|
rs4886776
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.
|
25706626 |
2015 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A significant association was found for the G allele of rs1048661 and rs3825942 in PEXG patients of Pakistani origin.
|
22605916 |
2012 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After a standard eye examination protocol we genotyped SNPs rs2165241and rs3825942 in 62 XFG or exfoliation syndrome (XFS) patients and 170 normal controls.
|
18287813 |
2008 |
|
rs2165241
|
|
|
0.800 |
GeneticVariation |
BEFREE |
After adjusting for rs3825942, rs2165241, and other factors influencing the prevalence of XFS, only rs1048661 among three SNPs remained significant (95% confidence interval=4.11-35.78, p=6.11×10(-6)).
|
22128228 |
2011 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After controlling for rs3825942 and rs2165241, the association between rs1048661 and XFS/XFG remained significant (p=3.6 x 10(-7)).
|
19936304 |
2009 |
|
rs2165241
|
|
|
0.800 |
GeneticVariation |
BEFREE |
After controlling for rs3825942 and rs2165241, the association between rs1048661 and XFS/XFG remained significant (p=3.6 x 10(-7)).
|
19936304 |
2009 |
|
rs2165241
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Allele and genotype frequencies of SNPs rs1048661, rs2165241, and rs3825942 were extracted for analysis in Reviewer Manager: (1) comparison of the allelic distributions between XFS and XFG, (2) allelic association of LOXL1 SNPs with XFS/XFG, (3) associations in homozygote, heterozygote, and dominant and recessive models, and (4) allelic association with primary open angle glaucoma (POAG).
|
20142848 |
2010 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Allelic and genotypic frequencies of three LOXL1 variants (rs1048661, rs3825942, and rs2165241) were determined for 78 consecutive Japanese patients with BRVO (11 patients with exfoliation syndrome [EX+], 67 patients without exfoliation syndrome [EX-]), and 158 patients with cataract without EX (CT) as controls.
|
22194657 |
2011 |
|
rs2165241
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Allelic and genotypic frequencies of three LOXL1 variants (rs1048661, rs3825942, and rs2165241) were determined for 78 consecutive Japanese patients with BRVO (11 patients with exfoliation syndrome [EX+], 67 patients without exfoliation syndrome [EX-]), and 158 patients with cataract without EX (CT) as controls.
|
22194657 |
2011 |
|
rs1048661
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although the functional effects of the LOXL1 SNP appear to be qualitative rather than quantitative, the amino acid substitution (R141L) caused by SNP rs1048661 is not a simple decisive factor for XFG due to the inverted allele frequency between Japanese XFG and Caucasian XFG patients.
|
18552979 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Carriers of rs3825942 AA or rs2165241 CC also had significantly less PEXS/PEXG susceptibility than did the non-carriers.
|
24603551 |
2014 |
|
rs2165241
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Carriers of rs3825942 AA or rs2165241 CC also had significantly less PEXS</span>/PEXG s</span>usceptibility than did the non-carriers.
|
24603551 |
2014 |
|
rs3825942
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.
|
17690259 |
2007 |
|
rs3825942
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.
|
17690259 |
2007 |
|
rs1048661
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Compared with the CT group, subgroup analysis showed that the CRVO EX+ group had significant differences in the allelic and genotypic frequencies of rs1048661 (p = 0.0006447 and p = 0.0001392, respectively) and had borderline differences in the allelic and genotypic frequencies of rs3825942 (p = 0.03403 and p = 0.07341, respectively), while the CRVO EX- group did not (p = 0.1324-0.6306).
|
25130441 |
2015 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Compared with the CT group, subgroup analysis showed that the CRVO EX+ group had significant differences in the allelic and genotypic frequencies of rs1048661 (p = 0.0006447 and p = 0.0001392, respectively) and had borderline differences in the allelic and genotypic frequencies of rs3825942 (p = 0.03403 and p = 0.07341, respectively), while the CRVO EX- group did not (p = 0.1324-0.6306).
|
25130441 |
2015 |
|
rs1048661
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For the LOXL1 gene, individual alleles of rs1048661 (G), rs3825942 (G), and rs2165241 (T) are highly associated with XFS and XFG in American and European populations.
|
18385788 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For the LOXL1 gene, individual alleles of rs1048661 (G), rs3825942 (G), and rs2165241 (T) are highly associated with XFS and XFG in American and European populations.
|
18385788 |
2008 |
|
rs2165241
|
|
|
0.800 |
GeneticVariation |
BEFREE |
For the LOXL1 gene, individual alleles of rs1048661 (G), rs3825942 (G), and rs2165241 (T) are highly associated with XFS and XFG in American and European populations.
|
18385788 |
2008 |
|
rs1048661
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Frequencies of the T allele of rs1048661 and the G allele of rs3825942 were significantly higher in XFS patients than in control subjects (rs1048661: 99.4% versus 55.0%; rs3825942: 99.4% versus 85.3%; p<0.0001).
|
18636115 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Frequencies of the T allele of rs1048661 and the G allele of rs3825942 were significantly higher in XFS patients than in control subjects (rs1048661: 99.4% versus 55.0%; rs3825942: 99.4% versus 85.3%; p<0.0001).
|
18636115 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genetic polymorphisms in LOXL1 (rs1048661, rs3825942, and rs2165241) have been linked to exfoliation syndrome and exfoliation glaucoma, conditions that have shown association with AD.
|
21559813 |
2011 |
|
rs2165241
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Genetic polymorphisms in LOXL1 (rs1048661, rs3825942, and rs2165241) have been linked to exfoliation syndrome and exfoliation glaucoma, conditions that have shown association with AD.
|
21559813 |
2011 |
|
rs1048661
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However rs1048661 SNP did not show an association with XFS.
|
24892565 |
2016 |
|
rs1048661
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition the G alleles of rs1048661 and rs3825942 confer an increased risk for PEXG with an odds ratio (OR) of 2.98 (95% CI 1.94-4.57) and OR 6.83 (95% CI 2.94-16.67), respectively.
|
22605916 |
2012 |