Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11142387
rs11142387 		0.010 GeneticVariation BEFREE In particular, carrying the A allele of rs11142387 near KLF9 was found to be associated with psychiatric disease and poor memory performance, which warrants further investigations. 27923415

2017
dbSNP: rs3851179
rs3851179 		0.010 GeneticVariation BEFREE There was an effect of the APOE-PICALM (rs3851179) interactions on reduced CMRgl in regions of vDMN (P < .001), and on memory deficits (F<sub>3,93</sub> =5.568, P = .020). 29883038

2019
dbSNP: rs744373
rs744373 		0.010 GeneticVariation BEFREE Together, our findings suggest that the BIN1 rs744373 SNP is associated with increased tau but not beta-amyloid pathology, suggesting that alterations in BIN1 may contribute to memory deficits via increased tau pathology. 30992433

2019
dbSNP: rs63750264
rs63750264
APP
0.020 GeneticVariation BEFREE We previously showed that mice over-expressing a human mutated form of APP (APP(V717F)) display age-dependent recognition memory deficits associated with the progression of amyloid deposition. 10718322

2000
dbSNP: rs63750264
rs63750264
APP
0.020 GeneticVariation BEFREE The Tg-APP (Sw, V717F)/B6 mice at 11-14 months displayed decreased motor coordination, learning and memory deficits, and severely increased anxiety. 15114629

2004
dbSNP: rs572842823
rs572842823
APP
0.010 GeneticVariation BEFREE A recently described mouse line, Tg(HuAPP695.K670N/M671L)2576, expressing human amyloid precursor protein with a familial AD gene mutation, age-related amyloid deposits, and memory deficits, was found to develop a significant microglial response using Griffonia simplicifolia lectin or phosphotyrosine probe to identify microglia Both Griffonia simplicifolia lectin and phosphotyrosine staining showed increased numbers of intensely labeled, often enlarged microglia clustered in and around plaques, consistent with microglial activation related to beta-amyloid formation. 9422548

1998
dbSNP: rs781049584
rs781049584
APP
0.010 GeneticVariation BEFREE Mice carrying mutated human APPswe and PS1 (A246E) transgenes (A/P mice) show age-dependent memory impairment in hippocampus-dependent tasks. 15006688

2004
dbSNP: rs12273363
rs12273363
BDNF
0.010 GeneticVariation BEFREE Specifically, we examined nine BDNF single-nucleotide polymorphisms (SNPs; rs908867, rs11030094, rs6265, rs10501087, rs1157659, rs1491850, rs11030107, rs7127507 and rs12273363) previously associated with brain atrophy or memory deficits in mTBI. 28755387

2018
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE A previously reported valine to methionine substitution at amino-acid position 66 (BDNF Val66Met) seems to account for memory disturbance and hippocampal dysfunction. 17392738

2007
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE A Val(66)Met single-nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene impairs activity-dependent BDNF release in cultured hippocampal neurons and predicts impaired memory and exaggerated basal hippocampal activity in healthy humans. 23319002

2013
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. 27521573

2016
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. 27521573

2016
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE A previously reported valine to methionine substitution at amino-acid position 66 (BDNF Val66Met) seems to account for memory disturbance and hippocampal dysfunction. 17392738

2007
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE A Val(66)Met single-nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene impairs activity-dependent BDNF release in cultured hippocampal neurons and predicts impaired memory and exaggerated basal hippocampal activity in healthy humans. 23319002

2013
dbSNP: rs7127507
rs7127507
BDNF ; BDNF-AS
0.010 GeneticVariation BEFREE Specifically, we examined nine BDNF single-nucleotide polymorphisms (SNPs; rs908867, rs11030094, rs6265, rs10501087, rs1157659, rs1491850, rs11030107, rs7127507 and rs12273363) previously associated with brain atrophy or memory deficits in mTBI. 28755387

2018
dbSNP: rs1424266770
rs1424266770
CASP3
0.010 GeneticVariation BEFREE H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment. 24439478

2014
dbSNP: rs1554317002
rs1554317002
CDK13 ; LOC112267983
T 0.700 GeneticVariation CLINVAR

dbSNP: rs281865071
rs281865071
CHRNB2
0.020 GeneticVariation BEFREE Autosomal dominant nocturnal frontal lobe epilepsy and mild memory impairment associated with CHRNB2 mutation I312M in the neuronal nicotinic acetylcholine receptor. 18534914

2008
dbSNP: rs281865071
rs281865071
CHRNB2
0.020 GeneticVariation BEFREE The CHRNB2 mutation I312M is associated with epilepsy and distinct memory deficits. 15964197

2005
dbSNP: rs80356702
rs80356702
CLCN1
A 0.700 GeneticVariation CLINVAR

dbSNP: rs11136000
rs11136000
CLU
0.010 GeneticVariation BEFREE Interestingly, the complex communications between resting-state networks were enhanced in aMCI subjects with the CLU rs11136000 CC genotype and were modulated by the degree of memory impairment, suggesting a reconstructed balance of the resting-state networks in these individuals with an elevated risk of AD. 26899953

2016
dbSNP: rs4680
rs4680
COMT ; MIR4761
0.020 GeneticVariation BEFREE The COMT val(158)met polymorphism was associated with abstinence-related working memory deficits in two independent samples of smokers. 23828159

2013
dbSNP: rs4680
rs4680
COMT ; MIR4761
0.020 GeneticVariation BEFREE We propose that an interaction of the DRD2 C957T and COMT Val158Met may be involved in the generation of some working memory deficits in schizophrenia. 17113268

2007
dbSNP: rs1556424691
rs1556424691
CYTB ; ND6 ; TRNT
G 0.700 CausalMutation CLINVAR Mitochondrial disorder associated with newborn cardiopulmonary arrest. 8511015

1993
dbSNP: rs1556424691
rs1556424691
CYTB ; ND6 ; TRNT
G 0.700 CausalMutation CLINVAR New mitochondrial DNA mutations in tRNA associated with three severe encephalopamyopathic phenotypes: neonatal, infantile, and childhood onset. 22638997

2012