|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The GG genotype of PNPLA3 rs738409 and the bAt (CCA) haplotype -associated with an increased risk of chronic liver disease and progression towards liver cancer- were significantly more frequent among samples exhibiting maternal and paternal Native American haplogroups (63.7 % and 64.6 %), intermediate among admixed samples (45.1 % and 44.9 %; p = 0.03) and the lowest for Non-native American ancestry (30.1 % and 29.6 %; p = 0.001 and p = 0.0008).
|
26219465 |
2015 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Variation at rs738409 was not associated with significant changes in resolution rate of hepatitis C. By contrast, M/M genotype, present at higher frequencies (22.8%) in HCC patients than in patients with chronic hepatitis C (8.5%, P = 0.004) or control individuals (9.1%, P = 0.005) was associated with a 3-fold increase of liver cancer risk.
|
24269995 |
2014 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These patients were followed-up and screened for the risk of HCC, and the influence of rs738409 on the occurrence of liver cancer was assessed using the Kaplan-Meier method, then according to the multivariate Cox model.
|
23069476 |
2013 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis.
|
22087248 |
2011 |
|
rs28934571
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The p53(R249S) mutation is the most prevalent and specific mutation associated with liver cancer development.
|
30640060 |
2019 |
|
rs28934571
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We developed liver cancer cell lines that endogenously expressed a mutant form of TP53 (R249S) or overexpressed mutant forms of STAT3 (D170Y, K348E, and Y640F) or JAK1 (S703I and L910P) and tested the abilities of pharmacologic agents to reduce activity.
|
31560893 |
2019 |
|
rs28934571
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Interestingly, the fraction of droplets positive for R249S was significantly larger in patients with liver cancer (15.3 ± 3.7%) than in controls (0.5 ± 0.3%, P = 7.1E-04).
|
29749584 |
2018 |
|
rs1682111
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR = 0.69, 95% CI: 0.52-0.93, p = 0.01; rs843720: OR = 0.73, 95% CI: 0.54-0.98, p = 0.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR = 1.42, 95% CI: 1.02-2.00, p = 0.04).The haplotype analysis detected that "ATATCGCC" decreased the risk of cirrhosis developed into liver cancer (OR = 0.69, 95% CI: 0.51-0.92, 95% CI: p = 0.013); however, "TGAGCGTC" increased the risk of cirrhosis developed into liver cancer (OR = 1.48, 95% CI: 1.04-2.10, p = 0.027).
|
31124313 |
2019 |
|
rs3787016
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs3787016 polymorphism, in polymerase II polypeptide E (POLR2E), was previously identified as being associated with the risk for prostate cancer, esophageal cancer, breast cancer, papillary thyroid carcinoma and liver cancer, suggesting that rs3787016 may server as a common genetic factor to affect individual susceptibility to cancer.
|
30846411 |
2019 |
|
rs843645
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR = 0.69, 95% CI: 0.52-0.93, p = 0.01; rs843720: OR = 0.73, 95% CI: 0.54-0.98, p = 0.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR = 1.42, 95% CI: 1.02-2.00, p = 0.04).The haplotype analysis detected that "ATATCGCC" decreased the risk of cirrhosis developed into liver cancer (OR = 0.69, 95% CI: 0.51-0.92, 95% CI: p = 0.013); however, "TGAGCGTC" increased the risk of cirrhosis developed into liver cancer (OR = 1.48, 95% CI: 1.04-2.10, p = 0.027).
|
31124313 |
2019 |
|
rs843720
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the allele model, ACYP2 rs843720 was protection against the occurrence of cirrhosis developed into liver cancer (OR = 0.76, 95% CI: 0.58-0.99, p = 0.04).
|
31124313 |
2019 |
|
rs3787016
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Although no significant association was found for rs3787016 with risk of liver or lung cancer, the further stratified analysis identified that rs3787016 contributed to liver cancer risk particularly for over than 60 years individuals who drink.
|
30291213 |
2018 |
|
rs1682111
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results confirmed that rs6713088, rs843645, rs843711 and rs843706 were significantly increased liver cancer risk, but rs1682111, rs843720 and haplotypes (ATATCGCC and CG) were significantly decreased liver cancer risk in a Han Chinese population.
|
28978066 |
2017 |
|
rs843645
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that rs6713088 (G allele: odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.07-1.52, <i>P</i> = 0.007; GG vs. CC: OR = 1.49, 95% CI: 1.02-2.1, <i>P</i> = 0.038), rs843711 (T allele: OR = 1.29, 95% CI: 1.09-1.54, <i>P</i> = 0.004; TT vs. CC: OR = 1.62, 95% CI: 1.13-2.31, <i>P</i> = 0.008), rs843706 (A allele: OR = 1.30, 95% CI: 1.09-1.55, <i>P</i> = 0.003; AA vs. CC: OR = 1.62, 95% CI: 1.13-2.31, <i>P</i> = 0.008), and rs843645 (GG vs. AG: OR = 1.40, 95% CI: 1.07-1.82, <i>P</i> = 0.014) were associated with an increased risk of liver cancer.
|
28978066 |
2017 |
|
rs843720
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results confirmed that rs6713088, rs843645, rs843711 and rs843706 were significantly increased liver cancer risk, but rs1682111, rs843720 and haplotypes (ATATCGCC and CG) were significantly decreased liver cancer risk in a Han Chinese population.
|
28978066 |
2017 |
|
rs1447295
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In a dominant model, among those with a family history of cancer, rs1447295 was positively associated with liver cancer (OR(adj) 2.80; 95% CI 1.15-6.80).
|
24030569 |
2014 |
|
rs1801133
|
|
|
0.020 |
GeneticVariation |
BEFREE |
After shrinkage and adjusting for potential confounding factors, we found positive associations between MTHFR rs1801133 and stomach cancer (any T versus C/C, SB odds-ratio [SBOR]: 1.79, 95% posterior limits: 1.18, 2.71) and liver cancer (SBOR: 1.51, 95% posterior limits: 0.98, 2.32).
|
25337902 |
2014 |
|
rs1801133
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Therefore, MTHFR Ala222Val polymorphism is significantly associated with risk of hepatitis infection but not liver cancer</span>.
|
24155211 |
2014 |
|
rs4444903
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the current meta-analysis suggests that the G variant of the rs4444903 polymorphism may increase</span> the risk of liver cancer.
|
25299191 |
2014 |
|
rs6983267
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Heterogeneity was observed (P(heterogeneity) = 0.029) with rs6983267 and liver cancer, with positive association in the dominant model among those with a family history of cancer and positive association in the recessive model among those without a family history of cancer.
|
24030569 |
2014 |
|
rs4444903
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The epidermal growth factor (EGF) rs4444903 A>G polymorphism has been associated with the development of liver cancer, which commonly complicates cirrhosis of viral origin; however, whether this polymorphism might be associated with fibrosis progression in chronic viral hepatitis is unknown.
|
22122913 |
2012 |
|
rs1447295
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers.
|
18990762 |
2008 |
|
rs6983267
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also observed a suggestive association between rs6983267 and liver cancer (ORadj, 1.51; 95% CI, 0.99-2.31).
|
18990762 |
2008 |
|
rs367597251
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Ras-carrying G12V and Y40C site mutation was transfected into liver cancer cell lines SNU-475 and SK-Hep-1.
|
31642074 |
2020 |
|
rs1046282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |