|
rs4986790
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The TLR4 ASP299GLY polymorphism is a risk factor for active tuberculosis in Caucasian HIV-infected patients.
|
20226000 |
2010 |
|
rs4986790
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found a greater risk of developing active tuberculosis as well as a reduction in CD4 T-cell counts in patients with the Asp299Gly TLR4 polymorphism.
|
17545720 |
2007 |
|
rs187238
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study was performed to investigate whether two promoter polymorphisms of the IL-18 gene at positions -137G/A (rs187238) and -607A/C (rs1946518) affect the serum level of IL-18 and might be associated with genetic susceptibility to tuberculosis (TB) in the Polish population.
|
31301271 |
2019 |
|
rs1946518
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study was performed to investigate whether two promoter polymorphisms of the IL-18 gene at positions -137G/A (rs187238) and -607A/C (rs1946518) affect the serum level of IL-18 and might be associated with genetic susceptibility to tuberculosis (TB) in the Polish population.
|
31301271 |
2019 |
|
rs35037722
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, males exhibited GG homozygous at rs35037722 in association with susceptibility to TB after the OR analysis was adjusted for age.
|
30580155 |
2019 |
|
rs73226617
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identify a novel association between early TB progression and variants located in a putative enhancer region on chromosome 3q23 (rs73226617, OR = 1.18; P = 3.93 × 10<sup>-8</sup>).
|
31434886 |
2019 |
|
rs8064821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For rs8064821, AA and AC genotypes were associated with TB susceptibility in patients ≤ 65 years old compared to CC genotype, whereas older subjects had no such association.
|
30580155 |
2019 |
|
rs3764880
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A-allele of TLR8 rs3764880 SNP was protective against the development of TB in males (A vs G, OR = 0.58, 95%CI = 0.37-0.91).
|
30424735 |
2018 |
|
rs1718119
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele A of rs1718119 was related to a reduced risk for all active tuberculosis (OR for each additional allele A: 0.81, 95% CI: 0.69-0.94) and sputum smear-positive cases (OR for each additional allele A: 0.78, 95% CI: 0.66-0.93).
|
28495473 |
2017 |
|
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, our findings demonstrated that the AA genotype from the IL-17A rs2275913 SNP is positively associated with protection to active tuberculosis but related to higher disease severity in the Argentinean population.
|
28098168 |
2017 |
|
rs10500804
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analyses were conducted to test for main effects of vitamin D status and SNPs in VDR (rs731236, rs2228570 and rs1544410), DBP (rs7041 and rs4588) and CYP2R1 (rs2060793, rs10500804 and rs10766197) on susceptibility to TB, and to investigate whether these SNPs modify the association between vitamin D status and disease susceptibility.
|
27160686 |
2016 |
|
rs10766197
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analyses were conducted to test for main effects of vitamin D status and SNPs in VDR (rs731236, rs2228570 and rs1544410), DBP (rs7041 and rs4588) and CYP2R1 (rs2060793, rs10500804 and rs10766197) on susceptibility to TB, and to investigate whether these SNPs modify the association between vitamin D status and disease susceptibility.
|
27160686 |
2016 |
|
rs12212067
|
|
|
0.010 |
GeneticVariation |
BEFREE |
FOXO3 rs12212067: T > G Association with Active Tuberculosis in Han Chinese Population.
|
26223437 |
2016 |
|
rs1544410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analyses were conducted to test for main effects of vitamin D status and SNPs in VDR (rs731236, rs2228570 and rs1544410), DBP (rs7041 and rs4588) and CYP2R1 (rs2060793, rs10500804 and rs10766197) on susceptibility to TB, and to investigate whether these SNPs modify the association between vitamin D status and disease susceptibility.
|
27160686 |
2016 |
|
rs2060793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analyses were conducted to test for main effects of vitamin D status and SNPs in VDR (rs731236, rs2228570 and rs1544410), DBP (rs7041 and rs4588) and CYP2R1 (rs2060793, rs10500804 and rs10766197) on susceptibility to TB, and to investigate whether these SNPs modify the association between vitamin D status and disease susceptibility.
|
27160686 |
2016 |
|
rs4588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analyses were conducted to test for main effects of vitamin D status and SNPs in VDR (rs731236, rs2228570 and rs1544410), DBP (rs7041 and rs4588) and CYP2R1 (rs2060793, rs10500804 and rs10766197) on susceptibility to TB, and to investigate whether these SNPs modify the association between vitamin D status and disease susceptibility.
|
27160686 |
2016 |
|
rs4921437
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A common variant, rs4921437 at 5q33.3, was significantly associated with TB (odds ratio = 0.37, p = 2.11 × 10(-8)).
|
26942285 |
2016 |
|
rs7041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analyses were conducted to test for main effects of vitamin D status and SNPs in VDR (rs731236, rs2228570 and rs1544410), DBP (rs7041 and rs4588) and CYP2R1 (rs2060793, rs10500804 and rs10766197) on susceptibility to TB, and to investigate whether these SNPs modify the association between vitamin D status and disease susceptibility.
|
27160686 |
2016 |
|
rs3135932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated the relationship of IL-10R1 S138G loss-of-function polymorphism (A536G: rs3135932) with susceptibility to active tuberculosis (TB) in Tunisian patients.
|
21553229 |
2012 |
|
rs2107538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study investigated the relationship between the RANTES polymorphisms (-28C/G; rs2280788, and -403G/A; rs2107538) and susceptibility to active tuberculosis (TB) in Tunisian populations.
|
21510799 |
2011 |
|
rs2280788
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study investigated the relationship between the RANTES polymorphisms (-28C/G; rs2280788, and -403G/A; rs2107538) and susceptibility to active tuberculosis (TB) in Tunisian populations.
|
21510799 |
2011 |
|
rs17722851
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multilocus analyses between polymorphisms in SLC11A1 and 11 TB candidate genes detected interactions between SLC11A1 and inducible nitric oxide synthase (NOS2A) in Caucasians (rs3731863 [SLC11A1] x rs8073782 [NOS2A], P = 0.009; rs3731863 [SLC11A1] x rs17722851 [NOS2A], P = 0.007) and toll-like receptor 2 (TLR2) in African-Americans (rs3731865 [SLC11A1] x rs1816702, P = 0.005).
|
19723394 |
2009 |
|
rs1816702
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multilocus analyses between polymorphisms in SLC11A1 and 11 TB candidate genes detected interactions between SLC11A1 and inducible nitric oxide synthase (NOS2A) in Caucasians (rs3731863 [SLC11A1] x rs8073782 [NOS2A], P = 0.009; rs3731863 [SLC11A1] x rs17722851 [NOS2A], P = 0.007) and toll-like receptor 2 (TLR2) in African-Americans (rs3731865 [SLC11A1] x rs1816702, P = 0.005).
|
19723394 |
2009 |
|
rs3731863
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multilocus analyses between polymorphisms in SLC11A1 and 11 TB candidate genes detected interactions between SLC11A1 and inducible nitric oxide synthase (NOS2A) in Caucasians (rs3731863 [SLC11A1] x rs8073782 [NOS2A], P = 0.009; rs3731863 [SLC11A1] x rs17722851 [NOS2A], P = 0.007) and toll-like receptor 2 (TLR2) in African-Americans (rs3731865 [SLC11A1] x rs1816702, P = 0.005).
|
19723394 |
2009 |
|
rs3731865
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SLC11A1 polymorphism rs3731865 was associated with TB in African-Americans, consistent with previous findings in West Africans.
|
19723394 |
2009 |