| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.030 | GeneticVariation | BEFREE | Results revealed significant differences in rs670 and rs2292318 allele frequencies between cases and controls (P<0.025). rs670 G allele carriers were more likely to develop dyslipidemia than A allele carriers (OR = 1.315, OR 95% CI: 1.067-2.620; P = 0.010). rs2292318 T allele carriers were more likely to develop dyslipidemia than A allele carriers (OR = 1.264, OR 95% CI: 1.037-1.541; P = 0.020). | 29758034 | 2018 |
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|
0.030 | GeneticVariation | BEFREE | The frequencies of the A allele for rs670 were found to be 14.3% (dyslipidemia group) and 12.7% (control group). | 27173266 | 2016 |
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|
0.030 | GeneticVariation | BEFREE | ApoB rs512535 and ApoA1 rs670 major G allele homozygotes had increased MetS risk (OR 1.65 [CI 1.24, 2.20], P = 0.0006; OR 1.42 [CI 1.08, 1.87], P = 0.013), which may be, partly, explained by their increased abdominal obesity and impaired insulin sensitivity (P<0.05) but not dyslipidemia. | 21122859 | 2011 |
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|
0.010 | GeneticVariation | BEFREE | Furthermore, the association of <i>APOA1</i> rs5072 in this gene cluster with dyslipidemia differed between genders; thus, additional studies are needed to confirm this conclusion, and the mechanisms underlying these results warrant further exploration. | 30631647 | 2019 |
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|
0.010 | GeneticVariation | BEFREE | Most importantly, the variant rs632153 is involved in elevating TC, LDLC, TG and VLDLs and probably playing a crucial role in the manifestation of dyslipidemia. | 28610615 | 2017 |
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|
0.010 | GeneticVariation | BEFREE | These findings indicate that the polymorphisms in the APOA1 gene (rs670, rs5069, and rs2070665) are not associated with dyslipidemia in the Kazakh population assessed in this study. | 27173266 | 2016 |
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|
0.010 | GeneticVariation | BEFREE | These findings indicate that the polymorphisms in the APOA1 gene (rs670, rs5069, and rs2070665) are not associated with dyslipidemia in the Kazakh population assessed in this study. | 27173266 | 2016 |