|
rs10433937
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that SERPINA1 Pi*S variant conferred an increased risk of developing liver fibrosis, while SERPINA1 Pi*Z and HSD17B13 rs10433937 were not associated with liver fibrosis or cirrhosis of different aetiology.
|
31517326 |
2019 |
|
rs1544410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Old age (p = 5.05 × 10<sup>-8</sup>), high body mass index (p = 2.13 × 10<sup>-2</sup>), low total-cholesterol (p = 1.46 × 10<sup>-4</sup>), low serum vitamin D level (p = 7.34 × 10<sup>-3</sup>), and VDR rs1544410 genotype CC (p = 9.15 × 10<sup>-3</sup>) were independent factors associated with advanced liver fibrosis.
|
30683615 |
2019 |
|
rs2228570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The <i>FokI</i> rs2228570 TT/TC genotypes (OR = 1.63, 95% CI [1.06-2.51], <i>p</i> = 0.03) and age ≥55 years (OR = 2.25; 95% CI [1.54-3.32], <i>p</i> < 0.001) were independently associated with advanced liver fibrosis, assessed based on FIB-4 score >3.25.
|
31565578 |
2019 |
|
rs6920220
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to analyze the associations between genetic variants upstream of TNFAIP3 (rs675520, rs9376293 and rs6920220) and liver fibrosis severity and inflammation in HIV/HCV-coinfected patients.
|
30336268 |
2019 |
|
rs72613567
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HSD17B13 rs10433937 (in high linkage disequilibrium with rs72613567; r 2 =0.96) also showed no overall association with liver disease, but the GG- genotype was associated with reduced risk of liver fibrosis (aOR 0.37, p=0.03).
|
31517326 |
2019 |
|
rs1143627
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The AA genotype at rs16944 and the CC genotype at rs1143627 in the gene encoding IL-1β were associated with higher serum IL-1β levels and liver fibrosis.
|
29390144 |
2018 |
|
rs16944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The AA genotype at rs16944 and the CC genotype at rs1143627 in the gene encoding IL-1β were associated with higher serum IL-1β levels and liver fibrosis.
|
29390144 |
2018 |
|
rs4588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the rs7041 and rs4588 GC polymorphisms are strong predictors of vitamin D levels, they do not play a direct role in liver fibrosis.
|
28809744 |
2018 |
|
rs6897932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The IL7RA rs6897932 polymorphism seems to be related to increased risk of liver fibrosis progression in HCV-infected patients.
|
29742149 |
2018 |
|
rs7041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the rs7041 and rs4588 GC polymorphisms are strong predictors of vitamin D levels, they do not play a direct role in liver fibrosis.
|
28809744 |
2018 |
|
rs1127354
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate analysis showed that IPTA rs1127354 non-genotype CC, HCV genotype, a baseline HCV RNA level <4 × 10 IU/mL, IL-28B rs12979860 genotype CC, and low liver fibrosis were independent predictors for SVR during the combination therapy.IPTA rs1127354 variants and related ITPase were not only related with ribavirin-induced hemolytic anemia but also directly affected the SVR to PEG-IFN plus ribavirin combination therapy in Chinese HCV-infected patients.
|
28723780 |
2017 |
|
rs11558492
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings indicate that GNPAT rs11558492 is not a major modifier of iron status and is not associated with liver fibrosis in HFE-HH patients.
|
28425416 |
2017 |
|
rs12785878
|
|
|
0.010 |
GeneticVariation |
BEFREE |
By multivariate analysis, liver fibrosis stage 0-1 (OR = 5.00; 95% CI, 2.02-12.37; P < 0.001), and DHCR7 rs12785878 GT/TT allele (OR = 2.69; 95% CI, 1.03-7.05; P = 0.04) were independent pre-treatment predictors of SVR following PEG-IFN-based therapy in HCV genotype 1 patients.
|
28415985 |
2017 |
|
rs16851720
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study showed that PNPLA3 rs738409 and RNF7 rs16851720 confer an increased risk of developing liver fibrosis and cirrhosis in this Eastern European population, while the MERTK and PCSK7 SNPs are not associated with these conditions.
|
28338112 |
2017 |
|
rs17047200
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate analysis showed rs17047200 AT/TT to be an independent risk factor for HCC (hazard ratio, 1.78; P = .008), along with male sex, older age, lower level of albumin, advanced stage of hepatic fibrosis, presence of diabetes, and higher post-treatment level of α-fetoprotein.
|
28163062 |
2017 |
|
rs2596542
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Serum level and single nucleotide polymorphism at rs2596542 of MICA were tested for the association with liver fibrosis in 319 biopsy proven chronic hepatitis C patients.
|
28427234 |
2017 |
|
rs3480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Fibronectin Type III Domain-Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.
|
28472477 |
2017 |
|
rs1001179
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the association of genetic polymorphisms of CAT C-262T (rs1001179) and GPX1 Pro198Leu (rs1050450) with different stages of liver fibrosis and development of hepatocellular carcinoma (HCC).
|
26990426 |
2016 |
|
rs1050450
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the association of genetic polymorphisms of CAT C-262T (rs1001179) and GPX1 Pro198Leu (rs1050450) with different stages of liver fibrosis and development of hepatocellular carcinoma (HCC).
|
26990426 |
2016 |
|
rs1060500764
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overexpression of HNRNPA1 (or its T51A mutant) in HSCs of mice inhibited liver fibrosis.
|
26435271 |
2016 |
|
rs1063303
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with TRIM22 rs1063303 GG genotype had higher proportion of significant liver fibrosis than patients with rs1063303 CC/CG genotypes (p = 0.021), and they had increased odds of having significant hepatic fibrosis (aOR = 2.19; p = 0.034).
|
27590274 |
2016 |
|
rs10833
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The presence of IL15 rs10833 AA genotype in HIV-/HCV-co-infected patients was associated with advanced liver fibrosis, inflammation-related biomarkers and increased rates of SVR to pegIFN-alpha/RBV therapy.
|
26836972 |
2016 |
|
rs781521972
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overexpression of HNRNPA1 (or its T51A mutant) in HSCs of mice inhibited liver fibrosis.
|
26435271 |
2016 |
|
rs900837802
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overexpression of HNRNPA1 (or its T51A mutant) in HSCs of mice inhibited liver fibrosis.
|
26435271 |
2016 |
|
rs10336
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The homozygosity for the minor alleles CXCL9 rs10336 (T), CXCL10 rs3921 (G), and CXCL11 rs4619915 (A) is associated with the higher likelihood of significant liver fibrosis in HIV-infected patients coinfected with HCV-GT1.
|
25559603 |
2015 |