rs1463038513
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Prevalence of adenomatous polyps in the pathology specimens of the study participants, stratified by their APC I1307K polymorphism status, was studied in 900 consecutive cases of colorectal cancer diagnosed in northern Israel between 1998 and 2002, within the framework of a population-based, case-controlled study (MECC Study).
|
16228836 |
2005 |
rs1463038513
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The high frequency of I1307K colorectal cancer patients found in the Ashkenazi Jewish community of Ottawa and the equivalent proportion of carriers and noncarriers who developed adenomatous polyps suggest that in this community, I1307K is associated with a significant predisposition to carcinoma but not adenoma.
|
11159880 |
2001 |
rs1463038513
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The frequency of the APC I1307K mutation is elevated in Ashkenazi Jewish patients with adenomatous polyps, but not hyperplastic polyps.
|
10938175 |
2000 |
rs1463038513
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Among the genetic defects associated with CRC, the APC I1307K mutation has been detected nearly exclusively in individuals of Ashkenazi Jewish (AJ) origin, occurring in 6%-7% of the AJ general population and in 10%-28% of AJ with a either a personal or family history of CRC or adenomatous polyps.
|
11354631 |
2001 |
rs1801155
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Prevalence of adenomatous polyps in the pathology specimens of the study participants, stratified by their APC I1307K polymorphism status, was studied in 900 consecutive cases of colorectal cancer diagnosed in northern Israel between 1998 and 2002, within the framework of a population-based, case-controlled study (MECC Study).
|
16228836 |
2005 |
rs1801155
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The frequency of the APC I1307K mutation is elevated in Ashkenazi Jewish patients with adenomatous polyps, but not hyperplastic polyps.
|
10938175 |
2000 |
rs1801155
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The high frequency of I1307K colorectal cancer patients found in the Ashkenazi Jewish community of Ottawa and the equivalent proportion of carriers and noncarriers who developed adenomatous polyps suggest that in this community, I1307K is associated with a significant predisposition to carcinoma but not adenoma.
|
11159880 |
2001 |
rs1801155
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Among the genetic defects associated with CRC, the APC I1307K mutation has been detected nearly exclusively in individuals of Ashkenazi Jewish (AJ) origin, occurring in 6%-7% of the AJ general population and in 10%-28% of AJ with a either a personal or family history of CRC or adenomatous polyps.
|
11354631 |
2001 |
rs1801166
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The APC E1317Q variant in adenomatous polyps and colorectal cancers.
|
14578138 |
2003 |
rs1801166
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In all, E1317Q was identified in two of 182 patients with adenomatous polyps (1.1%) and in two of 235 controls (0.8%) (p = 0.59).
|
12537656 |
2002 |
rs34612342
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Biallelic mutations for Y165C and/or G382D were not found in any of those undergoing screening colonoscopy with 0-3 polyps (n = 400), in those APC-negative patients with <20 adenomatous polyps (n = 26), or in those with CRC who were older than 50 years (n = 328).
|
15236166 |
2004 |
rs34612342
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Using Fisher's exact test and logistic regression, we compared the frequency of the known disease-causing MYH mutations Y165C, G382D and 466delE in 137 probands (117 cases with CRC and 20 cases diagnosed on the basis of adenomatous polyps only) from families with three or more CRCs but negative for mutations in the MMR genes and in 967 healthy controls with comparable ethnic backgrounds.
|
16774938 |
2006 |
rs36053993
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Using Fisher's exact test and logistic regression, we compared the frequency of the known disease-causing MYH mutations Y165C, G382D and 466delE in 137 probands (117 cases with CRC and 20 cases diagnosed on the basis of adenomatous polyps only) from families with three or more CRCs but negative for mutations in the MMR genes and in 967 healthy controls with comparable ethnic backgrounds.
|
16774938 |
2006 |
rs36053993
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Biallelic mutations for Y165C and/or G382D were not found in any of those undergoing screening colonoscopy with 0-3 polyps (n = 400), in those APC-negative patients with <20 adenomatous polyps (n = 26), or in those with CRC who were older than 50 years (n = 328).
|
15236166 |
2004 |
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Findings from six studies of MTHFR C677T and adenomatous polyps are inconsistent.
|
14977639 |
2004 |
rs13181
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a Minnesota-based case-control study of cases with only adenomatous polyps (n = 384), only hyperplastic polyps (n = 191), or both types of polyps (n = 119) versus polyp-free controls (n = 601), we investigated the role of polymorphisms in the DNA repair genes O(6)-methylguanine methyltransferase (MGMT; p.L84F and p.I143V), XPD (p.D312N and p.K751Q), and XPG (p.D1104H).
|
16284370 |
2005 |
rs145236923
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The probability by chance that cosegregation of c.907G>A with CRC and/or adenomatous polyps occurred, in the two pedigrees combined, was 1.56%.
|
22461326 |
2012 |
rs17655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a Minnesota-based case-control study of cases with only adenomatous polyps (n = 384), only hyperplastic polyps (n = 191), or both types of polyps (n = 119) versus polyp-free controls (n = 601), we investigated the role of polymorphisms in the DNA repair genes O(6)-methylguanine methyltransferase (MGMT; p.L84F and p.I143V), XPD (p.D312N and p.K751Q), and XPG (p.D1104H).
|
16284370 |
2005 |
rs1799793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a Minnesota-based case-control study of cases with only adenomatous polyps (n = 384), only hyperplastic polyps (n = 191), or both types of polyps (n = 119) versus polyp-free controls (n = 601), we investigated the role of polymorphisms in the DNA repair genes O(6)-methylguanine methyltransferase (MGMT; p.L84F and p.I143V), XPD (p.D312N and p.K751Q), and XPG (p.D1104H).
|
16284370 |
2005 |
rs1800470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No overall association was seen between the L10P polymorphism and risk of colorectal adenomatous polyps.
|
15020570 |
2004 |
rs3219489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Q324H variant was negatively associated with the number of adenomatous polyps (OR -5.23).
|
25822476 |
2015 |
rs368939818
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings suggest that C1561T-GCPII variation may be associated with risk for adenomatous polyp, and vitamin C may modify risk by interacting with the variant gene, its expression product and/or folate substrates.
|
26028103 |
2015 |
rs587782868
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Biallelic mutations for Y165C and/or G382D were not found in any of those undergoing screening colonoscopy with 0-3 polyps (n = 400), in those APC-negative patients with <20 adenomatous polyps (n = 26), or in those with CRC who were older than 50 years (n = 328).
|
15236166 |
2004 |
rs6983267
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Serum CCAT2 and HULC were upregulated in CRC and AP patients versus controls and discriminated these groups by ROC analysis. rs6983267 GG and rs7763881 AA patients demonstrated higher serum CCAT2 and HULC compared with GT/TT and AC, respectively. rs6983267 and serum HULC predicted CRC diagnosis among non-CRC groups (AP + controls) by multivariate analysis.
|
29176650 |
2017 |
rs755001634
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings suggest that C1561T-GCPII variation may be associated with risk for adenomatous polyp, and vitamin C may modify risk by interacting with the variant gene, its expression product and/or folate substrates.
|
26028103 |
2015 |