|
rs8099917
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Univariate analysis revealed that, compared to patients without advanced liver fibrosis, patients with advanced liver fibrosis (Metavir fibrosis score 3-4) had an older age, a lower platelet count, a higher α-fetoprotein level, a higher alanine aminotransferase level, a higher incidence of diabetes, and a higher frequency of rs8099917 non-TT genotype carriage.Logistic regression analysis revealed that factors significantly associated with advanced liver fibrosis included age (odds ratio [OR]/95% confidence interval [CI]: 1.023/1.009-1.037, P = .001), diabetes (OR/CI: 1.736/1.187-2.539, P = .004), α-fetoprotein (OR/CI: 1.007/1.002-1.012, P = .009), platelet count (OR/CI: 0.991/0.988-0.993, P < .001), and carriage of the rs8099917 non-TT genotype (OR/CI: 0.585/0.400-0.856, P = .006).
|
29517696 |
2018 |
|
rs8099917
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Multivariate analysis (odds ratio; 95% confidence interval; P value) indicated that the rs8099917 TT genotype was a strong predictor of treatment success (5.83; 1.26-26.92; P = 0.021), independent of baseline plasma HCV-RNA load less than 500 000 IU/ml (4.85; 1.18-19.95; P = 0.025) and absence of advanced liver fibrosis (5.24; 1.20-22.91; P = 0.025).
|
21048934 |
2010 |
|
rs8099917
|
|
|
0.070 |
GeneticVariation |
BEFREE |
No association between PNPLA3 rs738409/IL28B rs8099917 genotypes and hepatic steatosis or liver fibrosis was observed.
|
24349054 |
2013 |
|
rs8099917
|
|
|
0.070 |
GeneticVariation |
BEFREE |
This study aims to assess the impact of IL28B rs8099917 polymorphism on CHC genotype 4 (G4) susceptibility and liver fibrosis progression individually; and in combination with PNPLA3 rs738409.<b>Patients and methods:</b> IL28B rs8099917 and PNPLA3 rs738409 were genotyped in 150 Egyptian CHC patients and 175 healthy controls using real-time PCR.<b>Results:</b> IL28B rs8099917 genotype distribution significantly differs in healthy individuals versus CHC patients (<i>p</i> = .018); and in low versus advanced fibrosis IL28B (<i>p</i> = .013).
|
31793339 |
2019 |
|
rs8099917
|
|
|
0.070 |
GeneticVariation |
BEFREE |
During observation, 131 patients with chronic infection underwent a liver biopsy; age (OR 1.058; P = 0.01) G/T or G/G genotypes of rs8099917 polymorphism (OR 3.962; P = 0.001), and C/T or T/T genotypes of rs12979860 polymorphism (OR 3.494; P = 0.005) were associated with severe liver fibrosis, independent of liver iron concentration.
|
22180419 |
2012 |
|
rs8099917
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Multivariate analysis revealed that a baseline HCV viral load <400,000 IU/mL was the strongest predictor of RVR [odds ratio (OR) = 4.27, 95% confidence interval (CI) = 2.31-7.87, P < 0.001], and this was followed by advanced liver fibrosis (OR = 0.28, 95% CI = 0.15-0.53, P < 0.001), the carriage of the rs8099917 TT genotype (OR = 3.10, 95% CI = 1.34-7.21, P = 0.008), and the pretreatment level of aspartate aminotransferase (OR = 0.996, 95% CI = 0.99-1.00, P = 0.04).
|
21254157 |
2011 |
|
rs8099917
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The present study was designed to assess the contribution of these SNPs to disease progression in patients with chronic hepatitis C. The study enrolled 220 Japanese patients with chronic hepatitis C. Three SNPs, -1195 COX-2, PNPLA3 and IL28B (rs8099917), were genotyped in order to analyze their association with hepatic fibrosis and inflammation.
|
22863264 |
2012 |
|
rs12980275
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variables significantly associated with SVR in a multivariate analysis were HCV-genotype (GT) 3 {adjusted odds ratio [aOR] = 7.66 [95% of confidence interval (95% CI): 3.96 to 14.81] P < 0.001}, HCV-viremia <500,000 IU/mL [aOR = 2.20 (95% CI: 1.16 to 4.15] P = 0.015), no/mild liver fibrosis (F < 2) [aOR = 1.92 (95% CI: 1.08 to 3.42) P = 0.026], IL28B rs12980275 AA genotype [aOR = 2.70 (95% CI: 1.54 to 4.71) P < 0.001], and PPARγ2 rs1801282 CG/GG genotype [aOR = 2.93 (95% CI: 1.27 to 6.72) P = 0.011].
