|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, considering that these parameters are determinant for protein interactions and, consequently, protein function; the alterations observed throughout the MD analyses may be related to the functional impairment of BDNF upon V66M mutation, as well as its involvement in psychiatric disorders.
|
30998730 |
2019 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In humans and knock-in mice with a loss of function BDNF SNP (Val66Met), the functionality of this circuit was altered, resulting in social behavioral changes in human and mice.
|
30992540 |
2019 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In humans and knock-in mice with a loss of function BDNF SNP (Val66Met), the functionality of this circuit was altered, resulting in social behavioral changes in human and mice.
|
30992540 |
2019 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, considering that these parameters are determinant for protein interactions and, consequently, protein function; the alterations observed throughout the MD analyses may be related to the functional impairment of BDNF upon V66M mutation, as well as its involvement in psychiatric disorders.
|
30998730 |
2019 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between COMT Val158Met and psychiatric disorders: A comprehensive meta-analysis.
|
28608575 |
2018 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study provides evidence that Val66Met is associated with cortical maturation in children and adolescents with and without psychiatric disorders.
|
29288952 |
2018 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study provides evidence that Val66Met is associated with cortical maturation in children and adolescents with and without psychiatric disorders.
|
29288952 |
2018 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further research with larger samples is needed to explore the interactions of the COMT gene rs4680 polymorphism and sex and psychiatric disorders on suicide attempts.
|
27203226 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) is associated with psychiatric disorders and regional gray matter volume (rGMV) in adults.
|
26830347 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Gene-by-environment studies investigating the impact of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the Brain Derived Neurotrophic Factor (BDNF) Val66Met polymorphisms by life events on mental health and behaviour problems have been inconclusive.
|
27267363 |
2016 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Gene-by-environment studies investigating the impact of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the Brain Derived Neurotrophic Factor (BDNF) Val66Met polymorphisms by life events on mental health and behaviour problems have been inconclusive.
|
27267363 |
2016 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) is associated with psychiatric disorders and regional gray matter volume (rGMV) in adults.
|
26830347 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Variants in BDNF, in particular the functional Val66Met polymorphism (rs6265), have been found to be associated with a number of psychiatric disorders, cognitive function, and obesity.
|
24708359 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Val66Met (also known as rs6265 or G196A), the only known functional polymorphism of the BDNF gene, has been widely studied and considered to be associated with risk of some psychiatric disorders such as bipolar disorder and schizophrenia.
|
26503495 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here we comprehensively review the role and relevance of the Val66Met polymorphism in psychiatric disorders, with emphasis on suicidal behavior and anxiety, eating, mood and psychotic disorders.
|
25824305 |
2015 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Val66Met (also known as rs6265 or G196A), the only known functional polymorphism of the BDNF gene, has been widely studied and considered to be associated with risk of some psychiatric disorders such as bipolar disorder and schizophrenia.
|
26503495 |
2015 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Variants in BDNF, in particular the functional Val66Met polymorphism (rs6265), have been found to be associated with a number of psychiatric disorders, cognitive function, and obesity.
|
24708359 |
2015 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here we comprehensively review the role and relevance of the Val66Met polymorphism in psychiatric disorders, with emphasis on suicidal behavior and anxiety, eating, mood and psychotic disorders.
|
25824305 |
2015 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional polymorphism COMT Val158Met has been associated with psychiatric disorders including suicidal behavior.
|
24389396 |
2014 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatric disorders.
|
24708432 |
2014 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis.
|
23799032 |
2013 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies show that the Val(66)Met BDNF polymorphism correlates with various psychiatric disorders, including anxiety, but there are several differences between experimental and clinical studies.
|
24051499 |
2013 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies show that the Val(66)Met BDNF polymorphism correlates with various psychiatric disorders, including anxiety, but there are several differences between experimental and clinical studies.
|
24051499 |
2013 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The catechol-O-methyltransferase (COMT) Val158Met polymorphism moderates the effect of antenatal stress on childhood behavioural problems: longitudinal evidence across multiple ages.
|
22070166 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One of its most widely studied variations comprises a common single nucleotide polymorphism (SNP), a valine-to-methionine substitution at codon 158 (COMT Val158Met), which has been associated with various cognitive phenotypes, psychiatric disorders and changes in brain activation and structure.
|
22138198 |
2012 |