|
rs3825942
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.
|
17690259 |
2007 |
|
rs3825942
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.
|
17690259 |
2007 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The SNPs rs1048661 and rs3825942 of the LOXL1 gene seem to be highly associated with XFS in the Japanese population, but a different polymorphism of LOXL1 may cause the development of XFS in the Japanese population.
|
18201684 |
2008 |
|
rs1048661
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SNPs rs1048661 and rs3825942 of the LOXL1 gene seem to be highly associated with XFS in the Japanese population, but a different polymorphism of LOXL1 may cause the development of XFS in the Japanese population.
|
18201684 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These results indicate that the G153D LOXL1 variant is significantly associated with an increased risk of pseudoexfoliation and pseudoexfoliation glaucoma in an ethnically diverse patient population from the Northeastern United States.
|
18254956 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After a standard eye examination protocol we genotyped SNPs rs2165241and rs3825942 in 62 XFG or exfoliation syndrome (XFS) patients and 170 normal controls.
|
18287813 |
2008 |
|
rs2165241
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The SNP rs2165241 was significantly associated with XFG and XFS (p = 4.13 x 10(-9)) for an additive model, OR(het) = 4.42 (2.30-8.50), OR(hom) = 34.19 (4.48-261.00); T allele: 83.1% in cases versus 52.4% in controls).
|
18287813 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We replicated the previously reported association of three SNPs (rs1048661, rs2165241, and rs3825942) in our independent XFG population (single SNP p-values were 0.001-0.02).
|
18334928 |
2008 |
|
rs2165241
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We replicated the previously reported association of three SNPs (rs1048661, rs2165241, and rs3825942) in our independent XFG population (single SNP p-values were 0.001-0.02).
|
18334928 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Out of the two non-synonymous SNPs in exon 1 of the LOXL1 gene, rs3825942 has a significant association with XFS cases in the patients of the southern Indian population.
|
18334947 |
2008 |
|
rs1048661
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the Icelandic and Swedish populations, pseudoexfoliation syndrome (XFS) and pseudoexfoliation glaucoma (XFG) has been significantly associated with LOXL1 exon 1 polymorphisms - allele G of rs1048661 (R141L) and allele G of rs3825942 (G135D).
|
18334947 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Strong association with the three LOXL1 common sequence variants was seen in both the PEX and PEXG patient groups independent of their geographic origin (rs2165241, combined OR = 3.42, P = 1.28 x 10(-40); rs1048661, OR = 2.43, P = 2.90 x 10(-19); and rs3825942, OR = 4.87, P = 8.22 x 10(-23)).
|
18385063 |
2008 |
|
rs2165241
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Strong association with the three LOXL1 common sequence variants was seen in both the PEX and PEXG patient groups independent of their geographic origin (rs2165241, combined OR = 3.42, P = 1.28 x 10(-40); rs1048661, OR = 2.43, P = 2.90 x 10(-19); and rs3825942, OR = 4.87, P = 8.22 x 10(-23)).
|
18385063 |
2008 |
|
rs1048661
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Strong association with the three LOXL1 common sequence variants was seen in both the PEX and PEXG patient groups independent of their geographic origin (rs2165241, combined OR = 3.42, P = 1.28 x 10(-40); rs1048661, OR = 2.43, P = 2.90 x 10(-19); and rs3825942, OR = 4.87, P = 8.22 x 10(-23)).
|
18385063 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For the LOXL1 gene, individual alleles of rs1048661 (G), rs3825942 (G), and rs2165241 (T) are highly associated with XFS and XFG in American and European populations.
|
18385788 |
2008 |
|
rs2165241
|
|
|
0.800 |
GeneticVariation |
BEFREE |
For the LOXL1 gene, individual alleles of rs1048661 (G), rs3825942 (G), and rs2165241 (T) are highly associated with XFS and XFG in American and European populations.
|
18385788 |
2008 |
|
rs1048661
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For the LOXL1 gene, individual alleles of rs1048661 (G), rs3825942 (G), and rs2165241 (T) are highly associated with XFS and XFG in American and European populations.
|
18385788 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Significant association has recently been reported between pseudoexfoliation glaucoma (XFG) and two single-nucleotide polymorphisms (SNPs), rs3825942, and rs1048661, in the lysyl oxidase-like 1 gene (LOXL1).
|
18421074 |
2008 |
|
rs1048661
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Significant association has recently been reported between pseudoexfoliation glaucoma (XFG) and two single-nucleotide polymorphisms (SNPs), rs3825942, and rs1048661, in the lysyl oxidase-like 1 gene (LOXL1).
|
18421074 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Strong associations were observed for all three SNPs of LOXL1 for XFS (odds ratio [OR] = 13.56, P = 3.39 x 10(-28) for allele T of rs1048661; OR = 10.71, P = 1.49 x 10(-7) for allele G of rs3825942; and OR = 4.55, P = 5.33 x 10(-4) for allele C of rs2165241) and XFG (OR = 25.21, P = 1.44 x 10(-34) for allele T of rs1048661; OR = 11.02, P = 1.40 x 10(-7) for allele G of rs3825942; and OR = 11.89, P = 4.76 x 10(-6) for allele C of rs2165241).
|
18450598 |
2008 |
|
rs2165241
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Strong associations were observed for all three SNPs of LOXL1 for XFS (odds ratio [OR] = 13.56, P = 3.39 x 10(-28) for allele T of rs1048661; OR = 10.71, P = 1.49 x 10(-7) for allele G of rs3825942; and OR = 4.55, P = 5.33 x 10(-4) for allele C of rs2165241) and XFG (OR = 25.21, P = 1.44 x 10(-34) for allele T of rs1048661; OR = 11.02, P = 1.40 x 10(-7) for allele G of rs3825942; and OR = 11.89, P = 4.76 x 10(-6) for allele C of rs2165241).
|
18450598 |
2008 |
|
rs1048661
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Strong associations were observed for all three SNPs of LOXL1 for XFS (odds ratio [OR] = 13.56, P = 3.39 x 10(-28) for allele T of rs1048661; OR = 10.71, P = 1.49 x 10(-7) for allele G of rs3825942; and OR = 4.55, P = 5.33 x 10(-4) for allele C of rs2165241) and XFG (OR = 25.21, P = 1.44 x 10(-34) for allele T of rs1048661; OR = 11.02, P = 1.40 x 10(-7) for allele G of rs3825942; and OR = 11.89, P = 4.76 x 10(-6) for allele C of rs2165241).
|
18450598 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently, two non-synonymous polymorphisms (rs1048661 G>T and rs3825942 G>A) of lysyl oxidase-like protein 1 (LOXL1), a monoamine oxidase that catalyzes the polymerization of tropoelastin to elastin, were found to be associated with increased risk for XFS and exfoliation glaucoma (XFG).
|
18483563 |
2008 |
|
rs1048661
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, two non-synonymous polymorphisms (rs1048661 G>T and rs3825942 G>A) of lysyl oxidase-like protein 1 (LOXL1), a monoamine oxidase that catalyzes the polymerization of tropoelastin to elastin, were found to be associated with increased risk for XFS and exfoliation glaucoma (XFG).
|
18483563 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The TT genotype in the single nucleotide polymorphism (SNP) rs1048661 and the GG genotype in the SNP rs3825942 in exon 1 of LOXL1 were significantly associated with an increased risk of XFG under recessive models (chi(2) test, p=5.34 x 10(-34) and p=2.1 x 10(-8), respectively).
|
18552979 |
2008 |