|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the combination of high red meat consumption, low menstrual blood loss and the HFE C282Y mutation may protect from iron deficiency in women of childbearing age.
|
24663082 |
2014 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, high-level expression of a liver-specific Hfe transgene carrying the mouse equivalent of the common HFE C282Y human disease-causing mutation (murine C294Y) did not cause iron deficiency.
|
20837779 |
2010 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Iron deficiency and frequency of HFE C282Y gene mutation in Brazilian blood donors.
|
19747287 |
2009 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Iron absorption is decreased in some patients with hemochromatosis and HFE C282Y homozygosity after bariatric surgery, but their risk of developing iron deficiency may be diminished.
|
15603661 |
2005 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Prevalence of non-anaemic iron deficiency was significantly lower among female carriers of the C282Y mutation compared with HFE wild types.
|
12614226 |
2003 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
DMT-1 expression in C282Y homozygote subjects is consistent with the hypothesis of a "paradoxical" duodenal iron deficiency in hereditary hemochromatosis.
|
12547214 |
2003 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C282Y and H63D +/- may protect against iron deficiency.
|
14642607 |
2003 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our observations suggest that the protective effect of C282Y heterozygosity against iron deficiency may be less significant than other environmental (e.g., iron-rich diet) or genetic factors.
|
11358395 |
2001 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Homozygosity for C282Y and conditions of iron deficiency result in a downregulation of Hfe.
|
10772870 |
2000 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the younger age group, C282Y wild-type women did not have significantly increased serum iron, transferrin saturation, or hemoglobin values, and were not protected from developing iron deficiency, compared with women of the same age with the wild-type genotype.
|
10657371 |
2000 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data provide evidence for a protective role of the C282Y mutation in the HFE gene against iron deficiency in young women and suggest that a more efficient utilization of nutritional iron may have contributed to the high prevalence of the mutation in Caucasian populations.
|
9836708 |
1998 |
|
rs1799945
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our findings suggest that selective pressure by mild iron deficiency contributes to the high frequencies of the p.H63D variant.
|
30827762 |
2019 |
|
rs1799945
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Homozygocity for C in rs1799945 was associated with iron deficiency in women.
|
26597663 |
2016 |
|
rs1799945
|
|
|
0.030 |
GeneticVariation |
BEFREE |
C282Y and H63D +/- may protect against iron deficiency.
|
14642607 |
2003 |
|
rs1303530299
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the combination of high red meat consumption, low menstrual blood loss and the HFE C282Y mutation may protect from iron deficiency in women of childbearing age.
|
24663082 |
2014 |
|
rs1303530299
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This SNP along with the C282Y mutation explained significant differences in the distribution of individuals in three iron-related clinical phenotypes (normal, iron deficient and iron deficiency anaemic).
|
23324578 |
2013 |
|
rs1143627
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ABO (rs505922) and IL1B (rs1143627) may affect H pylori infection susceptibility, and IL1B (rs1143627) may also influence ID risk in infected children.
|
28727656 |
2018 |
|
rs505922
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ABO (rs505922) and IL1B (rs1143627) may affect H pylori infection susceptibility, and IL1B (rs1143627) may also influence ID risk in infected children.
|
28727656 |
2018 |
|
rs2201841
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2201841 showed to be a risk factor for the development of iron deficiency (<i>P</i> = 0.0388, OR = 6.1837).
|
28210080 |
2017 |
|
rs104894347
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We previously demonstrated that the combination of iron deficiency and a knock-in R176Q FGF23 mutation in mature mice induced FGF23 expression and hypophosphatemia that paralleled the late-onset ADHR phenotype.
|
23873717 |
2014 |
|
rs28940298
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Studies including 16 additional VHL(R200W) homozygotes with low ferritin indicated that iron deficiency enhanced the induction effect of VHL(R200W) for 50 genes including hemoglobin synthesis loci but suppressed the effect for 107 genes enriched for HIF-2 targets.
|
23993337 |
2014 |
|
rs855791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In 545 children below 5 years of age from rural southern Rwanda, we assessed the role of iron deficiency (ID) and of the TMPRSS6 736(V) (rs855791) allele, known to reduce iron status and haemoglobin (Hb) levels, in anaemia and Hb concentrations.
|
24175968 |
2014 |
|
rs11549465
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the HIF-1α(Pro-582-Ser) polymorphism protected regular blood donors from developing iron deficiency and anaemia and predicted uninterrupted donation activity.
|
24120591 |
2013 |
|
rs3811647
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants rs3811647 in TF and rs7385804 in TFR2 were associated with reduced SI, serum transferrin and transferrin saturation levels; however, these variants were not associated with iron deficiency or anemia risk.
|
22323359 |
2012 |
|
rs7385804
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants rs3811647 in TF and rs7385804 in TFR2 were associated with reduced SI, serum transferrin and transferrin saturation levels; however, these variants were not associated with iron deficiency or anemia risk.
|
22323359 |
2012 |