|
25072612 |
2014 |
|
rs6920220
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to analyze the associations between genetic variants upstream of TNFAIP3 (rs675520, rs9376293 and rs6920220) and liver fibrosis severity and inflammation in HIV/HCV-coinfected patients.
|
30336268 |
2019 |
|
rs9402373
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that the single nucleotide polymorphism (SNP) rs9402373 that lies close to CTGF is associated with severe HF (P = 2 x 10(-6); odds ratio [OR] = 2.01; confidence interval of OR [CI] = 1.51-2.7) in two Chinese samples, in Sudanese, and in Brazilians infected with either Schistosoma japonicum or S. mansoni.
|
19822645 |
2009 |
|
rs12075
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Specifically, patients with the <i>DARC</i> rs12075 AG/GG genotype had a lower risk of liver fibrosis progression and development of cirrhosis.
|
30970632 |
2019 |
|
rs12075
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We here tested the hypothesis that this genetic variant (rs12075 A/G) is a risk factor for liver fibrosis in HCV infection.
|
21156192 |
2011 |
|
rs3921
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The homozygosity for the minor alleles CXCL9 rs10336 (T), CXCL10 rs3921 (G), and CXCL11 rs4619915 (A) is associated with the higher likelihood of significant liver fibrosis in HIV-infected patients coinfected with HCV-GT1.
|
25559603 |
2015 |
|
rs4619915
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The homozygosity for the minor alleles CXCL9 rs10336 (T), CXCL10 rs3921 (G), and CXCL11 rs4619915 (A) is associated with the higher likelihood of significant liver fibrosis in HIV-infected patients coinfected with HCV-GT1.
|
25559603 |
2015 |
|
rs1001179
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the association of genetic polymorphisms of CAT C-262T (rs1001179) and GPX1 Pro198Leu (rs1050450) with different stages of liver fibrosis and development of hepatocellular carcinoma (HCC).
|
26990426 |
2016 |
|
rs10336
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The homozygosity for the minor alleles CXCL9 rs10336 (T), CXCL10 rs3921 (G), and CXCL11 rs4619915 (A) is associated with the higher likelihood of significant liver fibrosis in HIV-infected patients coinfected with HCV-GT1.
|
25559603 |
2015 |
|
rs4444903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The EGF rs4444903 A>G polymorphism may facilitate liver fibrosis progression in Caucasian patients with chronic hepatitis C, especially in younger patients.
|
22122913 |
2012 |
|
rs900837802
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overexpression of HNRNPA1 (or its T51A mutant) in HSCs of mice inhibited liver fibrosis.
|
26435271 |
2016 |
|
rs3480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Fibronectin Type III Domain-Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.
|
28472477 |
2017 |
|
rs4588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the rs7041 and rs4588 GC polymorphisms are strong predictors of vitamin D levels, they do not play a direct role in liver fibrosis.
|
28809744 |
2018 |
|
rs7041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the rs7041 and rs4588 GC polymorphisms are strong predictors of vitamin D levels, they do not play a direct role in liver fibrosis.
|
28809744 |
2018 |
|
rs780094
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In patients with NAFLD, GCKR rs780094 C>T is associated with the severity of liver fibrosis and with higher serum triglyceride levels.
|
24498332 |
2014 |
|
rs11558492
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings indicate that GNPAT rs11558492 is not a major modifier of iron status and is not associated with liver fibrosis in HFE-HH patients.
|
28425416 |
2017 |
|
rs1050450
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the association of genetic polymorphisms of CAT C-262T (rs1001179) and GPX1 Pro198Leu (rs1050450) with different stages of liver fibrosis and development of hepatocellular carcinoma (HCC).
|
26990426 |
2016 |
|
rs7080536
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (G534E, Marburg I, MI-SNP) in the gene encoding FSAP (HABP2) leads to lower enzymatic activity and is associated with enhanced liver fibrosis in humans.
|
22989567 |
2013 |