Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2239895
rs2239895
NEAT1 ; LOC107984338
0.010 GeneticVariation BEFREE The polymorphisms rs2239895 were associated with the risk of lung squamous cell carcinoma. 31704150

2019
dbSNP: rs2835267
rs2835267
SETD4 ; LOC100133286
0.010 GeneticVariation BEFREE The CBR1 rs3787728 cytosine (C)/C allele homozygote was associated with a decreased risk of adenocarcinoma (ADC) in male patients (OR=0.633; 95% CI=0.413-0.969; P=0.0348); however, no significant association was observed in CBR1 rs2835267 between SNPs and SCC or ADC-type NSCLC. 29113280

2017
dbSNP: rs3787728
rs3787728
CBR1 ; SETD4 ; LOC100133286
0.010 GeneticVariation BEFREE The CBR1 rs3787728 thymine (T)/T allele homozygote was associated with an increased risk of NSCLC in all patients (OR=1.382; 95% CI=1.019-1.875; P=0.037), and patients possessing the rs3787728 T/T major allele homozygote exhibited a 1.537-fold greater risk with respect to developing lung squamous-cell carcinoma (SCC) in all patients (95% CI=1.019-2.318; P=0.0395). 29113280

2017
dbSNP: rs401681
rs401681
CLPTM1L
0.010 GeneticVariation BEFREE Additionally, in a subgroup analysis by histology type, the CLPTM1L rs401681 polymorphism was found to significantly decrease the risks of both adenocarcinoma and squamous cell carcinoma of the lung in all genetic models. 24634236

2014
dbSNP: rs4513061
rs4513061
AGBL1
0.010 GeneticVariation BEFREE The stratified analysis suggested the protective effect of rs4513061 to different histological types of lung cancer, including lung adenocarcinoma (AA vs. GG: odds ratio [OR] = 0.505, 95% confidence interval [CI] = 0.337-0.756, <i>p</i> < 0.001), squamous cell lung cancer (AG vs. GG: OR = 0.488, 95% CI = 0.269-0.883, <i>p</i> = 0.018), and small-cell lung cancer (AA vs. GG: OR = 0.421, 95% CI = 0.216-0.819, <i>p</i> = 0.011). 31603707

2019
dbSNP: rs6183
rs6183
GHR
0.010 GeneticVariation BEFREE In different histological types of lung cancer, Thr495Pro SNP was significantly associated with small cell and squamous cell lung cancer, but not with adenocarcinoma, which suggested a potential interaction between this polymorphism and metabolic pathways related to smoking. 18299312

2008
dbSNP: rs6488507
rs6488507
LRP6 ; BCL2L14
0.010 GeneticVariation BEFREE Logistic regression analysis revealed that the LRP6 rs10845498 A/A major allele was associated with a reduced risk in developing lung SCC (OR = 0.69; 95% CI, 0.48-1.00; P=0.04), and tobacco smokers had a 2.21 fold greater risk in developing SCC than nonsmokers (p<0.01, 95% CI, 1.72-2.85), and tobacco smokers who carried an "A" allele (AA+AG) in rs6488507 had a 2.34-fold greater risk in developing NSCLC than other patients (p< 0.01, 95%CI, 1.74-3.13). 24843317

2014
dbSNP: rs6489769
rs6489769
RAD52
0.010 GeneticVariation BEFREE We identified a susceptibility locus for squamous cell lung carcinoma at 12p13.33 (RAD52, rs6489769) and replicated the association in 3 independent studies totaling 3,359 squamous cell lung carcinoma cases and 9,100 controls (OR = 1.20, P(combined) = 2.3 × 10(-8)). 22585858

2012
dbSNP: rs710886
rs710886
PCAT1 ; LOC105375751
0.010 GeneticVariation BEFREE Polymorphisms in rs710886 and rs16901904 were observed to be associated with lung squamous cell carcinoma risk (CC+CT vs. TT: OR<sup>a</sup> = 0.638, <i>p</i>* = 0.040 for rs710886; CC vs. TT: OR<sup>a</sup> = 2.582, <i>p</i>* = 0.033 and CC vs. TT+CT: OR<sup>a</sup> = 2.381, <i>p</i>* = 0.048 for rs16901904). 31464517

2019
dbSNP: rs754400800
rs754400800
NRG1
0.010 GeneticVariation BEFREE Six (1.2%) FGFR3 activating mutations were identified in lung squamous cell carcinoma (five S249C and one R248C). 26486077

2015
dbSNP: rs861539
rs861539
KLC1 ; XRCC3
0.010 GeneticVariation BEFREE Our results suggest that XRCC3 Thr241Met may act as a favorable prognostic indicator for lung squamous cell carcinoma patients. 23443124

2012
dbSNP: rs876658657
rs876658657
MLH1
0.010 GeneticVariation BEFREE These results suggest that the hMLH1 -93G-->A polymorphism could be used as a marker of genetic susceptibility to squamous cell carcinoma of the lung. 15382050

2004
dbSNP: rs878854066
rs878854066
TP53
0.010 GeneticVariation BEFREE Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms. 17059853

2007
dbSNP: rs886039484
rs886039484
TP53
0.010 GeneticVariation BEFREE Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms. 17059853

2007
dbSNP: rs121913482
rs121913482
FGFR3
T 0.710 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913483
rs121913483
FGFR3
G 0.710 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs1023835002
rs1023835002
B2M ; PATL2
T 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs1023835002
rs1023835002
B2M ; PATL2
G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs104886003
rs104886003
PIK3CA
C 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs104886003
rs104886003
PIK3CA
A 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs104894104
rs104894104
CDKN2A
T 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs104894226
rs104894226
HRAS ; LRRC56
A 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs104894228
rs104894228
HRAS ; LRRC56
G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs104894228
rs104894228
HRAS ; LRRC56
T 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs104894228
rs104894228
HRAS ; LRRC56
A 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016