|
rs759029280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have investigated the interaction of wild-type AGT and the pathogenic G41R variant with D-cycloserine (DCS, commercialized as Seromycin), a natural product used as a second-line treatment of multidrug-resistant tuberculosis, and its synthetic enantiomer L-cycloserine (LCS).
|
31794008 |
2019 |
|
rs1182070141
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the 703 analysed strains, 12.8% were MDR; Ser531Leu and Ser315Thr being the most common recorded mutations within rpoB and katG genes associated with RIF and INH resistance respectively.
|
29486710 |
2018 |
|
rs147257994
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the 703 analysed strains, 12.8% were MDR; Ser531Leu and Ser315Thr being the most common recorded mutations within rpoB and katG genes associated with RIF and INH resistance respectively.
|
29486710 |
2018 |
|
rs371928156
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the 703 analysed strains, 12.8% were MDR; Ser531Leu and Ser315Thr being the most common recorded mutations within rpoB and katG genes associated with RIF and INH resistance respectively.
|
29486710 |
2018 |
|
rs749801396
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the 703 analysed strains, 12.8% were MDR; Ser531Leu and Ser315Thr being the most common recorded mutations within rpoB and katG genes associated with RIF and INH resistance respectively.
|
29486710 |
2018 |
|
rs1196010655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of sequencing showed that 80.2% OFX-resistant MDR-TB isolates contained <i>gyrA</i> mutation and 88.5% KAN-resistant isolates had <i>rrs</i> mutations with the most frequent mutation being A1401G.
|
28798931 |
2017 |
|
rs778662842
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of sequencing showed that 80.2% OFX-resistant MDR-TB isolates contained <i>gyrA</i> mutation and 88.5% KAN-resistant isolates had <i>rrs</i> mutations with the most frequent mutation being A1401G.
|
28798931 |
2017 |
|
rs17235409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the number of MDR-TB patients was small, our preliminary study showed that the variations of D543N and 3'UTR are significantly associated with the incidence of MDR-TB (odds ratio [OR]=5.03, 95% confidence interval [CI]=1.24-20.62; P=0.02), longer time to sputum culture conversion (OR=3.86, 95% CI=1.23-12.23; P=0.02), and cavity formation (OR=5.04, 95% CI=1.51-23.13; P=0.02).
|
17950034 |
2008 |