Gene: EGFR ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs28929495
rs28929495
EGFR
0.720 GeneticVariation BEFREE Long-term survival with erlotinib in advanced lung adenocarcinoma harboring synchronous EGFR G719S and KRAS G12C mutations. 29748019

2018
dbSNP: rs28929495
rs28929495
EGFR
0.720 GeneticVariation BEFREE We herein first report G719S mutation in lung adenocarcinoma with tonsillar metastasis. 29245278

2017
dbSNP: rs28929495
rs28929495
EGFR
T 0.720 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913444
rs121913444
EGFR
0.710 GeneticVariation BEFREE The patient was diagnosed with lung adenocarcinoma with an EGFR L861Q mutation based on cytological findings. 31779047

2020
dbSNP: rs121913444
rs121913444
EGFR
A 0.710 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913428
rs121913428
EGFR
C 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913428
rs121913428
EGFR
A 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913229
rs121913229
EGFR
C 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs139429793
rs139429793
EGFR
A 0.700 CausalMutation CLINVAR Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation. 24212795

2011
dbSNP: rs150036236
rs150036236
EGFR
A 0.700 CausalMutation CLINVAR Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma. 20942962

2010
dbSNP: rs121913229
rs121913229
EGFR
C 0.700 GeneticVariation CLINVAR Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. 15737014

2005
dbSNP: rs1554350382
rs1554350382
EGFR ; EGFR-AS1
AGTC 0.700 GeneticVariation CLINVAR

dbSNP: rs1057519847
rs1057519847
EGFR
0.100 GeneticVariation BEFREE Intense expression of L858R in the MP component was suggested, and the MP+ patients harboring L858R were at comparatively higher risk of recurrence in the group with pN0M0 lung adenocarcinoma. 31732945

2020
dbSNP: rs1057519848
rs1057519848
EGFR
0.100 GeneticVariation BEFREE Intense expression of L858R in the MP component was suggested, and the MP+ patients harboring L858R were at comparatively higher risk of recurrence in the group with pN0M0 lung adenocarcinoma. 31732945

2020
dbSNP: rs121434568
rs121434568
EGFR
0.100 GeneticVariation BEFREE Intense expression of L858R in the MP component was suggested, and the MP+ patients harboring L858R were at comparatively higher risk of recurrence in the group with pN0M0 lung adenocarcinoma. 31732945

2020
dbSNP: rs121434569
rs121434569
EGFR ; EGFR-AS1
0.100 GeneticVariation BEFREE Lower pre-treatment PD-L1 is associated with better ORR, PFS, and higher frequency of T790M resistance in EGFR TKI-treated lung ADC patients. 31760310

2020
dbSNP: rs1057519847
rs1057519847
EGFR
0.100 GeneticVariation BEFREE Unusual synchronous double primary treatment-naïve lung adenocarcinoma harboring T790M and L858R mutations in early-stage lung cancer. 31426797

2019
dbSNP: rs1057519847
rs1057519847
EGFR
0.100 GeneticVariation BEFREE Our study suggested the intratumoral heterogeneity of EGFR-activating mutations in lung adenocarcinoma confirmed on the single-cell level, which might be associated with EGFR-TKIs response in lung adenocarcinoma patients harboring the EGFR L858R mutation. 31014278

2019
dbSNP: rs1057519847
rs1057519847
EGFR
0.100 GeneticVariation BEFREE ctDNA of EGFR-TKI sensitizing mutations (mEGFR), L858R substitution and Exon 19 deletion (E19d) mutation, was evaluated using droplet digital PCR (ddPCR) in 81 patients with lung adenocarcinoma which harbored mEGFR in the corresponding tumor tissues. 31647198

2019
dbSNP: rs1057519847
rs1057519847
EGFR
0.100 GeneticVariation BEFREE Clinicopathologic information was analyzed and EGFR mutation results were performed in initial biopsy samples.Seven patients showed transformation from ADC to SCLC, of which 6 patients were 19 del EGFR mutation, only 1 patient is L858R mutations. 30896637

2019
dbSNP: rs1057519847
rs1057519847
EGFR
0.100 GeneticVariation BEFREE <i>EGFR</i> exon 19 deletions and L858R mutation in exon 21 are the most common sensitive mutations in lung adenocarcinoma. 31064887

2019
dbSNP: rs1057519847
rs1057519847
EGFR
0.100 GeneticVariation BEFREE A 55-year-old female with EGFR mutation (L858R) was diagnosed with lung adenocarcinoma, who was responsive to first-generation EGFR-tyrosine kinase inhibitor (TKI). 31382924

2019
dbSNP: rs1057519847
rs1057519847
EGFR
0.100 GeneticVariation BEFREE Patients with advanced lung adenocarcinoma with membranous mutant EGFR (19del or 21 L858R) showed significantly longer progression-free survival than those with cytoplasmic mutant EGFR after gefitinib treatment. 31228625

2019
dbSNP: rs1057519848
rs1057519848
EGFR
0.100 GeneticVariation BEFREE Our study suggested the intratumoral heterogeneity of EGFR-activating mutations in lung adenocarcinoma confirmed on the single-cell level, which might be associated with EGFR-TKIs response in lung adenocarcinoma patients harboring the EGFR L858R mutation. 31014278

2019
dbSNP: rs1057519848
rs1057519848
EGFR
0.100 GeneticVariation BEFREE Patients with advanced lung adenocarcinoma with membranous mutant EGFR (19del or 21 L858R) showed significantly longer progression-free survival than those with cytoplasmic mutant EGFR after gefitinib treatment. 31228625

2019