII deletion in mouse airway epithelia increases the size and number of Kras(G12D)-initiated adenocarcinoma and SCC.
|
22399565 |
2012 |
|
rs16901904
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in rs710886 and rs16901904 were observed to be associated with lung squamous cell carcinoma risk (CC+CT vs. TT: OR<sup>a</sup> = 0.638, <i>p</i>* = 0.040 for rs710886; CC vs. TT: OR<sup>a</sup> = 2.582, <i>p</i>* = 0.033 and CC vs. TT+CT: OR<sup>a</sup> = 2.381, <i>p</i>* = 0.048 for rs16901904).
|
31464517 |
2019 |
|
rs1801270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms.
|
17059853 |
2007 |
|
rs201701502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A mutation (T681I) identified in lung SQCC and the cell line EBC-1 was detected among 44 primary lung SQCC samples and 7 lung SQCC cell lines.
|
28676216 |
2017 |
|
rs2070600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, eQTL analysis indicated that the rs2070600 polymorphism may modify the expression level of RAGE in lung squamous cell carcinoma tissues (P = 0.09).
|
29421442 |
2018 |
|
rs2151280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, there was no significant association between rs2151280 and lung squamous cell carcinoma risk in five models.
|
31775885 |
2019 |
|
rs2233947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
EGFR rs2233947 correlated with lung cancer in males, smokers, and in the squamous cell carcinoma lung cancer subtype (P<0.01).
|
31518089 |
2019 |